Longitudinal associations between neighborhood greenspace and brain aging in cognitively normal older adults

邻里绿地与认知正常老年人大脑衰老之间的纵向关联

基本信息

批准号：
10163112
负责人：
Lilah Besser
金额：
$ 12.64万
依托单位：
FLORIDA ATLANTIC UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-15 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10163112
关键词：
Address Adherence Affect Age Age-Years Aging Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease risk American Apolipoprotein E Archives Area Attention Behavior Biological Biology Brain Brain imaging Brain region Cerebrovascular Disorders Characteristics Clinical Cognition Cognitive Communities Coupled Data Data Collection Dementia Deterioration Development Development Plans Disease Educational process of instructing Elderly Environment Epidemiology Episodic memory Evaluation Exposure to Faculty Financial Support Florida Funding Genetic Risk Genotype Geographic Information Systems Geographic Locations Goals Green space Health Health Planning Health Professional Health Promotion Health behavior Hippocampus (Brain)Imagery Impaired cognition Individual Institution Interdisciplinary Study Intervention Investigation Knowledge Language Lead Learning Life Life Style Literature Longevity Longitudinal observational study Measures Memory Mentors Modeling Modification Motivation National Institute on Aging Neighborhoods Neurology Outcome Participant Personal Satisfaction Pharmacologic Substance Physical activity Play Population Privatization Public Health Publishing Questionnaires Race Research Research Personnel Research Support Risk Factors Scientist Socioeconomic Status Universities Vision Walking White Matter Hyperintensity aging brain aging in place brain health brain volume built environment career career development cerebral atrophy cognitive neuroscience cognitive reserve comorbidity cost critical period dementia risk demographics early onset executive function genetic risk factor good diet health data health disparity healthy lifestyle improved indexing innovation middle age mild cognitive impairment multidisciplinary novel prevent programs research study resilience sex skills skills training stress reduction supportive environment urban planning

项目摘要

PROJECT ABSTRACT No treatments are available to prevent Alzheimer’s disease, which currently affects 5.8 million Americans. Alzheimer’s risk can be reduced through healthy diets, stress reduction and physical activity, yet maintaining these can be difficult in practice due to cost and low motivation. Addressing these barriers, urban planning and public health researchers have evidenced neighborhood characteristics that promote health by offering amenities encouraging health behaviors such as walking. Greenspace (public and private areas with vegetation) is one such neighborhood feature previously associated with reduced Alzheimer’s risk and slower cognitive decline in the few published studies to date. Dr. Besser’s short-term research goal is to advance the research on this topic, to assess if neighborhood greenspace is associated with brain aging in older adults. The K01 specific aims are to determine if living in neighborhoods with greater vegetation and better access to parks in early, mid, and late-life is associated with slower rates of cognitive decline and less brain atrophy in cognitively normal older adults, and whether these associations vary by sex, race, apolipoprotein E genotype (genetic risk factor for Alzheimer’s disease), and geographic region. This longitudinal, observational study will combine clinical and brain volume data from three Alzheimer’s Disease Centers, a mailed questionnaire, and neighborhood greenspace measures derived using geographic information systems. Outcome variables will include cognitive domain (episodic memory, language, attention, executive function) and brain volume measures (hippocampal volume, white matter hyperintensities). Multi-level linear mixed models will account for neighborhood clustering and control for confounders (e.g., demographics, neighborhood socioeconomic status). The parallel career development plan involves: 1) learning to develop key neighborhood built environment and brain aging measures; 2) advancing and developing specialized primary data collection skills; 3) gaining knowledge in the biology and epidemiology of aging and cognitive neuroscience; 4) preparing and submitting the first R01 proposal; and 5) cultivating multidisciplinary collaborations. Dr. Besser’s institution, Florida Atlantic University, offers a highly supportive environment with all of the necessary faculty, teaching, financial, and research supports and rich opportunities for multidisciplinary and collaborative research. The primary mentor and co-mentor are experts in their respective fields of neurology/aging research and urban and regional planning. Dr. Besser’s institutional environment, career development plan, and specific aims are ideally suited to enable her long-term goal to become an expert and independent research scientist with an established, innovative, R01-funded research program focused on neighborhood built environments to support healthy brain aging.

项目摘要目前尚无预防阿尔茨海默病的治疗方法，该病目前影响着 580 万美国人。阿尔茨海默病的风险可以通过健康饮食、减轻压力和体育活动来降低，但同时保持由于成本和动力不足，这些在实践中可能很困难，解决这些障碍，城市规划和。公共卫生研究人员已经证明，通过提供促进健康的邻里特征鼓励健康行为的便利设施，例如步行的绿地（公共和私人区域）。植被）就是这样一种邻里特征，以前与降低阿尔茨海默病风险和减缓阿尔茨海默病风险有关迄今为止，在少数已发表的研究中，贝瑟博士的短期研究目标是推进认知能力下降。关于这一主题的研究，旨在评估社区绿地是否与老年人的大脑衰老有关。 K01 的具体目标是确定居住的社区是否拥有更多植被和更方便前往公园早年、中年和晚年的认知能力下降速度较慢，脑萎缩较少认知正常的老年人，以及这些关联是否因性别、种族、载脂蛋白 E 基因型而异（阿尔茨海默病的遗传风险因素）和地理区域这项纵向观察性研究将。结合来自三个阿尔茨海默病中心的临床和脑容量数据、邮寄调查问卷，以及使用地理信息系统得出的邻里绿地测量结果将。包括认知领域（情景记忆、语言、注意力、执行功能）和脑容量测量（海马体积、白质高信号）将考虑多级线性混合模型。邻域聚类和混杂因素控制（例如人口统计、邻域并行的职业发展计划包括：1）学习开发重点社区建设。环境和大脑老化措施；2）推进和发展专门的初级数据收集技能； 3）获得衰老生物学和流行病学以及认知神经科学方面的知识；4）准备和提交第一个 R01 提案；5) 培养 Besser 博士的机构，佛罗里达大西洋大学提供高度支持的环境，拥有所有必要的师资、教学、财政和研究支持以及多学科和协作研究的丰富机会。主要导师和共同导师是各自领域神经病学/衰老研究以及城市和 Besser博士的机构环境、职业发展计划和具体目标是非常适合实现她的长期目标，成为一名专家和独立研究科学家，已建立的、创新的、由 R01 资助的研究计划，重点关注社区建筑环境，以支持健康的大脑老化。