Epidemiological study on influence of micronutrients for occurring oral cancer -comparative study among different ethnic groups-

微量营养素对口腔癌发生影响的流行病学研究-不同民族间的比较研究-

基本信息

批准号：
09042011
负责人：
MIYAZAKI Hideo
金额：
$ 4.22万
依托单位：
Niigata University (1998)Aichi Gakuin University (1997)
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09042011/
关键词：
Oral cancer Leukoplakia Malaysia Micronutrients Carotenoid Betel quid chewing びんろう唯嚼口腔前癌病変疫学

项目摘要

For the selected subjects, epidemiological data of individual habit characteristics such as smoking, quid chewing and alcohol drinking were obtained from the same questionnaires recorded in the survey forms as for screening program. Venous blood samples were taken from subjects. Informed consent was obtained from all subjects (All selected subjects consented to this procedure by singing or thumb-printing the prepared consent form). The blood samples were centrifuged immediately to separate the serum from the cellular components. The serum samples were stored in -70℃ in freezer in University of Malaya prior to analysis of the serum micronutrients. The serum concentrations of retinol, α-tocopherol, lycopene, zeaxianthin/lutein , criptoxanthin, α-carotene, and β-carotene were determined using high performance liquid chromatography.The diagnostic criteria for oral precancer (leukoplakia, erythroplakia and oral submucos fibrosis were based on the recommendation by WHO in 1998. The diagnosti … More c criteria for lesions were also based on WHO in 1998 and criteria described by Axcell which were in accordance with the WHO's application of the International Classification of Diseases to Dentistry and Stomatology.The prevalence of oral mucosal lesions in Indians was 40.5% (N=255) . Oral cancer prevalence was 0.2% (1) , leukoplakia 10.9% (95) , lichen planus 0.7% (21) , oral submucous fibrosis 0.3% (13) , erythroplakia 0.5% (3) , chewer's mucosa 20.7% (133) and other non-OPC lesions 0.4% (13) . A multivariate analysis using logistic regression with OPC as the dependent variable showed significance for 2 independent variable namely, quid chewing and serum levels of α-carotene with 30.2 and 0.5 of odds ratio, respectively.In indigenous people in Sarawaku, the prevalence of oral mucosal lesions was 30.1% (N=203) . There were 23 (0.7%) subjects with OPC, 88 (14.3%) with chewer's mucosa and 129 (20.0%) with other non-OPC lesions. The OPC lesions consisted of 2 (0.3%) cases of oral cancer, 20 (0.3%) cases of oral leukoplakia, 1 (0.2%) case of oral submucous fibrosis.In Malays (N=276) , the prevalence of oral mucosal lesions was 20.3%. There were 4 (0.4%) subjects with OPC, 30 (10.3%) with chewer's mucosa and 21 (20.0%) with other non-OPC lesions. The OPC lesions consist of 2 (0.3%) cases of oral leukoplakia, 2 (0.2%) cases of oral lichen planus.The logistic regression analyses showed that the Indians are 8 times more likely to have OPC as compared to the Indigenous people. When oral leukoplakia was used as the dependent variable, significance for 2 independent variables were also evident namely, the Malays ethnicity and quid chewing. Similar to OPC, support for the bivariate analyses of positive correlation between oral leukoplakia and quid chewing was observed where subjects with quid chewing habit are significantly more likely to suffer from oral leukoplakia (coefficient=0.81), i. e., about 123 times more likely to have oral leukoplakia (odds ratio=120.6). This mulitvariate analysis also showed that Malays are significantly less likely to suffer from oral leukoplakia as compared to Indigenous people (coefficient=-0.245), i. e., the Malays are one-tenth times less to suffer from oral leukoplakia as compared to Indigenous people (odds ratio=0.106). The independent variable used here can only account for about 60% of oral leukoplakia as the dependent variable (Pseudo R2=0.603). Less

对于选定的受试者，从调查表中记录的相同问卷中获得了与筛查计划相同的问卷，从而获得了个体习惯特征的流行病学数据，例如吸烟，咀嚼和饮酒。静脉血液样本是从受试者中取出的。从所有受试者获得知情同意（所有选定的主题都通过唱歌或拇指打印准备的同意书同意本程序）。将血液样品离心，在分析血清微量营养素之前，将血清样品储存在马来亚大学的冰箱中-70℃中。使用高性能液相色谱法确定视黄醇，α-生育酚，番茄红素，番茄红素/叶黄素，核酸糖蛋白，核糖蛋白，核酸糖素，α-胡萝卜素和β-胡萝卜素的血清浓度。使用高性能液相色谱法确定了口腔诊断标准，口腔诊断标准（通过erythroplokia和the Oraloploplokia和Oral complibation the n98 the the n98 the in Conlation the n98 the Inclibers in th the n98 the Incleist in n98更多的病变标准还基于1998年的WHOS，Axcell描述的标准与WHO对牙科疾病的国际分类和口腔学的应用有关。印度人口腔粘膜病变的流行率为40.5％（n = 255）。（21），口服粘膜纤维化0.3％（13），赤型纤维化0.5％（3），咀嚼粘膜20.7％（133）和其他非OPC病变0.4％（13），使用OPC的多变量分析，是对2个自动级别的logistic Remission s and-creperive and-chew。萨拉瓦库的土著人分别为0.5，口腔粘膜病变的患病率为30.1％（n = 203）。有23名受试者（0.7％）患有OPC，88名（14.3％）的咀嚼粘膜和129（20.0％）和其他非OPC病变。 OPC病变包括2例（0.3％）口腔癌病例，20例（0.3％）口腔白细胞症，1例（0.2％）口服粘膜纤维化。有4个（0.4％）的OPC受试者，30名（10.3％）的咀嚼粘膜和21个（20.0％）的受试者和其他非OPC病变。 OPC病变包括2（0.3％）口服白细胞症，2（0.2％）口腔地衣平面病例。逻辑回归分析表明，与土著人民相比，印第安人拥有OPC的可能性高8倍。当口服白细胞用作因变量时，也证明了2个自变量的显着性，即马来人的种族和安静的咀嚼。与OPC相似，观察到对口腔白细胞和安静咀嚼之间正相关的双变量分析的支持，有安静咀嚼习惯的受试者更有可能患有口服白细胞liukoplakia（系数= 0.81）。例如，口服白细胞群的可能性高约123倍（优势比= 120.6）。这种穆尔氏菌分析还表明，与土著人（系数= -0.245）相比，马来人患有口腔白细胞的可能性要小得多，即与土著人相比，马来人患有口腔白细胞的十分之一倍（赔率= 0.106）。此处使用的自变量只能将大约60％的口服白细胞作为因变量（伪R2 = 0.603）。较少的