Investigation and biosensing application of novel switching function in conductive polymer hydrogels

导电聚合物水凝胶新型开关功能的研究及生物传感应用

• 批准号: 22KF0095
• 负责人: 坂田 利弥
• 金额: $ 1.47万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2023
• 资助国家: 日本
• 起止时间: 2023-03-08 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KF0095/
• 关键词: electrochemical sensing; PEDOT

Using UV-Vis-NIR spectroelectrochemistry, we studied the interaction of PEDOT during redox cycling of quinones from bound catechol functional groups in a composite polymer. Whereas PEDOT absorbance band shifts from visible (550 nm) to IR (>900nm) wavelengths during oxidation and reduction, respectively, quinone bands shift from visible (400 nm) to UV (280 nm). Thus, the oxidation state of redox active components and their relative proportions can be followed in-situ. Repeated cycling in physiological buffer conditions found an unexpected accumulation of oxidized PEDOT and reduced catechol, suggesting the formation of a charge-transfer complex between the two species.Using flexible polyimide substrates, we successfully fabricated devices with suspended channels. Access to electrolyte from top and bottom sides of the hydrogel reduced the effective thickness by half resulting in improved mass transport. Accordingly, the cut-off frequency in the response of a hydrogel transistor amplifier was doubled and the rate of electrocatalyzed oxygen reduction reaction was improved. This new device structure facilitates the use of AC impedance spectroscopy to control the kinetics involved in the evolution of an electrochemical sensing signal.

利用紫外-可见-近红外光谱电化学，我们研究了复合聚合物中结合儿茶酚官能团的醌氧化还原循环过程中 PEDOT 的相互作用。 PEDOT 吸收带在氧化和还原过程中分别从可见光 (550 nm) 转移到红外 (>900 nm) 波长，而醌吸收带从可见光 (400 nm) 转移到紫外 (280 nm)。因此，可以原位跟踪氧化还原活性组分的氧化态及其相对比例。在生理缓冲条件下的重复循环发现氧化PEDOT和还原儿茶酚的意外积累，表明这两个物种之间形成了电荷转移复合物。使用柔性聚酰亚胺基板，我们成功地制造了具有悬浮通道的器件。从水凝胶的顶部和底部接触电解质使有效厚度减少一半，从而改善质量传输。因此，水凝胶晶体管放大器响应的截止频率加倍，电催化氧还原反应的速率提高。这种新的器件结构有助于使用交流阻抗谱来控制电化学传感信号演变中涉及的动力学。

项目成果

Small Biomolecular Detection Based on Small-Signal Transconductance of Suspended Double-Network Hydrogels as Organic Electrochemical Transistors

基于悬浮双网络水凝胶作为有机电化学晶体管的小信号跨导的小生物分子检测

• 发表时间: 2022
• 作者: TSENG Alex Chi-Wei;坂田利弥
• 通讯作者: 坂田利弥