A Multisite Randomized Trial of BattleViro: A Mobile Gaming App to Improve ART Adherence for Youth

BattleViro 的多站点随机试验：一款提高青少年 ART 依从性的移动游戏应用程序

基本信息

批准号：
10175048
负责人：
James Benjamin Brock
金额：
$ 69.5万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-24 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10175048
关键词：
AIDS/HIV problem Accounting Achievement Adherence Administrator Adolescent and Young Adult Analysis of Covariance Behavioral Biological Boston Caring Cellular Phone Centers for Disease Control and Prevention (U.S.)Chronic Clinic Collection Control Groups Data Development Devices Disease Elements HIV HIV Infections Health Benefit Immersion Individual Information Systems Intervention Interview Knowledge Life Measures Mediator of activation protein Medical Mississippi Modeling Motivation Nature New England Participant Patients Pharmaceutical Preparations Play RNA Research Risk Sample Size Self Efficacy Social support Subgroup Technology Testing Text Text Messaging Time Translating United States Viral Load result Youth adherence rate age group body system clinical research site comparative efficacy comparison intervention efficacy testing electronic data experience fighting follow-up hedonic improved mobile application novel organizational structure portability randomized controlled study randomized trial skills smartphone Application social engagement treatment adherence virtual reality game

项目摘要

Despite need for consistent adherence to medical care, youth living with HIV (YLWH) have low rates of adherence and retention in care, and are at great risk for being lost to follow-up.(5,16-18) There is a great need for adherence interventions that are novel and appealing for YLWH.(7,8,14) We developed, and preliminarily examined, a multi-level technology that integrates a 7-day smart medication device (Wisepill) WITH an immersive and appealing smartphone app/game that is attractive and engaging for YLWH.(82,83) During gameplay, YLWH fight HIV in colorful and immersive organ systems, and receive adherence related text messages with game graphics. Wisepill openings guide game-related text messages and can result in bonus points in the app/game. We tested the Multilevel Gaming Intervention in a developmental trial. The impact of the intervention was greatest among those who had newly begun ART. In participants who had newly begun ART, the intervention decreased viral load and improved ART adherence. Those newly starting ART in the intervention, compared to those newly starting ART in the control, experienced a 0.96 log viral load greater decrease and evidenced a large effect size for improved adherence as measured by Wisepill (d=1.18, 71% vs. 48% adherence at post-test). These interactions between intervention and newly starting ART were significant in ANCOVAs, accounting for baseline values (viral load: F=4.33, p=0.04, adherence: F=3.20, p=0.05). For this next proposed stage of research, we will further test the Multilevel Gaming Intervention with YLWH who are newly starting ART at clinical sites in New England and in Mississippi. A multisite randomized controlled study (48 weeks) among 120 YLWH newly starting ART will test the efficacy of the intervention compared to a control condition (who receive a non-HIV game and the Wisepill) on behavioral and biological measures. Information, Motivation, Behavioral Skills Adherence to ART Immersive iPhone Electronic, portable, 7-day medication game with text organizer/dispenser: measures adherence messaging integrates into iPhone gameHIV RNA Viral Load

尽管需要持续遵守医疗护理，但艾滋病毒（YLWH）的青年率很低依从性和保留护理，有可能失去后续行动的风险。（5,16-18）很棒需要对YLWH的新颖和吸引人的依从性干预措施。（7,8,14），我们开发了最初检查的是一种整合7天智能药物设备（Wisepill）的多层次技术具有吸引人且引人入胜的YLWH的身临其境且吸引人的智能手机应用程序/游戏。（82,83）在游戏玩法中，YLWH在色彩丰富和身临其境的器官系统中与HIV作斗争，并获得与依从性有关的带有游戏图形的短信。 Wisepill Openings指南与游戏相关的短信，并可能导致应用程序/游戏中的奖励积分。我们在开发试验中测试了多级游戏干预。这在新开始艺术的人中，干预的影响是最大的。在有新的参与者中开始艺术，干预措施降低了病毒载荷并改善了艺术依从性。那些刚开始艺术与对照中新启动的艺术相比，干预措施的经历了0.96的日志病毒载荷更大通过Wisepill衡量，减少并证明了改善依从性的较大效果（d = 1.18，71％Vs。在测试后的48％依从性）。干预与新开始艺术之间的这些相互作用非常重要在ANCOVAS中，考虑基线值（病毒载荷：F = 4.33，P = 0.04，粘附：F = 3.20，P = 0.05）。为了这下一个建议的研究阶段，我们将进一步测试与YLWH的多级游戏干预在新英格兰和密西西比州的临床场所新开始艺术。多站点随机对照研究（48周）在120 ylwh新开始的ART中，与对照相比，将测试干预措施的功效关于行为和生物学措施的条件（他们接受非HIV游戏和Wisepill）。信息，动机，行为技巧坚持艺术沉浸式iPhone 电子，便携式，7天药物带有文字的游戏组织者/分配器：衡量依从性消息传递集成到iPhone GameHiv RNA病毒负载