PHYSICAL EXERCISE AND BONE REMODELING : ANTHROPOLOGICAL RESEARCH FOR HEALTH SCIENCE IN AGING SOCIETY

体育锻炼和骨骼重塑:老龄化社会健康科学的人类学研究

基本信息

批准号：
09304077
负责人：
ISHIDA Hidemi
金额：
$ 19.26万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09304077/
关键词：
bone growth bone remodeling bone metabolism bone density cross section of long bone physical exercise Japanese macaque chimpanzee 霊長類四肢骨種間差

项目摘要

Studies of bone development and remodeling are concerned in various aspects of the human science, e.g., reconstruction of past lifestyle from excavated skeletons, growth of youth, and health science of the growing elderly population. However, basic data about bone material change associating with growth, variations of bone mass and distribution affected by aging and physical exercise have not been accumulated sufficiently. We used the Japanese macaque, one of the catarrhine monkeys which are closely related to humans, as a substitute model for humans to collect these basic data. Japanese macaques were adopted for this study because they are the most easily accessible primate in Japan and close to the rhesus macaque the standard experimental primates. In addition, its growth pattern and behavioral features have been well studied. We also collected same data from chimpanzees and examined interspecific differences. Beside experimental approach, we analyzed extensively skeletal adaptations in primates for different locomotor behaviors as well as those related induced mechanical loadings. We newly developed a high resolution micro pQCT (peripheral Quantitative Computed Tomography), Microscope Research SA (Norland-Stratech Co. Germany) for this study, which enabled very accurate measuring of bone density and mass. Despite the limited research term, we successfully collected basic data of bone material nature and mass change associated with growth and aging in Japanese macaque and chimpanzee by cross-sectional and longitudinal methods. Theses data have been presented in academic meetings such as International Symposium for Bone Metabolism (January 1998, Seattle), Annual Congress of the Japanese Anthropological Society, Annual Congress of the Primate Society of Japan.

关于人类科学的各个方面的骨骼发育和重塑的研究，例如，从开挖的骨骼，年轻人的成长以及不断增长的老年人群的健康科学中重建过去的生活方式。但是，尚未充分积累有关骨料变化与生长，骨骼质量和分布的变化相关的基本数据。我们使用了日本猕猴，这是与人类密切相关的卡他郡猴子之一，作为人类收集这些基本数据的替代模型。这项研究采用了日本猕猴，因为它们是日本最容易获得的灵长类动物，并且接近标准实验灵长类动物的恒河猴。此外，已经对其生长模式和行为特征进行了充分的研究。我们还从黑猩猩那里收集了相同的数据，并检查了种间差异。除了实验方法之外，我们还分析了针对不同运动行为以及那些相关诱导的机械负荷的灵长类动物的广泛骨骼适应。我们新开发了一项高分辨率微分PQCT（外围定量计算机断层扫描），显微镜研究SA（诺兰 - 斯特拉塔克公司德国），该研究使得非常准确地测量了骨密度和质量。尽管研究术语有限，但我们通过横截面和纵向方法成功收集了日本猕猴和黑猩猩的生长和衰老相关的骨骼物质性质和质量变化的基本数据。这些数据已在学术会议上介绍，例如国际骨代谢研讨会（1998年1月，西雅图），日本人类学学会的年度会议，日本灵长类动物学会的年度会议。