Simultaneous functional MRI and Micro-Magnetic Nervous System Stimulation

同时进行功能性 MRI 和微磁神经系统刺激

基本信息

批准号：
10154562
负责人：
Ilknur Ay
金额：
$ 217.81万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10154562
关键词：
3-Dimensional Achievement Action Potentials Animals Area Axon Basic Science Biocompatible Materials Brain Brain imaging Calcium Channel Characteristics Charge Communities Corpus Callosum Data Deep Brain Stimulation Deposition Development Dimensions Dose Electric Stimulation Electromagnetics Elements Fiber Functional Magnetic Resonance Imaging General Hospitals Global Change Histology Inferior Colliculus Laboratories Magnetic Resonance Imaging Magnetism Massachusetts Measures Mediating Microscopic Nervous system structure Neural Pathways Neuraxis Neurons Neurosciences Research Optics Outcome Pathway interactions Peripheral Physiologic pulse Preparation Property Rattus Reaction Research Resistance Rodent Science Signal Transduction Source Structure Synapses System Technology Testing Time Tissues Transcranial magnetic stimulation Vagus nerve structure analog awake biocompatible polymer biomaterial compatibility brain tissue clinical application deep brain stimulation array deep brain stimulator design dorsal cochlear nucleus electric field flexibility hemodynamics implantation in vivo magnetic field neural network neural stimulation neuronal circuitry neuroregulation neurotransmission new technology next generation novel optical fiber optical imaging optical sensor optogenetics parylene prospective relating to nervous system response three dimensional structure tool white matter

项目摘要

ABSTRACT Micromagnetic stimulation (µMS) has several advantages over electrical stimulation. First, µMS does not require charge-balanced stimulation waveforms as in electrical stimulation. In µMS, neither sinks nor sources are present when the time-varying magnetic field induces a current. Thus µMS does not suffer from charge buildup as can occur with electrical stimulation. Second, magnetic stimulation via µMS is capable of activating neurons with specific axonal orientations. Third, it is contactless, so biocompatible materials such as parylene will allow implantation with minimal or no reaction. Moreover, as the probes can be insulated entirely from the brain tissue, we show to significantly reduce the problem of excessive power deposition into the tissue during magnetic resonance imaging (MRI). In this application, we propose to design, fabricate, and test microcoil structures for next-generation Nervous System Stimulation: the micro coils arrays will be designed for cortical stimulation like ECoGs and deep brain stimulation. The array will be novel in the sense that it will allocate optical fibers to perform onsite optogenetic calcium channels recording in awake and behaving animals, thus allowing for direct study of the underlying mechanisms of magnetic stimulation. All the micromagnetic stimulators will also be MRI compatible, allowing for large scale neural recordings with fMRI. This technology will serve Neuroscience research— investigating the function of neurons and neural networks in the peripheral and central nervous system (PNS and CNS)—enhancing or creating new applications for neuromodulation. All of these applications will allow us to employ neuromodulation and study how micromagnetic field pulses can be used for stimulating or blocking the flow of Action Potentials (APs) through the nervous system, as similarly transcranial magnetic stimulation (TMS) produces excitation and inhibition. The proposed µMS tools will also provide the community with a way to reach a more in-depth understanding of the mechanisms of actions of TMS.

抽象的微磁刺激 (μMS) 相对于电刺激有几个优点：首先，μMS 没有。与电刺激一样，需要电荷平衡的刺激波形，既不吸收也不产生源。当时变磁场感应电流时，μMS 不会受到电荷的影响。其次，通过 µMS 进行的磁刺激能够激活。第三，它是非接触式的，因此具有生物相容性材料，例如聚对二甲苯。此外，由于探针可以与物体完全绝缘，因此可以实现最小反应或无反应的植入。脑组织，我们证明可以显着减少在过程中过度功率沉积到组织中的问题磁共振成像（MRI）。在此应用中，我们建议设计、制造和测试下一代微线圈结构神经系统刺激：微线圈阵列将设计用于皮层刺激，如 ECoG 和该阵列将是新颖的，因为它将分配光纤进行现场执行。光遗传学钙通道记录清醒和行为动物，从而允许直接研究所有微磁刺激器也将与 MRI 兼容，允许使用功能磁共振成像进行大规模神经记录，这项技术将服务于神经科学研究—— 研究周围和中枢神经系统（PNS）中神经元和神经网络的功能和中枢神经系统）——增强或创建新的神经调节应用程序所有这些应用程序将使我们能够。采用神经调节并研究如何使用微磁场脉冲来刺激或阻断动作电位 (AP) 通过神经系统的流动，与类似的经颅磁刺激一样 (TMS) 产生兴奋和抑制。拟议的 µMS 工具也将为社区提供一种方法。更深入地了解TMS的作用机制。