Trace Elements (TE)

微量元素 (TE)

• 批准号: 10165517
• 负责人: Brian P Jackson
• 金额: $ 2.11万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10165517
• 关键词: Animal Organ; Arsenic; Beverages; Biological; Blood; Budgets; Cancer Center; Cancer Center Support Grant; Carcinogens; Catchment Area; Cells; Centers for Disease Control and Prevention (U.S.); Cereals; Chemicals; Chromatography; Coupled; Data; Data Analytics; Elements; Ensure; Exposure to; Fishes; Funding; Hair; Health Policy; Human; Individual; Inductively Coupled Plasma Mass Spectrometry; Infant; Inorganic Chemistry; Institution; International; Invertebrates; Iron; Link; Malignant Neoplasms; Measures; Methods; Monitor; NCI Center for Cancer Research; Norris Cotton Cancer Center; Nutrient; Placenta; Platinum; Play; Population Sciences; Preparation; Protocols documentation; Public Health; Quality Control; Research; Research Personnel; Resource Sharing; Resources; Role; Running; Sampling; Selenium; Services; Soil; Structure of nail of toe; Technology; Testing; Therapeutic Effect; Therapeutic Uses; Tissues; Trace Elements; Urine; Water; Work; analytical method; animal tissue; base; bioimaging; case-by-case basis; early life exposure; granite; instrument; instrumentation; member; nanoparticle; programs; quality assurance

Project Summary/Abstract: Trace Elements The chemistry of inorganic elements is linked inextricably with the study of cancer. This is especially true for our catchment area, given the high level of inorganic element exposures typical of “the Granite State”. Whether studying known carcinogens, such as arsenic, the potential antagonistic effects of elements, such as selenium, or the therapeutic uses of platinum or iron nanoparticles, there is a clear need for both routine and advanced trace element analytical methods to support NCCC research. The Trace Elements (TE) Shared Resource provides access to low-level inorganic elemental analysis to all four research programs within the Cancer Center. TE uses state-of-the-art ICP-MS instruments to quantify multiple elements and, when coupled with chromatography, multiple contaminant compounds (species) in a variety of biological and environmental media. Cutting-edge ICP-MS instrumentation (e.g., triple-quadrupole ICP-QQQ) provides rapid, interference- free analysis of established and emerging contaminants and macro- and micro-nutrient elements. The breadth of sample types handled by TE spans water, soil, sediment, invertebrates, fish and animal tissues and organs, cell lysates, human hair, toenail, blood, urine, placenta, foodstuffs, and beverages. The ability to handle such a broad array of sample types is a unique feature of TE. In some cases, the sample mass available for analysis is <10 mg, and methods often are adapted to account for small sample masses on a case-by-case basis. Analytical data must be collected according to accepted protocols for sample preparation, analysis, and quality control. TE has established protocols and a Quality Assurance program, uses methods based on those of the CDC, FDA, EPA, and USGS; and participates in national and international proficiency testing programs to ensure accurate, precise, and defensible data. TE has very strong links to the Cancer Population Sciences (CPS) Program. TE is an internationally-recognized center for low-level analysis of chemical elements and their compounds in biological tissues. TE has provided services for 27 other US academic institutions over the past funding cycle and fulfills a unique niche in providing state-of-the-art analytical services in trace elemental analysis. Over the last funding cycle, TE has run 6,721 samples for 12 NCCC Members from all 4 NCCC Programs (CPS [1], CBT [1], ICI [2], and TEC [8]). Funded NCCC Members have represented 15% (10) of Total Users, and we are requesting only 3% of the Total TE Budget from CCSG support. One focus of the CPS Program is early life exposure to arsenic, and TE is integral to the determination and speciation of arsenic for this project. This work has directly informed state and national public health policy. For example, the US FDA announced a proposed limit for inorganic arsenic in infant cereal of 100 ppb in 2016. For the TEC Program, TE provided a method for measuring iron nanoparticles in animal tissue. TE has contributed to CBT investigators monitoring the therapeutic effects of platinum. TE is demonstrably an essential, efficient and high-impact resource that continues to play a pivotal role in NCCC research.

项目摘要/摘要：微量元素 无机元素的化学与癌症研究有着千丝万缕的联系，对于癌症研究尤其如此。 鉴于“花岗岩州”典型的无机元素暴露水平较高，我们的流域是否如此。 研究已知的致癌物，例如砷，元素的潜在拮抗作用，例如硒， 或铂或铁纳米粒子的治疗用途，显然需要常规和高级 支持 NCCC 研究的微量元素分析方法。微量元素 (TE) 共享资源。 为癌症中心的所有四个研究项目提供低水平无机元素分析 TE 使用最先进的 ICP-MS 仪器来量化多种元素，并且与多种元素结合使用。 色谱法，多种生物和环境中的多种污染物化合物（种类） 尖端 ICP-MS 仪器（例如三重四极杆 ICP-MS/MS）可提供快速、干扰的检测。 免费分析已确定的和新出现的污染物以及大量和微量营养元素。 TE 处理的样品类型涵盖水、土壤、沉积物、无脊椎动物、鱼类和动物组织和器官， 细胞裂解物、人的头发、脚趾甲、血液、尿液、胎盘、食品和饮料。 广泛的样品类型是 TE 的独特功能。在某些情况下，样品质量可用于分析。 <10 mg，并且通常会根据具体情况调整方法以考虑小样本质量。 必须根据公认的样品制备、分析和质量协议收集分析数据 TE 制定了协议和质量保证计划，并使用基于这些协议和质量保证计划的方法。 CDC、FDA、EPA 和 USGS；并参与国家和国际能力验证计划 确保数据准确、精确且可靠。TE 与癌症人口科学有着非常密切的联系。 (CPS) 计划是国际公认的化学元素和低浓度分析中心。 TE 多年来已为其他 27 家美国学术机构提供服务。 过去的融资周期，并在提供最先进的痕量元素分析服务方面发挥了独特的作用 在上一个资助周期中，TE 为来自所有 4 个 NCCC 的 12 名 NCCC 成员运行了 6,721 个样本。 计划（CPS [1]、CBT [1]、ICI [2] 和 TEC [8]）资助的 NCCC 会员占 15% (10)。 用户总数，我们仅要求 CCSG 支持 TE 预算总额的 3%，这是 CPS 的重点之一。 项目是生命早期接触砷的过程，而 TE 是砷的测定和形态组成的组成部分 该项目直接为州和国家公共卫生政策提供信息。 2016 年宣布婴儿谷物食品中无机砷的拟议限值为 100 ppb。对于 TEC 计划，TE 提供了一种测量动物组织中铁纳米颗粒的方法，TE 为 CBT 研究人员做出了贡献。 TE 显然是一个重要、高效且具有高影响力的组织 继续在 NCCC 研究中发挥关键作用的资源。