Ion Selective Transport Across Liquid Membrane Mimicking Renal Tubule Function

模拟肾小管功能的离子选择性跨液膜运输

• 批准号: 09450307
• 负责人: SAKAI Kiyotaka
• 金额: $ 1.09万
• 依托单位: Waseda University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09450307/
• 关键词: Artificial kidney; Dialysis; Urea; Ion; Electrodialysis; Extraction; Surfactant; Chelate

Further improvement of hemodialysis treatments with artificial kidney requires the development of a new renal tubule system that removes only uremic toxins from the blood, or recovers essential ions and solutes from outfiowing diatysate and returns them to the blood.The objective of the present study is to separate ions (Na^+, Cl^-) and urea and to recover the ions from the outfiowing dialysate. A potential difference was applied as a driving force using an ion selective liquid membrane to separate ions (Na^+, Cl^-) and urea and to concentrate the ions by dialysis. A PTFE membrane, impregnated with an organic solution in which reversed micelles were formed or chelate was dissolved was used as a liquid membrane. Using a reversed micelle liquid membrane, the transfer rate of Na^+ and Cl^- was higher than that of urea, and increased by applying the potential difference. Using a chelate liquid membrane, its membrane stability was higher than that of the reversed micelle liquid membrane. On … More the other hand, when no potential difference was applied, Na^+ and Cl^- permeated across the liquid membrane as fast as urea. Then a three chambers batch cell mimicking an electrodialysis apparatus was devised using the reversed micelle liquid membrane. When a potential difference was applied between outside two chambers as a driving force, Na^+ and Cl^- concentrations in the middle cell increased and urea concentration was kept to be constant. Therefore, repeated operation or continuous operation with the same cells connected makes it possible to separate ions (Na^+, Cl^-) and urea and concentrate ions (Na^+, Cl^-) efficiently.In conclusion, separation of ions (Na^+, Cl^-) and urea and concentration of ions (Na^+, Cl^-) in NaCI and urea solution with the three chambers batch cell are feasible using the reversed micelle liquid membrane, and the function of the renal tubule can be modeled and essential ions and solutes can be recovered from outflowing dialysate and returned to the blood. Less

通过人为的人为发展的转化进一步改善了新的重现系统的发展，该系统只能从血液中remic毒素，或者恢复基本离子和溶质与偏置硅质的溶质并将其恢复为血液。 Cl^ - ）和尿素，从透析液中恢复离子的离子选择性液体。膜使用胶束液体，Na^+的转移速率高于尿素，而在电位差中增加了。使用电位差异，并闭合液体作为尿素。中间的Na^+和Cl^ - 浓度保持恒定，或连续运行相同的细胞可以分开（Na^+，Cl^ - ）和尿素和浓缩离子（ na^+，cl^）有效地。结论，使用反向的胶束液体membule，在NACI和尿素溶液中与Naci和尿素溶液中的离子分离（Na^+，Cl^）和+，Cl^ - ）在Naci和尿素溶液中的分离。可以建模，必要的离子和溶质可以从流出的透析液中回收并恢复到血液中。