Longitudinal associations between neighborhood greenspace and brain aging in cognitively normal older adults

邻里绿地与认知正常老年人大脑衰老之间的纵向关联

• 批准号: 10163112
• 负责人: Lilah Besser
• 金额: $ 12.64万
• 依托单位: FLORIDA ATLANTIC UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10163112
• 关键词: Address; Adherence; Affect; Age; Age-Years; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease risk; American; Apolipoprotein E; Archives; Area; Attention; Behavior; Biological; Biology; Brain; Brain imaging; Brain region; Cerebrovascular Disorders; Characteristics; Clinical; Cognition; Cognitive; Communities; Coupled; Data; Data Collection; Dementia; Deterioration; Development; Development Plans; Disease; Educational process of instructing; Elderly; Environment; Epidemiology; Episodic memory; Evaluation; Exposure to; Faculty; Financial Support; Florida; Funding; Genetic Risk; Genotype; Geographic Information Systems; Geographic Locations; Goals; Green space; Health; Health Planning; Health Professional; Health Promotion; Health behavior; Hippocampus (Brain); Imagery; Impaired cognition; Individual; Institution; Interdisciplinary Study; Intervention; Investigation; Knowledge; Language; Lead; Learning; Life; Life Style; Literature; Longevity; Longitudinal observational study; Measures; Memory; Mentors; Modeling; Modification; Motivation; National Institute on Aging; Neighborhoods; Neurology; Outcome; Participant; Personal Satisfaction; Pharmacologic Substance; Physical activity; Play; Population; Privatization; Public Health; Publishing; Questionnaires; Race; Research; Research Personnel; Research Support; Risk Factors; Scientist; Socioeconomic Status; Universities; Vision; Walking; White Matter Hyperintensity; aging brain; aging in place; brain health; brain volume; built environment; career; career development; cerebral atrophy; cognitive neuroscience; cognitive reserve; comorbidity; cost; critical period; dementia risk; demographics; early onset; executive function; genetic risk factor; good diet; health data; health disparity; healthy lifestyle; improved; indexing; innovation; middle age; mild cognitive impairment; multidisciplinary; novel; prevent; programs; research study; resilience; sex; skills; skills training; stress reduction; supportive environment; urban planning

PROJECT ABSTRACT No treatments are available to prevent Alzheimer’s disease, which currently affects 5.8 million Americans. Alzheimer’s risk can be reduced through healthy diets, stress reduction and physical activity, yet maintaining these can be difficult in practice due to cost and low motivation. Addressing these barriers, urban planning and public health researchers have evidenced neighborhood characteristics that promote health by offering amenities encouraging health behaviors such as walking. Greenspace (public and private areas with vegetation) is one such neighborhood feature previously associated with reduced Alzheimer’s risk and slower cognitive decline in the few published studies to date. Dr. Besser’s short-term research goal is to advance the research on this topic, to assess if neighborhood greenspace is associated with brain aging in older adults. The K01 specific aims are to determine if living in neighborhoods with greater vegetation and better access to parks in early, mid, and late-life is associated with slower rates of cognitive decline and less brain atrophy in cognitively normal older adults, and whether these associations vary by sex, race, apolipoprotein E genotype (genetic risk factor for Alzheimer’s disease), and geographic region. This longitudinal, observational study will combine clinical and brain volume data from three Alzheimer’s Disease Centers, a mailed questionnaire, and neighborhood greenspace measures derived using geographic information systems. Outcome variables will include cognitive domain (episodic memory, language, attention, executive function) and brain volume measures (hippocampal volume, white matter hyperintensities). Multi-level linear mixed models will account for neighborhood clustering and control for confounders (e.g., demographics, neighborhood socioeconomic status). The parallel career development plan involves: 1) learning to develop key neighborhood built environment and brain aging measures; 2) advancing and developing specialized primary data collection skills; 3) gaining knowledge in the biology and epidemiology of aging and cognitive neuroscience; 4) preparing and submitting the first R01 proposal; and 5) cultivating multidisciplinary collaborations. Dr. Besser’s institution, Florida Atlantic University, offers a highly supportive environment with all of the necessary faculty, teaching, financial, and research supports and rich opportunities for multidisciplinary and collaborative research. The primary mentor and co-mentor are experts in their respective fields of neurology/aging research and urban and regional planning. Dr. Besser’s institutional environment, career development plan, and specific aims are ideally suited to enable her long-term goal to become an expert and independent research scientist with an established, innovative, R01-funded research program focused on neighborhood built environments to support healthy brain aging.

项目摘要 没有治疗方法可以防止阿尔茨海默氏病，这目前影响580万美国人。 通过健康的饮食，减轻压力和体育锻炼，可以降低阿尔茨海默氏症的风险 由于成本和动力低，在实践中可能很难。解决这些障碍，城市规划和 公共卫生研究人员已经证明了邻里特征，可以通过提供 设施鼓励诸如步行之类的健康行为。 Greenspace（公共和私人区域 植被）是以前与降低阿尔茨海默氏症风险和较慢有关的社区功能 迄今为止少数发表的研究的认知能力下降。贝塞尔博士的短期研究目标是促进 对此主题的研究，以评估邻里绿色空间是否与老年人的脑老化有关。 K01具体的目的是确定生活在植被更大的社区中，并更好地进入公园 在早期，中期和晚期，认知能力下降的速度较慢，大脑萎缩较少 认知正常的老年人，以及这些关联是否因性别，种族，载脂蛋白E基因型而异 （阿尔茨海默氏病的遗传危险因素）和地理区域。这项纵向，观察性研究将 来自三个阿尔茨海默氏病中心的临床和大脑量数据，邮寄问卷和 使用地理信息系统得出的邻里绿空间措施。结果变量将 包括认知领域（情节记忆，语言，注意力，执行功能）和大脑音量 措施（海马体积，白质超强度）。多级线性混合模型将考虑 混杂因素的邻里聚类和控制（例如人口统计学，社区社会经济 地位）。平行的职业发展计划涉及：1）学习开发建造的关键社区 环境和大脑老化措施； 2）提高和发展专门的主要数据收集技能； 3）在衰老和认知神经科学的生物学和流行病学方面获得知识； 4）准备和 提交第一个R01提案； 5）培养多学科合作。贝瑟博士的机构， 佛罗里达州大西洋大学，提供了一个高度支持的环境，并提供所有必要的教师，教学 财务和研究支持多学科和协作研究的丰富机会。 主要导师和联合学者是其各自神经/衰老研究领域的专家 区域计划。贝塞尔博士的机构环境，职业发展计划和具体目标是 非常适合使她的长期目标成为一名专家和独立的研究科学家 建立，创新，R01资助的研究计划着重于邻里建筑环境以支持 健康的大脑衰老。