Integration of Electrophysiological and Behavioral Economic Models of Reward Among Heavy Drinking Emerging Adults

重度饮酒的新兴成年人奖励的电生理学和行为经济学模型的整合

• 批准号: 10172803
• 负责人: Samuel Fisher Acuff
• 金额: $ 3.68万
• 依托单位: UNIVERSITY OF MEMPHIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-05 至 2022-06-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10172803
• 关键词: Accidents; Acute; Alcohol consumption; Alcohols; Appointment; Award; Behavioral; Biological; Biological Markers; Cessation of life; Chronic; Clinical; Cognitive; Cues; Data; Data Analyses; Development; Diagnosis; Disease; Economic Models; Electroencephalogram; Electrophysiology (science); Elements; Event-Related Potentials; Feedback; Funding; Future; Gambling; Goals; Health; Heavy Drinking; Image; Individual; Intervention; Investigation; Lead; Learning; Legal; Link; Longitudinal Studies; Measures; National Institute on Alcohol Abuse and Alcoholism; National Research Service Awards; Outcome; Parents; Participant; Pathology; Pathway interactions; Patient Self-Report; Pattern; Population; Psychological reinforcement; Public Health; Reporting; Rewards; Risk; Stimulus; Strategic Planning; Stress; Time; Training; age group; alcohol cue; alcohol demand; alcohol free; alcohol measurement; alcohol misuse; alcohol related problem; alcohol use disorder; behavior test; behavioral economics; binge drinker; biobehavior; career; cohort; contextual factors; craving; discounting; drinking; drug misuse; emerging adult; follow-up; improved; incentive salience; indexing; millisecond; neuroeconomics; neurophysiology; pre-doctoral; preference; prospective; psychologic; recruit; response; reward processing; social; temporal measurement; theories; therapy development; vehicular accident

7. Project Summary/Abstract Alcohol misuse among emerging adults (age 18-25) is a major public health concern that results in acute and chronic consequences, such as blackouts, motor vehicle accidents, poorer career outcomes, disease, and death. Although many individuals “mature out” of heavy drinking, the determinants of positive drinking trajectories are unknown. Further, longitudinal studies examining these determinants often do not include biological indicators, inherently creating a gap between neuroscientific and clinical inquiries into alcohol misuse. Thus, as an adjunct study to an already funded longitudinal R01 (R01AA024930-01; Multiple PIs MacKillop & Murphy), we will recruit heavy drinking emerging adults (N = 95) at their 8-month follow-up appointment to engage in a single electroencephalogram (EEG) session measuring two event-related potential components that theoretically represent reward processing. Participants will then continue participation in the parent R01 and will complete follow-up self-report sessions at 12- and 16-months. Data collected from the EEG session will be used to predict changes in alcohol misuse (alcohol consumption, alcohol-related problems, and alcohol use disorder) at the 4- and 8-month follow-ups (i.e., the 12 and 16-month parent study follow-ups). The aims of the proposed project are: 1) to integrate electrophysiological indices (P3 and RewP) of alcohol, nonalcohol, immediate, and delayed reward into the ongoing longitudinal study to compare with self-report behavioral economic variables already included (i.e., alcohol demand, delayed discounting, substance-related relative to substance-free reinforcement); and 2) to explore prospective relations between event-related potentials, behavioral economic variables, and alcohol misuse. The study employs two paradigms for eliciting event-related potentials of reward processing: 1) oddball task (repetitive “common” stimulus presentation with dispersed “uncommon” images, for eliciting reactivity during uncommon images) for both nonalcohol and alcohol cues (P3); and 2) a doors task (gambling task in which participants make a choice between two doors with either positive or negative feedback about reward outcome) for both immediate and delayed rewards (RewP). During the award period, the applicant will undergo advanced training in alcohol misuse, electrophysiology, behavioral economics, neuroeconomics, and longitudinal data analysis, preparing the applicant for a career as an expert in behavioral economics and electrophysiology. This study provides a translational understanding of reward processing, an important mechanism related to alcohol-related pathology (NIAAA strategic plan Goal 1), and evaluates multiple indices of reward processing as predictors of alcohol misuse. This investigation may establish an electrophysiological biomarker of diminished alcohol-free reward response with the potential to improve the diagnosis and the prediction of the trajectory of alcohol use disorder (NIAAA strategic plan Goal 2). Results from this project will inform future efforts in behavioral economic theory and intervention development.

7. 项目总结/摘要 新兴成年人（18-25 岁）的酒精滥用是一个主要的公共卫生问题，会导致急性和 慢性后果，例如停电、机动车事故、职业生涯不佳、疾病和死亡。 尽管许多人因酗酒而“成熟”，但积极饮酒轨迹的决定因素是 此外，检查这些决定因素的纵向研究通常不包括生物指标， 因此，作为一种辅助手段，本质上在神经科学和临床研究之间造成了差距。 针对已资助的纵向 R01（R01AA024930-01；多个 PI MacKillop 和 Murphy）的研究，我们将招募 重度饮酒的新兴成年人 (N = 95) 在 8 个月的随访预约中参与单一活动 脑电图 (EEG) 会话测量两个与事件相关的电位分量，理论上 然后，参与者将继续代表参与父 R01 并完成。 从脑电图会议收集的数据将用于预测 12 个月和 16 个月的后续自我报告会议。 酒精滥用（酒精消耗、酒精相关问题和酒精使用障碍）的变化在 4- 以及 8 个月的随访（即 12 和 16 个月的家长研究随访）。 拟议项目的目标是：1）整合酒精的电生理指数（P3 和 RewP）， 将非酒精奖励、即时奖励和延迟奖励纳入正在进行的纵向研究中，以与自我报告进行比较 行为经济变量已包括在内（即酒精需求、延迟折扣、与物质相关的 相对于无物质强化）；2）探索事件相关之间的前瞻性关系 该研究采用了两种范式来引发。 奖励处理的事件相关潜力：1）奇怪的任务（重复的“常见”刺激呈现 对于非酒精和酒精，分散的“不常见”图像，用于在不常见图像中引发反应 提示（P3）；2）门任务（赌博任务，参与者在两扇门之间做出选择） 立即奖励和延迟奖励 (RewP) 的奖励结果的正面或负面反馈。 在奖励期间，申请人将接受酒精滥用、电生理学、 行为经济学、神经经济学和纵向数据分析，为申请人的职业生涯做好准备 行为经济学和电生理学专家，这项研究提供了对行为经济学和电生理学的转化理解。 奖励处理，与酒精相关病理学相关的重要机制（NIAAA 战略计划目标 1）， 并评估奖励处理的多个指标作为酒精滥用的预测因素。 建立无酒精奖励反应减少的电生理生物标志物，有可能 改善酒精使用障碍的诊断和轨迹预测（NIAAA 战略计划目标 2）。 该项目的结果将为行为经济理论和干预发展的未来努力提供信息。

项目成果

Posttraumatic stress disorder, drinking to cope, and harmful alcohol use: A multivariate meta-analysis of the self-medication hypothesis.

• DOI: 10.1037/abn0000764
• 发表时间: 2022-07
• 期刊: JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
• 作者: Luciano, Matthew T;Acuff, Samuel F;Olin, Cecilia C;Lewin, Rivian K;Strickland, Justin C;McDevitt-Murphy, Meghan E;Murphy, James G
• 通讯作者: Murphy, James G

Behavioral economics and the aggregate versus proximal impact of sociality on heavy drinking.

• DOI: 10.1016/j.drugalcdep.2021.108523
• 发表时间: 2021-03-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Acuff SF;Stoops WW;Strickland JC
• 通讯作者: Strickland JC

Reinforcer pathology of internet-related behaviors among college students: Data from six countries.

• DOI: 10.1037/pha0000459
• 发表时间: 2022-10
• 期刊: Experimental and clinical psychopharmacology
• 影响因子: 2.3
• 作者: Acuff SF;Pilatti A;Collins M;Hides L;Thingujam NS;Chai WJ;Yap WM;Shuai R;Hogarth L;Bravo AJ;Murphy JG
• 通讯作者: Murphy JG