Development of Sustained-Release Container and High-performance Adsorbent of Pesticide Using Chitosan

壳聚糖农药缓释容器及高性能吸附剂的研制

基本信息

批准号：
09650848
负责人：
YOSHIZUKA Kazuharu
金额：
$ 1.92万
依托单位：
Saga University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

Using Chitosan being a hydrolyzed derivative of chitin distributed in nature as a fundamental component of shells of crustaceans and insects and plant cell walls, we prepared two types of chitosan microparticles (CMs)and membranes and CMs complexed with Ag(I) and some platinum group metal ion (SCMs) using different crosslinking agents, i.e., glutaraldehyde and epichlorohydrin. Using these microparticles and membranes we ave investigated and compared the absorption and release behavior of a typical pesticide, methyl parathion (MP).The obtained results are as follows :(1) Using chitosan membrane and DOLSA-chitosan hybrid membranes, we investigated the permeation and sustained-release mechanism of platinum group metal which is the anti-tumor drug.(2) From the pH and concentration dependencies of Ag (I) and MP adsorption onto both the CMs and SCMs, the epichlorohydrin-crosslinked CM apparently showed the superiority of Ag (I) adsorption over the glutaraldehyde-crosslinked CM, nevertheless, adsorption behavior of NIP onto SCM derived from each CM were observed in reverse.(3) Release behavior of MP from the methyl parathion-loaded SCMs were also observed by aqueous buffer solutions of acetic acid and sodium acetate of low pH as well as by that containing some complexing reagents. The results suggested that the aqueous solutions containing ammonium thiocyanide (NH_4SCN) and ammonia (NH_40H) could be applied for MP release from the MP-loaded SCMs without the silver leackage from the particles.(4) We investigated the adsorption and elusion behaviors of NIP through the column packed SCMs, to elucidate the influences of pH of aqueous solution, NIP concentration and loading amount of Ag (I) on SCMs on maximal loading amount and adsorption and elusion rates of MP We have found that SCM crosslinked by glutaraldehyde has high durability of repeating column operation with reversible adsorption and elusion of MP.

我们使用壳聚糖是在自然界中分布的几丁质的水解衍生物，作为甲壳类动物，昆虫和植物细胞壁的壳的基本成分，我们准备了两种类型的壳聚糖微粒（CMS），膜和膜和CMS与AG（I）和某些铂类组复杂化金属离子（SCM）使用不同的交联剂，即戊二醛和环氯二醇。使用这些微粒和膜，我们研究并比较了典型农药，甲基parathion（MP）的吸收和释放行为。获得的结果如下：（1）使用壳聚糖膜和Dolsa-Chitosan膜和Dolsa-Chitosan杂种杂交膜，我们研究了渗透率铂金属的持续释放机制，即抗肿瘤药物。（2）来自Ag（I）的pH和浓度依赖性，并吸附在CMS和SCMS上，Epichloro Hydrin-跨链蛋白 - 互联链接CM显然显示出优势Ag（i）在戊二醛交联的CM上的吸附，但是，反向观察到NIP在每个CM中的SCM的吸附行为。低pH的乙酸和乙酸钠的溶液以及含有一些络合试剂的溶液。结果表明，含有硫氰化铵（NH_4SCN）和氨（NH_40H）的水溶液可用于从MP负载的SCMS中释放MP，而没有颗粒的银色Leckage。通过列填充的SCM，为了阐明水溶液的pH值，在最大负载量和MP的最大负载量以及MP的吸附速率上，NIP浓度和AG（I）的加载量，我们发现SCM通过戊二醛交联具有很高的耐用性重复柱操作，具有可逆的MP的吸附和催化。