Preventing Opioid Overdose Mortality in the United States

预防美国阿片类药物过量死亡

基本信息

批准号：
10164091
负责人：
Barrot Hopkins Lambdin
金额：
$ 16.44万
依托单位：
RESEARCH TRIANGLE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-15 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10164091
关键词：
2019-nCoV Adopted Affect Alcohol or Other Drugs use Buprenorphine COVID-19 COVID-19 pandemic Cessation of life Cities Communicable Diseases Communities Community based prevention County Cross-Sectional Studies Drug user Education Enrollment Future Geography Goals Grant Health Services Home environment Hour Human Resources Individual Injecting drug user Interview Knowledge Link Location Measures Methadone Modeling Naloxone Needle-Exchange Programs Opioid Overdose Participant Patients Persons Preparation Preventive Intervention Process Proliferating Public Health Reporting Rural Service delivery model Services Shelter facility Social Distance Surveys Syringes United States Virus base experience falls implementation science improved interest member mortality novel coronavirus operation opioid epidemic opioid overdose opioid use disorder overdose prevention pandemic disease prescription opioid prevent programs response screening service programs suburb transmission process

项目摘要

We are proposing an urgent competitive revision for our current grant (R01DA04686702) to study the impact of the novel coronavirus (COVID-19) pandemic on syringe service programs (SSPs) throughout the United States (US). The COVID-19 pandemic has rapidly proliferated and caused unprecedented disruption to health and health services in the US and has the potential to reverse recent reductions in the nation's opioid overdose mortality rate. As cities, counties, and states tried to stunt the transmission and impact of COVID- 19, they began rolling out various social distancing orders (e.g., Shelter-in-Place). A consequence of these public health mandates and the need to protect people from COVID-19 has been disruptions in services for people who inject drugs (PWID). Particularly in the context of the opioid epidemic, understanding how the COVID-19 pandemic has affected services for people who use drugs is critical to know how to respond within the current pandemic and to be better prepared for future public health crises. SSPs have been the mainstay for community-based prevention efforts for PWID and have pioneered efforts for implementing overdose education and naloxone distribution (OEND) and improving enrollment into medications for opioid use disorder (MOUD) programs. SSPs are considered an “essential service” and have not been mandated to suspend services during Shelter-in-Place orders. As part of our nationwide study of SSPs, our study team has documented that SSPs are facing unprecedented challenges and adapting implementations, as necessary. Leveraging our ongoing study, we propose to build a comprehensive understanding of adaptations made in response to COVID-19. Using the exploration, preparation, implementation, and sustainment (EPIS) framework, we propose to systematically assess the impacts of the COVID-19 pandemic on SSP services in the US. Our proposed aims are as follows: Aim 1: To characterize the response to COVID-19 regarding the delivery of syringe services, overdose education and naloxone distribution, and medications for opioid use disorder among SSPs; Aim 2: To describe barriers and facilitators among SSPs regarding implementation of syringe services, overdose education and naloxone distribution, and medications for opioid use disorder during the COVID-19 pandemic. To achieve these aims, we will conduct a cross-sectional study with all SSPs (N = 407) in the US in late summer/fall 2020. In addition, we will conduct in-depth interviews with 36 SSPs from geographically diverse urban, suburban, and rural locations where we observe varying levels of implementation experiences—de-implementation of services, adapted implementations, and implementation as usual—during the COVID-19 pandemic. Understanding how the COVID-19 pandemic has impacted services for PWID is critical for improving our response within the current pandemic and being better prepared for future pandemics.

我们提议对当前拨款 (R01DA04686702) 进行紧急竞争性修订，以研究其影响新型冠状病毒 (COVID-19) 大流行对整个美国注射器服务计划 (SSP) 的影响各州（美国）。COVID-19 大流行已迅速扩散，并造成了前所未有的破坏。美国的健康和卫生服务，并有可能扭转该国阿片类药物最近的减少趋势随着城市、县和州试图阻止新冠病毒的传播和影响，药物过量死亡率。 19 日，他们开始推出各种社交距离命令（例如“就地避难”）。公共卫生指令和保护人们免受 COVID-19 感染的需要已在服务中受到干扰特别是在阿片类药物流行的背景下，了解注射吸毒者（PWID）的情况。 COVID-19 大流行影响了为吸毒者提供的服务，了解如何应对至关重要在当前的大流行中，并为未来的公共卫生危机做好更好的准备是 SSP 的首要任务。吸毒者社区预防工作的支柱，并率先努力实施过量用药教育和纳洛酮分配 (OEND) 以及提高阿片类药物的注册率使用障碍 (MOUD) 计划被视为“基本服务”，并未被强制执行。作为我们全国 SSP 研究的一部分，我们的研究团队在“就地避难”期间暂停服务。已记录 SSP 面临挑战并调整实施，因为利用我们正在进行的研究，我们建议建立一个全面的了解。为应对 COVID-19 而进行的调整。可持续发展（EPIS）框架，我们建议系统地评估 COVID-19 大流行的影响我们提出的目标如下：目标 1：描述对 SSP 服务的响应。关于提供注射器服务、过量教育和纳洛酮分发的 COVID-19，以及 SSP 中治疗阿片类药物使用障碍的药物；目标 2：描述 SSP 中的障碍和促进因素关于注射器服务的实施、过量教育和纳洛酮分发，以及为实现这些目标，我们将开展针对新冠肺炎 (COVID-19) 大流行期间阿片类药物使用障碍的药物治疗。 2020 年夏末/秋季对美国所有 SSP (N = 407) 进行的一项横断面研究。此外，我们将对来自不同城市、郊区和农村地区的 36 个 SSP 进行深入访谈我们观察到不同程度的实施——服务的取消实施、调整实施，以及在 COVID-19 大流行期间照常实施。 COVID-19 大流行影响了注射吸毒者的服务，这对于改善我们在当前情况下的应对措施至关重要流行病并为未来的流行病做好更好的准备。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

How do contextual factors influence naloxone distribution from syringe service programs in the USA: a cross-sectional study.

DOI：
10.1186/s12954-023-00755-4
发表时间：
2023-02-28
期刊：
HARM REDUCTION JOURNAL
影响因子：
4.4
作者：
Lambdin, Barrot H.;Wenger, Lynn;Bluthenthal, Ricky;Bartholomew, Tyler S.;Tookes, Hansel E.;LaKosky, Paul;O'Neill, Savannah;Kral, Alex H.
通讯作者：
Kral, Alex H.

Availability of telehealth-based services at syringe services programs under the COVID-19 Public Health Emergency.

DOI：
10.1186/s12954-023-00861-3
发表时间：
2023-09-02
期刊：
HARM REDUCTION JOURNAL
影响因子：
4.4
作者：
Bartholomew, Tyler S.;Tookes, Hansel E.;Chueng, Teresa A.;Bluthenthal, Ricky N.;Wenger, Lynn D.;Kral, Alex H.;Lambdin, Barrot H.
通讯作者：
Lambdin, Barrot H.

Best practices for community-based overdose education and naloxone distribution programs: results from using the Delphi approach.

DOI：
10.1186/s12954-022-00639-z
发表时间：
2022-05-28
期刊：
HARM REDUCTION JOURNAL
影响因子：
4.4
作者：
Wenger, Lynn D.;Doe-Simkins, Maya;Wheeler, Eliza;Ongais, Lee;Morris, Terry;Bluthenthal, Ricky N.;Kral, Alex H.;Lambdin, Barrot H.
通讯作者：
Lambdin, Barrot H.

Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises.