Ion Selective Transport Across Liquid Membrane Mimicking Renal Tubule Function

模拟肾小管功能的离子选择性跨液膜运输

• 批准号: 09450307
• 负责人: SAKAI Kiyotaka
• 金额: $ 1.09万
• 依托单位: Waseda University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09450307/
• 关键词: Artificial kidney; Dialysis; Urea; Ion; Electrodialysis; Extraction; Surfactant; Chelate

Further improvement of hemodialysis treatments with artificial kidney requires the development of a new renal tubule system that removes only uremic toxins from the blood, or recovers essential ions and solutes from outfiowing diatysate and returns them to the blood.The objective of the present study is to separate ions (Na^+, Cl^-) and urea and to recover the ions from the outfiowing dialysate. A potential difference was applied as a driving force using an ion selective liquid membrane to separate ions (Na^+, Cl^-) and urea and to concentrate the ions by dialysis. A PTFE membrane, impregnated with an organic solution in which reversed micelles were formed or chelate was dissolved was used as a liquid membrane. Using a reversed micelle liquid membrane, the transfer rate of Na^+ and Cl^- was higher than that of urea, and increased by applying the potential difference. Using a chelate liquid membrane, its membrane stability was higher than that of the reversed micelle liquid membrane. On … More the other hand, when no potential difference was applied, Na^+ and Cl^- permeated across the liquid membrane as fast as urea. Then a three chambers batch cell mimicking an electrodialysis apparatus was devised using the reversed micelle liquid membrane. When a potential difference was applied between outside two chambers as a driving force, Na^+ and Cl^- concentrations in the middle cell increased and urea concentration was kept to be constant. Therefore, repeated operation or continuous operation with the same cells connected makes it possible to separate ions (Na^+, Cl^-) and urea and concentrate ions (Na^+, Cl^-) efficiently.In conclusion, separation of ions (Na^+, Cl^-) and urea and concentration of ions (Na^+, Cl^-) in NaCI and urea solution with the three chambers batch cell are feasible using the reversed micelle liquid membrane, and the function of the renal tubule can be modeled and essential ions and solutes can be recovered from outflowing dialysate and returned to the blood. Less

通过人造肾脏对血液透析治疗的进一步改善需要开发一种新的肾块茎系统，该系统仅从血液中去除尿毒症毒素，或者从血液中恢复了必需离子和解决方案，从发出的伴呈水中并将其恢复为血液，目的是本研究的目的是分离离子（na^+，cl^ - ）和尿素（na^+，cl^ - ），以从疾病中恢复了疾病，并从疾病中恢复了疾病。使用离子选择性液体膜将电位差作为驱动力，以分离离子（Na^+，Cl^ - ）和尿素，并通过透析将离子浓缩。用有机溶液浸渍的PTFE膜，其中形成了反向胶束或溶解樱桃作为液体膜。使用反向的胶束液体膜，Na^+和Cl^ - 的转移速率高于尿素，并通过应用电势差来增加。使用樱桃液膜，其膜稳定性高于相反的胶束液体膜。另一方面，当没有施加电势差时，na^+和cl^ - 在液体膜上渗透到尿素中。然后使用反向的胶束液体膜设计了一个模仿电透析设备的三腔批处理细胞。当两个腔室之间的电势差作为驱动力时，中间细胞中的Na^+和Cl^ - 浓度会增加，尿素浓度保持恒定。因此，有效地与相同的单元连接的相同单元格的重复操作或连续操作可以有效地分离离子（Na^+，Cl^ - ）和尿素和浓度离子（Na^+，Cl^ - ）。膜，肾小管的功能可以进行建模，并且可以从输出透析液中回收必需离子和太阳能，并返回血液。较少的