Development of Closed-loop Implantable Focal Brain Cooling System for non-human primates

用于非人类灵长类动物的闭环植入式局部脑冷却系统的开发

• 批准号: 24700497
• 负责人: MORIHIRO Yusuke
• 金额: $ 2.83万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700497/
• 关键词: 霊長類; マカクザル; ネコ; 局所脳冷却; てんかん; サル; 埋込みデバイス; ペルチェ素子; ペルチエ素子; 体内埋め込み

Focal brain cooling has the therapeutic potential to various neurological diseases such as epilepsy. In this study, I developed a implantable cooling device that can be achieved with closed-loop system.The cooling device composed of a PID-controlled, thermoelectric chip for cooling the brain and a reservoir for dissipating heat from the device. Semi-implantation of the cooling system in cats indicated the system could be controlled target temperature. Then the device was modified and implanted in adult monkey. However, a limitation of cooling performance was seen. Spike detection method based on frequency analysis was the effective seizure detection by applying the optimal noise reduction. In the future, I'm considering the implementation of the analysis using the complex demodulation method and empirical mode decompression.The results potentially supported the technical feasibility of thermal neuromodulation based on the implantable focal brain cooling device.

局部脑冷却具有治疗癫痫等多种神经系统疾病的潜力。在这项研究中，我开发了一种可以通过闭环系统实现的植入式冷却装置。该冷却装置由用于冷却大脑的PID控制的热电芯片和用于散发装置热量的储液器组成。冷却系统半植入猫体内表明该系统可以控制目标温度。然后该装置被修改并植入成年猴子体内。然而，冷却性能受到限制。基于频率分析的尖峰检测方法是应用最佳降噪的有效癫痫检测。未来，我正在考虑使用复杂解调方法和经验模式减压来实施分析。结果可能支持基于植入式局灶性脑冷却装置的热神经调节的技术可行性。

项目成果

Fatty acid binding protein 7 as a marker for glioma stem cells.

脂肪酸结合蛋白 7 作为神经胶质瘤干细胞的标记物。

• DOI: 10.1111/pin.12109
• 发表时间: 2013
• 影响因子: 2.2
• 作者: Morihiro; Y.; Yasumoto; Y.; Koshy; VL.; Sadahiro; H.; Uchida; T.; Inamura; A.; Sharifi; K.; Ideguchi; M.; Nomura; S.; Tokuda; N.; Kashiwabara; S.; Ishii; A.; Ikeda; E.; Owada ; Y. *;Suzuki; M. (* corresp. author)
• 通讯作者: M. (* corresp. author)