EXTRACORPOREAL LING AND HEART ASSIST COMBINED WITH HYPOTHERMIA FOR BRAIN RESUSCITATION

体外灵和心脏辅助结合低温进行脑复苏

基本信息

批准号：
09470331
负责人：
TERASAKI Hidenori
金额：
$ 7.62万
依托单位：
KUMAMOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470331/
关键词：
cardiac arrest resuscitation extracorporeal circulation hypothermia membrane lung ECLHA cerebral resuscitation 模型人工肺

项目摘要

We have developed a new computer-assisted thermoregulator system to control the body temperature automatically from normothermia to 32ﾟC in dogs. The system could regulate hypothermia of 3 days with a slight aberrations of 0.4ﾟC and storage the data every one minute, including the temperatures, hemodynamics and the power spectrogram of EEG.The simultaneous measurement of temperatures in various portions of the body revealed that temperatures in the jugular venous blood, the cisterna magna and the pulmonary artery blood approximated the brain temperature. The rectal temperature correlated the brain temperature, but diarrhea and mucous stool during hypothermia sometimes caused the inaccurate temperature, leading to incorrect reflection of the brain temperature. These results certified that the temperature of the pulmonary artery blood was a most suitable means to observe the brain temperature closely during prolonged extracorporeal lung and heart assist (ECLHA) combined with mild hypothermia in dogs. ECLHA is frequently complicated with hemorrhage. Hypothermia also induces bleeding tendency. Thus we have examined the test of platelet aggregation and thromboelastogram. The test confirmed that the hypothermia of 32ﾟC within 24 h was unlikely to aggravate blood coagulation. Therefore we decided finally the resuscitation protocol of ECLHA combined with hypothermia of 32ﾟC limited within 24 h.The only ECLHA of 24 h combined with hypothermia of 32ﾟC resuscitated successfully dogs with cardiac arrest of 15 min without neurologic sequlae. The further studies will be required to establish ECLHA combined with hypothermia as a means for resuscitation.

我们已经开发了一种新的计算机辅助热调节器系统，以自动控制狗的体温，从狗的温度自动控制到32°C。该系统可以调节3天的体温过低，略有略微像差为0.4 c c，并每分钟存储数据，包括温度，血液动力学和EEG的功率谱。直肠温度与大脑温度相关，但是体温过低期间的腹泻和粘液粪便有时会导致温度不准确，从而导致大脑温度的反射不正确。这些结果证明，肺动脉血的温度是最合适的方法，可以在长时间的体外肺和心脏辅助（ECLHA）结合狗中的轻度体温过低期间密切观察大脑温度。 ECLHA经常因出血而复杂。体温过低还引起趋势。我们已经检查了血小板聚集和血栓形成的测试。该测试证实，24小时内32°C的体温过低不太可能加剧血液凝结。因此，我们最终决定了ECLHA的复苏方案，结合了24小时内的32°C限制的低温限制。唯一的ECLHA 24小时的ECLHA结合了32°C的32°C复苏，无神经学Sequlae的心脏骤停成功地恢复了15分钟。需要进一步的研究来建立ECLHA与体温过低，作为复苏的一种手段。