Influences of the Efferent System on Human Auditory Function

传出系统对人类听觉功能的影响

• 批准号: 10168114
• 负责人: Skyler G. Jennings
• 金额: $ 5.14万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10168114
• 关键词: Acoustics; Action Potentials; Adult; Aging; Algorithms; Area; Auditory; Auditory Perception; Auditory system; Behavioral Research; Biomedical Research; Cochlea; Cochlear Hearing Loss; Code; Communication; Computer Models; Data; Detection; Development; Development Plans; Diagnostic Procedure; Discrimination; Disease; Ear; Electrophysiology (science); Elements; Environment; Family; Friends; Functional disorder; Funding; Goals; Hearing; Hearing Aids; Human; Impairment; Individual; Ipsilateral; Knowledge; Laboratory Animals; Lead; Link; Measures; Medial; Mentors; Methods; Mission; Modeling; National Institute on Deafness and Other Communication Disorders; Noise; Pathway interactions; Perception; Performance; Physiological; Principal Investigator; Procedures; Process; Productivity; Public Health; Quality of life; Reflex action; Rehabilitation therapy; Research; Research Methodology; Research Personnel; Research Support; Research Training; Role; Senior Scientist; Signal Transduction; Speech; Speech Discrimination; Speech Perception; Structure; System; Techniques; Training; Translating; Voice; base; career; career development; contrast enhanced; design; hearing impairment; human subject; improved; innovation; models and simulation; neurophysiology; normal hearing; novel; novel diagnostics; prevent; programs; rehabilitation strategy; relating to nervous system; response; signal processing; skills; sound; speech in noise

PROJECT SUMMARY/ABSTRACT Although current hearing devices improve listening in quiet environments, they do little to improve speech understanding in noisy backgrounds. The long-term goal of this research program is to fully understand the relationship between auditory perception and physiological mechanisms responsible for adapting to the local soundscape. The objective of this particular application is to understand the role of the medial olivocochlear (MOC) reflex in the perception of fluctuating sounds and on speech-in-noise performance in normal hearing and hearing impaired listeners using perceptual, electrophysiological, and auditory modeling techniques. The central hypothesis of the proposed research is that cochlear hearing loss limits the ability of the MOC reflex to regulate cochlear gain, thus preventing the putative perceptual and neural benefits associated with the reflex. The rationale of the proposed research is that a detailed description of the influence of the MOC reflex on human auditory function has the potential to translate to a better understanding of why hearing devices provide little benefit to improving speech-in-noise performance in hearing impaired adults. This detailed description will be obtained by completing the following specific aims: 1) Determine the role of the MOC reflex in the detection of temporal fluctuations and the identification of speech syllables in noise; 2) Determine the effect of eliciting the ipsilateral MOC reflex on the compound action potential (CAP) in human subjects with and without cochlear hearing loss; and 3) Simulate the influence of the MOC reflex on auditory function in listeners with and without cochlear hearing loss. This approach is innovative because it links empirical findings from normal and impaired perception and electrophysiology to a quantitative theoretical framework using a computational auditory model. The proposed research is significant because it is expected to lead to 1) a clear understanding of the role of the MOC reflex in humans with normal and impaired auditory systems, 2) effective procedures for evaluating the influence of the MOC reflex on auditory function, 3) novel MOC-inspired signal processing algorithms for hearing devices, and 4) a better quality of life for hearing impaired individuals by providing improved communication with family, friends, and co-workers. To achieve the research objectives of this application, the principal investigator (PI) has designed a career development plan to acquire expertise in speech perception and electrophysiological methods, and deepen expertise in computational auditory modeling. Training in these areas will be obtained by frequent communication and planned mentoring activities with senior scientists in the PI's mentoring/advising team. This training will provide the PI with the skills needed to become an independent investigator, and prepare for a career of research productivity.

项目摘要/摘要 尽管目前的听力设备改善了在安静的环境中的聆听，但它们对改善语音的作用并没有什么作用 在嘈杂的背景中理解。该研究计划的长期目标是充分了解 听觉感知与负责适应本地的生理机制之间的关系 音景。该特定应用的目的是了解内侧橄榄石的作用 （MOC）反射在正常听力中的波动声音和噪音表演中的反射 听力障碍者使用感知，电生理和听觉建模技术。这 拟议研究的中心假设是，人工耳蜗听力损失将MOC反射的能力限制为 调节人工耳蜗，从而防止了反射相关的假定感知和神经益处。 拟议的研究的理由是，对MOC反射的影响的详细描述 人类听觉功能有可能转化为更好地理解听力设备为什么提供的 在听力受损的成年人中改善语音表现的好处几乎没有好处。这个详细的描述将 可以通过完成以下特定目的来获得：1）确定MOC反射在检测中的作用 时间波动和噪声中语音音节的识别； 2）确定引起的效果 具有和没有人工耳蜗的人类受试者的复合动作电位（CAP）的同侧MOC反射 听力损失； 3）模拟MOC反射对听众中有或没有听觉功能的影响 耳蜗听力损失。这种方法具有创新性，因为它链接了正常和受损的经验发现 使用计算听觉模型对定量理论框架的感知和电生理学。 拟议的研究很重要，因为预计它将导致1）清楚地了解 具有正常和受损系统的人类的MOC反射，2）评估的有效程序 MOC反射对听觉功能的影响，3）新型MOC启发的信号处理算法 听力设备，以及4）通过提供改进的听力受损个人的生活质量更好 与家人，朋友和同事沟通。为了实现此应用程序的研究目标， 首席研究员（PI）设计了一项职业发展计划，以获取语音感知方面的专业知识 和电生理方法，并加深了计算听觉建模方面的专业知识。这些培训 领域将通过与高级科学家的经常沟通和计划指导活动来获得 PI的指导/咨询团队。该培训将为PI提供成为独立的技能 研究人员，为研究生产力做准备。

项目成果

A mathematical model for mechanical activation and compound action potential generation by the utricle in response to sound and vibration.

• DOI: 10.3389/fneur.2023.1109506
• 发表时间: 2023
• 期刊: Frontiers in neurology
• 影响因子: 3.4

Effects of Masker Envelope Fluctuations on the Temporal Effect.

掩蔽包络波动对时间效应的影响。

• DOI: 10.1007/s10162-018-00688-x
• 发表时间: 2018
• 期刊: Journal of the Association for Research in Otolaryngology : JARO
• 作者: Jennings,SkylerG;Sivas,Kayla;Stone,Caitlin
• 通讯作者: Stone,Caitlin

Firing Rate Adaptation of the Human Auditory Nerve Optimizes Neural Signal-to-Noise Ratios.

人类听觉神经的发射速率适应优化神经信噪比。

• DOI: 10.1007/s10162-022-00841-7
• 发表时间: 2022
• 期刊: Journal of the Association for Research in Otolaryngology : JARO
• 作者: Jennings,SkylerG;Dominguez,Juan
• 通讯作者: Dominguez,Juan

Middle ear muscle and medial olivocochlear activity inferred from individual human ears via cochlear potentials.

通过耳蜗电位从人耳个体推断中耳肌肉和内侧橄榄耳蜗活动。

• DOI: 10.1121/10.0017604
• 发表时间: 2023
• 期刊: The Journal of the Acoustical Society of America
• 作者: Jennings,SkylerG;Aviles,ElizabethSarai
• 通讯作者: Aviles,ElizabethSarai

Temporal Envelope Coding of the Human Auditory Nerve Inferred from Electrocochleography: Comparison with Envelope Following Responses.

从耳蜗电图推断的人类听觉神经的时间包络编码：与包络跟随响应的比较。

• DOI: 10.1007/s10162-022-00865-z
• 发表时间: 2022
• 期刊: Journal of the Association for Research in Otolaryngology : JARO
• 作者: Chen,Jessica;Jennings,SkylerG
• 通讯作者: Jennings,SkylerG