Wake Forest ADCC Administrative Supplement

维克森林 ADCC 行政补充

• 批准号: 10158830
• 负责人: SUZANNE CRAFT
• 金额: $ 15.22万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10158830
• 关键词: Academic Medical Centers; Achievement; Address; Administrative Supplement; Adult Respiratory Distress Syndrome; Advisory Committees; Agreement; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Attention; Blinded; COVID-19 pandemic; Clinical; Cognition; Cognitive; Consultations; Data; Data Collection; Data Set; Data Sources; Dementia; Development; Elderly; Enrollment; Episodic memory; Failure; Fatigue; Frail Elderly; Funding; Future; Goals; Gold; Hearing; Individual; Interruption; Interview; Language; Measures; Methodology; Methods; Modality; Neuropsychology; Participant; Persons; Population; Procedures; Psychometrics; Questionnaires; Request for Applications; Research; Rural Community; Rural Population; Short-Term Memory; Telephone; Test Result; Testing; Time; Transportation; Traumatic Brain Injury; Travel; Underserved Population; United States National Institutes of Health; Validation; Validity and Reliability; Videoconferences; Visit; adjudicate; adjudication; base; clinical center; clinical research site; cognitive testing; cohort; ethnic minority population; experience; falls; follow-up; forest; medical schools; mild cognitive impairment; programs; racial and ethnic; validation studies; working group

PROJECT SUMMARY This administrative supplement is proposed to fund the development of a cognitive battery based on the UDSv3 that can be administered by telephone or videoconference, and to provide preliminary feasibility and validation data to inform a future inter-ADRC validation study. The proposed supplement will be conducted in the Clinical Core cohort of the Alzheimer’s Disease Research Center (ADRC) at Wake Forest School of Medicine, and falls within the scope of the ADRC’s aims to provide in-depth clinical and cognitive characterization of this cohort. The proposal is based on evidence that telephone administration of cognitive tests and questionnaires is a practical, feasible approach that has been used successfully in other studies. Several batteries have been validated for phone use in a variety of populations, including older adults and those with mild cognitive impairment and dementia. However, a validated a telephone version of the new UDSv3 battery does not exist; alternative methods of ADRC data collection that yield valid information are needed. Our proposed supplement will lay critical groundwork for this endeavor. This project seeks to construct two brief adapted assessment batteries, a Core Battery and an Expanded Battery, that include portions of the in- person UDSv3 battery that can be administered remotely by telephone and video. We plan to administer remote assessments to 96 participants from the Wake Forest ADRC who have undergone in-person follow-up visits within the past six months. Participants will be assigned to telephone or video administration modalities, and each group will include participants previously adjudicated as having normal cognition, MCI, and Dementia. Participant ratings of acceptability, hearing quality, fatigue, and pleasantness of experience (compared to their past recollection of face-to-face experience) will be assessed using Likert-scale questionnaires for each condition. Qualitative assessment of what they liked and disliked will also be conducted. Total administration time, data completeness, refusal of a condition (telephone or video), or refusal to complete each test will be recorded. Participants’ cognitive status (normal, MCI or dementia) will be adjudicated using identical procedures to their face-to-face administrations, but adjudicators will be blinded to original adjudication status. We will also examine whether the associations among tests across cognitive domains vary by assessment mode. Agreements in adjudications will also be explored. Lastly, we will convene a group of experts in consultation with the NIA and the ADRC Clinical Task Force to develop plans for thorough psychometric validation of the batteries in conjunction with other ADRCs.

项目概要 该行政补充建议旨在资助电池的开发 基于UDSv3，可以通过电话或视频会议进行管理，并提供 初步可行性和验证数据可为未来的 ADRC 间验证研究提供信息。 拟议的补充将在阿尔茨海默病的临床核心队列中进行 维克森林医学院研究中心 (ADRC)，属于 ADRC 的目标是提供该队列的深入临床和认知特征。 该提案基于以下证据：测试和电话管理 问卷调查是一种实用、可行的方法，已在其他领域得到成功应用。 研究表明，多种电池可用于不同人群的手机使用， 包括老年人以及患有轻度认知障碍和痴呆症的人。 已验证电话版本的新型 UDSv3 电池不存在替代方法； 我们需要收集 ADRC 数据来提供有效信息。 该项目旨在构建两个简短的改编项目。 评估电池，核心电池和扩展电池，其中包括部分内部 我们计划通过电话和视频进行远程管理。 对来自维克森林 ADRC 的 96 名参与者进行远程评估 过去六个月内接受过现场随访的参与者将被分配到 电话或视频管理方式，每组将包括之前的参与者 被判定为具有正常认知、MCI 和痴呆症的参与者评级。 听力质量、疲劳度和体验的愉快程度（与他们过去的记忆相比） 面对面的经历）将使用针对每种情况的李克特量表问卷进行评估。 还将对他们喜欢和不喜欢的内容进行总体定性评估。 管理时间、数据完整性、拒绝条件（电话或视频）或拒绝 完成每项测试后，参与者的认知状态（正常、MCI 或痴呆）将被记录。 使用与其面对面管理相同的程序进行裁决，但裁决者 我们也会对协会的原始裁决情况不知情。 不同认知领域的测试之间的评估模式不同。 最后，我们将召集专家组与NIA进行协商。 ADRC 临床工作组制定计划，对患者进行彻底的心理测量验证 电池与其他 ADRC 结合使用。