Health outcomes and cognitive effects of marijuana use among persons living with HIV/AIDS

吸食大麻对艾滋病毒/艾滋病患者的健康结果和认知影响

• 批准号: 10165870
• 负责人: Robert L Cook
• 金额: $ 14.88万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10165870
• 关键词: AIDS/HIV problem; Address; Adult; Affect; African American; Alcohol or Other Drugs use; Antibodies; Anxiety; Blood specimen; COVID-19; COVID-19 pandemic; Caring; Chronic; Chronic Disease; Cognitive; Continuity of Patient Care; Data; Data Collection; Dimensions; Economics; Enrollment; Epidemic; Family; Florida; Future; Goals; HIV; HIV Infections; Health; Immune system; Immunoglobulin G; Immunoglobulin M; Incidence; Infection; Inflammation; Interview; Link; Location; Longitudinal cohort; Measures; Mental Depression; Mental Health; Methods; Minority; Occupational; Outcome; Parents; Participant; Persons; Population; Post-Traumatic Stress Disorders; Prevalence; Prevention program; Preventive Intervention; Procedures; Research; Sampling; Sampling Studies; Severities; Social isolation; Substance Use Disorder; Surveys; Testing; Therapeutic; Time; Viral; Viral Load result; Visit; Vulnerable Populations; care outcomes; cognitive function; cohort; comorbidity; coronavirus disease; experience; follow-up; intervention program; marijuana use; marijuana use disorder; parent grant; psychosocial; public health emergency; social; surveillance data; treatment program

Abstract Persons living with HIV (PLWH) are an especially vulnerable population in the COVID-19 pandemic given their compromised immune system and comorbidities (e.g., substance use, mental health issues). Currently, no research has examined how the broad impacts of COVID-19 (e.g., extended social isolation, anxiety, family loss) are affecting marijuana use, cannabis use disorder (CUD), and care engagement in PLWH. Further, research has not clarified whether chronic marijuana use will interact with HIV infection to impact the onset and progression of COVID-19 infection. This urgent supplement will allow us to capture this window of opportunity and collect timely data to address these gaps. Our ongoing R01 study of a PLWH cohort focusing on marijuana use provides many unique strengths to support this supplement. The primary goal of the active R01 project is to examine the long-term impact of marijuana use on cognitive functioning and health outcomes in a cohort of PLWH (currently 300 participants completed baseline assessment) in Florida. This supplement is within the scope of the parent grant but extends the parent study by incorporating COVID-19-related questions/measures into the ongoing data collection. We will collect additional data using a mixed method approach which includes quantitative survey questions and in-depth qualitative interviews on a selected subsample. We will conduct COVID-19 antibody tests using the blood sample we collect as a part of the parent grant procedures. We will also link the collected data with the Florida Department of Health EHARS data on HIV-related outcomes (e.g., viral load) over time, which is also a part of the parent study. The specific aims of this supplement include: 1) To identify the impact of the COVID-19 pandemic on changes in marijuana use and cannabis use disorder (CUD) among PLWH; 2) To determine the impact of the COVID-19 pandemic on the HIV care continuum (i.e., HIV care engagement) and outcomes (i.e., viral load); and 3) To estimate the prevalence of COVID-19 infection in our study sample after September 2020, using antibody testing for IgG and IgM. If we have a large enough sample (i.e., 10% tested positive for COVID-19), we will examine the association between marijuana use status and COVID-19 incidence/severity. This study will be the first to address the impacts of the COVID-19 pandemic among an ongoing cohort of PLWH with a focus on marijuana use and its related health outcomes. By collecting additional COVID-19-related information as a part of the regular follow-ups in the parent study, we will be able to provide valuable evidence on how the COVID-19 pandemic may cause changes in PLWH’s marijuana use/CUD and HIV care/outcomes and will be able to identify the underlying mechanism of these changes. Results from the antibody tests may also provide informative data on whether marijuana use interacts with HIV in affecting COVID-19 incidence and severity, which can potentially inform future prevention and treatment programs for COVID-19 in this population.

抽象的 HIV 感染者 (PLWH) 是 COVID-19 大流行中特别脆弱的人群，因为他们的 免疫系统受损和合并症（例如药物滥用、心理健康问题）。 研究探讨了 COVID-19 的广泛影响（例如，长期的社会隔离、焦虑、家庭 损失）正在影响大麻使用、大麻使用障碍（CUD）以及 PLWH 的护理参与。 研究尚未阐明长期吸食大麻是否会与艾滋病毒感染相互作用，从而影响艾滋病毒的发病和 这份紧急补充文件将使我们能够抓住这一机会之窗。 并及时收集数据以弥补这些差距。我们正在进行的针对 PLWH 队列的 R01 研究重点关注。 大麻的使用提供了许多独特的优势来支持活性 R01 的主要目标。 该项目旨在研究吸食大麻对认知功能和健康结果的长期影响 佛罗里达州的 PLWH 队列（目前有 300 名参与者完成了基线评估）。 在家长补助金的范围内，但通过纳入与 COVID-19 相关的内容来扩展家长研究 我们将使用混合方法收集更多数据。 方法，包括定量调查问题和对选定的对象进行深入定性访谈 我们将使用我们收集的血液样本进行 COVID-19 抗体检测。 我们还将收集到的数据与佛罗里达州卫生部 EHARS 联系起来。 随着时间的推移，艾滋病毒相关结果（例如病毒载量）的数据，这也是母研究的一部分。 本补充文件的目的包括： 1) 确定 COVID-19 大流行对变化的影响 PLWH 中的大麻使用和大麻使用障碍 (CUD)；2) 确定 COVID-19 的影响 流行病对艾滋病毒护理连续性（即艾滋病毒护理参与）和结果（即病毒载量）的影响；以及 3) 使用抗体估计 2020 年 9 月后我们的研究样本中 COVID-19 感染的流行率 如果我们有足够大的样本（即 10% 的 COVID-19 检测呈阳性），我们将进行 IgG 和 IgM 检测。 这项研究将检查大麻使用状况与 COVID-19 发病率/严重程度之间的关联。 第一个解决 COVID-19 大流行对当前 PLWH 群体的影响，重点是 通过收集额外的 COVID-19 相关信息作为大麻使用及其相关健康结果。 作为家长研究定期随访的一部分，我们将能够提供有价值的证据，说明如何 COVID-19 大流行可能会导致 PLWH 的大麻使用/CUD 和 HIV 护理/结果发生变化，并将 抗体测试的结果也可以提供识别这些变化的潜在机制。 关于吸食大麻是否与 HIV 相互作用影响 COVID-19 发病率和严重程度的信息数据， 这可能为未来针对该人群的 COVID-19 预防和治疗计划提供信息。

项目成果

Need to Improve Dose Measurements in Studies of Marijuana Use for Pain.

需要改进大麻止痛研究中的剂量测量。

• DOI: 10.1097/qai.0000000000002238
• 发表时间: 2020
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Sajdeya,Ruba;Cook,RobertL
• 通讯作者: Cook,RobertL

Change in marijuana use and its associated factors among persons living with HIV (PLWH) during the COVID-19 pandemic: Findings from a prospective cohort.

• DOI: 10.1016/j.drugalcdep.2021.108770
• 发表时间: 2021-08-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Wang Y;Ibañez GE;Vaddiparti K;Stetten NE;Sajdeya R;Porges EC;Cohen RA;Cook RL
• 通讯作者: Cook RL