Radioluminescence dosimetry solution for precision radiation therapy

用于精准放射治疗的放射发光剂量测定解决方案

基本信息

批准号：
10160833
负责人：
Lei Xing
金额：
$ 47.96万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10160833
关键词：
3D Print Algorithms Automation Biocompatible Coated Materials Calibration Cancer Patient Characteristics Clinic Clinical Clinical assessments Collaborations Collimator Communities Complex Consumption Country Data Data Analyses Data Collection Dose Electron Beam Ensure Environment Feedback Future High-Dose Rate Brachytherapy Image Imaging Techniques Incidence Industrialization Intensity-Modulated Radiotherapy Light Linear Accelerator Radiotherapy Systems Malignant Neoplasms Manuals Measurement Measures Methods Modality Modernization Monte Carlo Method Nature Operative Surgical Procedures Optics Patients Performance Photons Positioning Attribute Procedures Process Radiation Radiation Accidents Radiation Oncology Radiation therapy Research Roentgen Rays Safety Series Signal Transduction Software Tools Surface System Technology Testing Therapeutic Time Water Work analytical tool base checkpoint therapy chemotherapy clinical application clinical research site clinically translatable cost data acquisition design digital dosimetry human error image guided radiation therapy imaging system improved indexing novel novel strategies optical imaging palliation programs proton therapy prototype quality assurance real-time images response success therapy development tool

项目摘要

Radioluminescence dosimetry solution for precision radiation therapy Project summary Radiation therapy (RT) is an important modality for cancer management. Clinically, over 60% of all cancer patients in the US receive RT each year as therapy or for palliation, or as an adjunct to surgery or chemotherapy. There is also increased evidence that RT in combination with checkpoint immunotherapy is highly effective in treating a subset of cancer patients. In practice, however, because of the invisible nature of X-ray and its complex interaction process with media, how to ensure the geometric and dosimetric accuracy of incident RT beams presents a significant challenge in precision RT and critically determines the success of patient treatment. In this project, we form an academic-industrial collaboration to investigate and create a clinically translatable solution for substantially improved RT quality assurance (QA) using a radioluminescence imaging technique recently developed at Stanford. On the basis of our promising preliminary work, we hypothesize that the accuracy, efficacy and cost of geometric and dosimetric QA measurements of linear accelerators (LINACs) can be substantially improved with the use of radioluminecsnce imaging strategy. With the proposed research, we anticipate that submillimeter accuracy in geometric measurements and better than 3% accuracy in dosimetric measurements will be readily achievable with orders of magnitude less time and effort as compared to current practice, removing a major workflow bottleneck in clinical QA and reducing potential radiation treatment errors. This research presents a first-of-its-kind machine QA strategy capable of instantaneously measuring complex geometric and dosimetric characteristics of LINACs. If successful, the partnership will lead to a much safer and more efficient radiation oncology practice, and enable patients to truly benefit from modern RT modalities such as VMAT and IMRT and SBRT. In addition, the proposed strategy is quite general and the system developed here will also be valuable for QA applications of other treatment modalities, such as proton therapy and high-dose rate (HDR) brachytherapy.

用于精确放射治疗的辐射发光剂量测定溶液项目摘要放射疗法（RT）是癌症管理的重要方式。临床上，超过60％美国的癌症患者每年接受RT作为治疗或进行抑制，或作为手术或化学疗法。也有越来越多的证据表明RT与检查点免疫疗法结合在治疗一部分癌症患者方面非常有效。但是，实际上，由于无形 X射线的性质及其与媒体的复杂交互过程，如何确保几何和事件RT梁的剂量准确性提出了精确的RT的重大挑战，并且很严格确定患者治疗的成功。在这个项目中，我们组成了学术工业合作调查和创建可翻译的解决方案，以大大提高RT质量保证（QA）使用最近在斯坦福大学开发的放射性发光成像技术。基于我们有希望的初步工作，我们假设几何的准确性，功效和成本和成本线性加速器（LINAC）的剂量学质量测量值可以大大改善。放射性成像策略。通过拟议的研究，我们预计这是几何测量的准确性，剂量测量的准确性优于3％的精度与当前的练习相比，随着时间和精力的减少，很容易实现临床质量检查中的主要工作流瓶颈并减少了潜在的辐射处理错误。这研究提出了一种能够即时测量复杂的第一台机器QA策略 Linacs的几何和剂量计。如果成功，伙伴关系将导致很多更安全，更有效的辐射肿瘤学实践，使患者能够真正从现代RT中受益 VMAT和IMRT和SBRT等模态。此外，拟议的策略是相当一般的，此处开发的系统也将对于其他治疗方式的质量保证应用，例如作为质子疗法和高剂量率（HDR）近距离放射治疗。