EXTRACORPOREAL LING AND HEART ASSIST COMBINED WITH HYPOTHERMIA FOR BRAIN RESUSCITATION

体外灵和心脏辅助结合低温进行脑复苏

基本信息

批准号：
09470331
负责人：
TERASAKI Hidenori
金额：
$ 7.62万
依托单位：
KUMAMOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470331/
关键词：
cardiac arrest resuscitation extracorporeal circulation hypothermia membrane lung ECLHA cerebral resuscitation 模型人工肺

项目摘要

We have developed a new computer-assisted thermoregulator system to control the body temperature automatically from normothermia to 32ﾟC in dogs. The system could regulate hypothermia of 3 days with a slight aberrations of 0.4ﾟC and storage the data every one minute, including the temperatures, hemodynamics and the power spectrogram of EEG.The simultaneous measurement of temperatures in various portions of the body revealed that temperatures in the jugular venous blood, the cisterna magna and the pulmonary artery blood approximated the brain temperature. The rectal temperature correlated the brain temperature, but diarrhea and mucous stool during hypothermia sometimes caused the inaccurate temperature, leading to incorrect reflection of the brain temperature. These results certified that the temperature of the pulmonary artery blood was a most suitable means to observe the brain temperature closely during prolonged extracorporeal lung and heart assist (ECLHA) combined with mild hypothermia in dogs. ECLHA is frequently complicated with hemorrhage. Hypothermia also induces bleeding tendency. Thus we have examined the test of platelet aggregation and thromboelastogram. The test confirmed that the hypothermia of 32ﾟC within 24 h was unlikely to aggravate blood coagulation. Therefore we decided finally the resuscitation protocol of ECLHA combined with hypothermia of 32ﾟC limited within 24 h.The only ECLHA of 24 h combined with hypothermia of 32ﾟC resuscitated successfully dogs with cardiac arrest of 15 min without neurologic sequlae. The further studies will be required to establish ECLHA combined with hypothermia as a means for resuscitation.

我们开发了一种新的计算机辅助体温调节系统，可以将狗的体温从正常体温自动控制到32°C，该系统可以调节3天的低温，误差为0.4°C，并且每分钟存储一次数据，包括。温度、血流动力学和脑电图功率谱图。同时测量身体各个部位的温度显示颈静脉血、脑池的温度直肠温度与脑温度近似，但体温过低时的腹泻和粘液粪便有时会导致温度不准确，从而导致脑温度的错误反映。动脉血是长时间体外肺心辅助（ECLHA）期间密切观察脑部温度的最合适的方法，并且ECLHA经常并发出血，低体温也会引起出血。因此我们检查了血小板聚集和血栓弹力图，结果证实24小时内32℃的低温不太可能加重凝血，因此我们最终决定了ECLHA联合32℃低温的复苏方案。仅限24小时内，唯一24小时ECLHA联合32℃低温复苏成功心脏骤停 15 分钟且无神经系统后遗症的狗需要进一步研究以确定 ECLHA 与低温联合作为复苏手段。