Translational Alcohol Research Program (TARP)

转化酒精研究计划 (TARP)

• 批准号: 10159175
• 负责人: Kelly P Cosgrove
• 金额: $ 45.17万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10159175
• 关键词: alcohol research; programs

The goal of the Translational Alcohol Research Program (TARP) is to facilitate the ability of emerging post-doctoral researchers to bridge the gap in the application of knowledge gained from basic to clinical and social behavioral science research in alcohol use disorders (AUD) and alcohol- related liver disease (ALD). Both AUD and ALD are major public health problems and they should be considered together in the diagnosis and management of alcohol abuse and alcoholism. There is a gap in the application of knowledge f rom basic science studies to clinical models. This is particularly concerning given the establishment of a new generation of approaches (e.g., genomic, whole-body imaging) that allow the application of a `systems' approach to the study of AUD and ALD. It is of critical importance that future investigators are able to exploit these new research tools and approaches to accelerate the discovery and development of new treatments for ALD and AUD. The TARP is designed to improve clinical treatment of AUD and ALD by increasing the availability of appropriately-trained young scientists who are conversant in basic and clinical sciences and able to comfortably traverse the translational gap between these sciences. It is a two-year program offered by the Yale Schools of Medicine and Public Health and provides six post-doctoral trainees the opportunity to devote full-time effort during the initial phase of their careers to developing the skills and experience needed to become independent researchers in the field of translational research in AUD and ALD. The TARP has four main “content areas” viz. Reward Mechanisms; Stress and Negative Affect; Comorbidity (psychiatric and medical); and Alcoholic Liver Disease. The affiliation of TARP faculty with the NIAAA-funded Center for the Translational Neuroscience of Alcoholism and/or the Yale Liver Center enables the TARP trainees to conduct research that readily gravitates between preclinical projects (“bench”) and clinical and population health studies (“bedside” and “community”). Applicants will be MD or PhD post-doctoral candidates, trained in specialties including psychiatry, internal medicine, clinical psychology, public health, epidemiology, pharmacology, toxicology, or neuroscience. The TARP includes: 1) individualized, team- mentored research training, which includes successful completion of a translational-research project, 2) a core curriculum, including seminars on preclinical and clinical research and treatment, the medical consequences of excessive alcohol consumption, hepatology, metabolomics, biostatistics, responsible conduct of scientific research, and grant writing, 3) an individualized training and development plan (including participation in seminars of interest in associated departments and centers), 4) clinical and/or basic science training, and 5) training in effective communication and teaching. Upon completion, TARP graduates will be equipped to establish independent careers in translational research in AUD and ALD.

转化酒精研究计划 (TARP) 的目标是促进 新兴的博士后研究人员缩小了应用所获得知识的差距 酒精使用障碍（AUD）和酒精相关的临床和社会行为科学研究的基础 AUD 和 ALD 都是主要的公共卫生问题，应该予以重视。 在酒精滥用和酒精中毒的诊断和管理中综合考虑存在差距。 在将基础科学研究的知识应用于临床模型方面尤其如此。 关于建立新一代方法（例如基因组、全身 成像），允许应用“系统”方法来研究 AUD 和 ALD。 未来的研究人员能够利用这些新的研究工具和方法来 TARP 旨在加速 ALD 和 AUD 新疗法的发现和开发。 通过增加经过适当培训的年轻人的可用性来改善 AUD 和 ALD 的临床治疗 熟悉基础科学和临床科学并能够轻松地穿越世界的科学家 这些科学之间的翻译差距是耶鲁大学学院提供的一个为期两年的项目。 医学和公共卫生，并为六名博士后学员提供全职投入的机会 在职业生涯的初始阶段努力发展成为成为 AUD 和 ALD 领域的独立研究人员有四个主要的转化研究。 “内容领域”即奖励机制； TARP 教职人员与 NIAAA 资助的中心的隶属关系。 酒精中毒的转化神经科学和/或耶鲁大学肝脏中心使 TARP 学员能够 进行易于在临床前项目（“实验台”）与临床和人群之间进行的研究 健康研究（“床边”和“社区”）申请人将是医学博士或博士后候选人， 受过专业培训，包括精神病学、内科、临床心理学、公共卫生、 TARP 包括： 1) 个体化、团队化。 指导性研究培训，包括成功完成转化研究项目，2) 核心课程，包括临床前和临床研究与治疗、医学 过量饮酒的后果，肝病学，代谢组学，生物统计学，负责任 进行科学研究和撰写资助，3) 个性化的培训和发展计划 （包括参加相关部门和中心感兴趣的研讨会），4）临床和/或 基础科学培训，以及 5) 有效沟通和教学培训 完成后，TARP。 毕业生将有能力在 AUD 和 ALD 的转化研究中建立独立的职业生涯。