A STUDY OF SMALL FIBER NEUROPATHY BY EVALUATING THE THRESHOLD OF THERMAL SENSATION USING HEAT FLUX

通过使用热通量评估热感觉阈值来研究小纤维神经病

• 批准号: 09670673
• 负责人: OKA Hisayoshi
• 金额: $ 0.96万
• 依托单位: JIKEI UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670673/
• 关键词: HEAT FLUX; THERMAL SENSATION; SMALL FIBER NEUROPATHY; DIABETIC NEUROPATHY; UNMYELINATED FIBER; AXONAL DEGENERATION; 小径有髄神経; 末梢神経障害; 体性神経; 神経伝導検査; 皮膚温度感覚閾値検査法

We estimated small fiber neuropathy by measuring the threshold of thermosensation in diabetic neuropathy using a new technique based on heat flux, which indicates the movement of heat energy. The subjects were 20 healthy controls and 20 diabetic patients. A thermostimulator operating on the Peltier principle was attached to the thenar skin area of the hand and its temperature was increased or decreased by 0.2℃ per second unitl the subject felt a warm or cold sensation. The warm heat flux (WHF J/mィイD12ィエD1) and cold heat flux (CHF J/mィイD12ィエD1) were calculated by integrating each heat flux until it felt warm or cold respectively. The WHF of healthy controls was 40 J/mィイD12ィエD1 and the CHF was indicated 59 J/mィイD12ィエD1. The WHF of diabetic patients (115 J/mィイD12ィエD1) was significantly larger than that of controls. The CHF of diabetic patients (170 J/mィイD12ィエD1) was also significantly larger than that of controls. The measuring the threshold of thermosensation using the new technique based on heat flux is beneficial to estimate small fiber dysfunction in diabetic neuropathy.

我们通过使用基于热通量的新技术测量糖尿病神经病变的热感觉阈值来估计小纤维神经病变，该技术指示热能的运动，其中健康受试者为 20 名对照者和 20 名糖尿病患者。贴在手的大鱼际皮肤区域，其温度每秒升高或降低 0.2℃，直到受试者感到温暖或寒冷。 温暖的热流（WH​​F）。 J/mID12D1) 和冷热通量 (CHF J/mID12D1) 通过对每个热通量进行积分计算，直到分别感到温暖或寒冷。健康对照的 WHF 为 40 J/mD12D1，CHF 为 59 J/mD12D1。糖尿病患者的 WHF (115 J/mD12D1) 为糖尿病患者的CHF（170 J/m2D1）也显着大于对照组，使用基于热通量的新技术测量热感觉阈值有利于估计糖尿病神经病变中的小纤维功能障碍。