Joint Study on the Development of Novel Joint Prostheses

新型关节假体开发联合研究

• 批准号: 10044165
• 负责人: MURAKAMI Teruo
• 金额: $ 2.5万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10044165/
• 关键词: Artificial Joint; Elastohydrodynamic Lubrication; Wear; Synovial Fluid; Artificial Joint Materials; Artificial Cartilage; Joint Simulator; Biotribology; バイオトラポロジー

The object of this research is to conduct the joint research between Kyushu University, The University of Leeds and University of Bradford to elucidate the lubrication and wear mechanism in artificial joints and develop novel joint prostheses. Members of this joint research visited Japan or United Kingdom for mutual discussion. Furthermore, during their visiting the presentations of papers on this research project were carried out at the international conferences, I.e., at the Third World Congress of Biomechanics, 25th Leeds-Lyon Symposium on Tribology, 1st Asia Int. Conf. on Tribology, Asiatrib'98, 26th Leeds-Lyon Symposium on Tribology and 12th International Symposium on Ceramics in Medicine. At the International Symposium on Lubrication Mechanism in Natural and Artificial Joints, which was organized by Prof. Murakami and Prof. Fisher at the 25th Meeting of Japanese Society of Clinical Biomechanics and Related Research, Dr. Jin and Dr. Sawae presented their papers as symposists.In th … More is joint study, the following results were shown. The fundamental mechanism in adaptive multimode lubrication in natural synovial joints was discussed by focusing the lubricating ability of cartilage surface layer. The geometric feature of knee joint was indicated by 3D Computer Graphics technique. On the lubrication mechanism in artificial joints, the fluid film formation, friction or wear in knee prosthesis models with compliant artificial cartilage such as polyurethane, silicone rubber, polyvinylalcohol (PVA) hydrogel and semi-interpenetrating polymer network (SIPN) hydrogel were evaluated by simulator or sliding tests. Atomic Force Microscopy (AFM) observation was effective in evaluation of changes in surface layer of natural articulator cartilage and artificial cartilage. The superiority in fluid film formation during walking for transverse elliptical conjunction to longitudinal one with the same contact area in knee prostheses was shown in numerical analysis. The friction and wear in existing artificial joints composed of metal or ceramics and ultra-high molecular weight polyethylene (UHMWPE), ceramics-on-ceramics, metal-on-metal were evaluated by unidirectional and multidirectional sliding tests and simulators. The influence of multi-directional motion, constituents of lubricants, material properties and geometrical design with surface roughness on wear behavior were summarized. The properties of wear particles and their biological reaction were investigated. The friction control of elastomeric material by applied electric field and wear reduction of metal-on-metal pair by magnetic field were demonstrated. Less

这项研究的目的是进行京都大学，利兹大学和布拉德福德大学之间的联合研究，以阐明人造关节中的润滑和磨损机制，并开发新的联合假体。这项联合研究的成员访问了日本或英国进行共同讨论。此外，在访问该研究项目的论文介绍期间，在国际会议上，即在第三届世界生物力学大会，第25届利兹 - 利兹 - 莉落摩擦学研讨会，第一亚洲。 conf。关于摩擦学，第26届利兹 - 利昂摩擦学研讨会和第12届医学陶瓷国际研讨会。在日本临床生物力学学会和相关研究协会第25届会议上，在自然和人造关节的国际润滑机制研讨会上，Jin和Sawae博士在第25届会议上组织了他们的论文作为符号。通过聚焦软骨表面层的润滑能力来讨论自适应多模润滑的基本机制。膝关节的几何特征通过3D计算机图形技术表示。关于人造关节的润滑机制，具有合规性软骨的膝盖假体模型中的流体膜形成，摩擦或磨损，例如聚氨酯，有机硅橡胶，聚乙烯基醇（PVA）水凝胶和半相互培养聚合物网络（SIPN）水凝胶（SIPN）水凝胶由Simulitor或Slidding Tests评估。原子力显微镜（AFM）观察有效评估天然枢纽软骨和人造软骨表面层的变化。在数值分析中显示了步行过程中流体膜形成的优越性，以侧椭圆形连接与纵向的纵向连接。通过单向和多方向滑动测试和模拟器评估了由金属或陶瓷以及超高分子量聚乙烯（UHMWPE），金属陶瓷，金属对金属的摩擦和磨损。总结了由润滑剂，材料特性和具有表面粗糙度的几何设计组成的多方向运动对磨损行为的影响。研究了磨损颗粒的特性及其生物反应。证明了通过施加的电场对弹性材料的摩擦控制，并通过磁场降低了金属对金属对的磨损。较少的

项目成果

T.Murakami: "Role of Surface Layers of Natural and Artificial Cartilage in Thin Film Lubrication"Lubrication at Frontier, Elsevier. 737-747 (1999)

T.Murakami：“天然和人造软骨表面层在薄膜润滑中的作用”前沿润滑，Elsevier。

Z. M. Jin: "Reducing Asperity Contact in UHMWPE Knee Joint Replacements through Improving Lubrication Mechanisms"Trans. International Conference on Knee Replacement 1974-2024. 2-24. 66-69 (1999)

金子明：“通过改进润滑机制减少 UHMWPE 膝关节置换术中的粗糙接触”，Trans。

Y.Nakanishi: "Improvement of Wear Characteristic of Metal-on-Metel Artificial Hip Joint by means of Magnetic Field"JSME International Journal.. Vol.42 No3. 552-559 (1999)

Y.Nakanishi：“通过磁场改善金属对金属人工髋关节的磨损特性”JSME 国际期刊.. Vol.42 No3。

Y. Sawae: "Improvement in Microstructure and Wear Property of Alumina Ceramics for Joint Prostheses"Bioceramics. Vol. 12. 99-103 (1999)

Y. Sawae：“关节假体用氧化铝陶瓷的微观结构和磨损性能的改善”生物陶瓷。

Y. Nakanishi: "Improvement of Wear Characteristic of Metal-on-Metal Artificial Hip Joint by means of Magnetic Field"JSME International Journal. Vol. 42, No. 3. 552-559 (1999)

Y. Nakanishi：“通过磁场改善金属对金属人工髋关节的磨损特性”JSME 国际期刊。