Preparation and Biomechanics of High-performance Artificial Bones Containing

高性能人工骨的制备及其生物力学

• 批准号: 09680851
• 负责人: KASUGA Toshihiro
• 金额: $ 1.66万
• 依托单位: Nagoya Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09680851/
• 关键词: Glass-Ceramic; Calcium phosphate; Fiber; Polylactic acid; Artificial bone; Young's modulus; Composite; Biomaterial; 結晶化ガラス

Novel biomaterials for application to artificial bone with modulus of elasticity close to that of natural bone were prepared using bioresorbable poly-L-lactic acid (PLA) and high strength β-Ca(POィイD23ィエD2)ィイD22ィエD2 fibers (CPF) treated with dilune NaOH solution. PLA dissolved by using methylene chloride was mixed with the fibers. After drying the mixture, it was hot-pressed uniaxially under a pressure of 40 MPa at 180℃, resulting in fabrication of a PLA-composite containing CPF. Almost no degradation in the bending strength was observed even when a large amount of the fibers (【approximately equal】50 wt%) was introduced, and the modulus of elasticity was increased effectively with increasing the fiber content. The PLA-composite with modulus of elasticity of >5 GPa similar to that of natural bone was found to be prepared when the fiber content was over 35 wt%. The bending test of the composites showed that very high energy is consumed for their fracture and that the fracture proceeds ste … More p by step, even beyond the maximum stress.After the PLA sample was soaked in simulated body fluid (SBF) for 90 days, the maximum stress was decreased extremely and the specimen showed typical brittle fracture similar to that of conventional ceramics. Hardening originated from hydrolysis of PLA is supported to suppress degradation of the materials in modulus of elasticity, although the maximum stresses are decreased. The PLA-composite containing 35% CPF showed the characteristic fracture pattern even after the soaking for 90 days in control to that PLA. Hydrolysis of PLA induces serious degradation in the composite would be also converted into a brittic material by the soaking in SBF as well as the PLA sample without CPF. However, since CPF in the composite can share an applied load successfully, the material shows non-catastrophic fracture even after the soaking. Hybridization of CPF into PLA as a matrix phase has great advantages that modulus of elasticity is improved to the value close to that of natural bone and that degradation of the material in toughness in a wet environment is relatively restricted. The mechanical properties of the PLA composites are expected to meet the biomechanical requirements of some applications such as bone plates or temporary internal fixation of bones broken damaged. Less

采用生物可吸收聚左旋乳酸（PLA）和经过处理的高强度β-Ca（PO-D23-D2）D2纤维（CPF）制备了弹性模量接近天然骨的新型生物材料。将用二氯甲烷溶解的稀NaOH溶液与纤维混合，将混合物干燥后，在室温下进行单轴热压。在180℃、40 MPa的压力下，制备出含有CPF的PLA复合材料，即使引入大量纤维（【约等于】50 wt%），弯曲强度也几乎没有下降。随着纤维含量的增加，弹性模量得到有效提高，当纤维含量增加时，制备的PLA复合材料的弹性模量>5 GPa，与天然骨的弹性模量相似。复合材料的弯曲测试表明，其断裂消耗了非常高的能量，并且断裂逐步进行，甚至超出了最大应力。将PLA样品浸泡在模拟体液中后。 (SBF) 90 天，最大应力极大降低，并且样品表现出与传统陶瓷相似的典型脆性断裂，尽管如此，仍支持由 PLA 水解引起的硬化来抑制材料的弹性模量退化。即使在浸泡 90 天后，含有 35% CPF 的 PLA 复合材料仍显示出特征断裂模式，因为 PLA 的水解会导致复合材料严重降解，也会转化为脆质材料。然而，由于复合材料中的 CPF 可以成功地分担所施加的载荷，因此即使在 CPF 混合后，材料也会表现出非灾难性断裂。 PLA作为基体相具有很大的优点，弹性模量提高到接近天然骨的值，并且材料在潮湿环境中韧性的退化相对受到限制，因此PLA复合材料的机械性能有望得到改善。满足一些应用的生物力学要求，例如骨板或骨折损坏较少的临时内固定。

项目成果

T.Kasuga,et al.: "New Calcium Phosphate Glass-Ceramics Prepared by Crystallization and Sintering of Glass Pouders" Proceedings of 18th International Congress on Glass. E4. 31-36 (1998)

T.Kasuga等人：“通过玻璃粉结晶和烧结制备新型磷酸钙玻璃陶瓷”第18届国际玻璃大会论文集。

T.Kasuga,et al.: "Preparation of polylactic acid composites containing β-Ca(PO_3)_2 fibers"J.Mater.Res.. 14. 418-424 (1999)

T. Kasuga 等人：“含有 β-Ca(PO_3)_2 纤维的聚乳酸复合材料的制备”J. Mater. 14. 418-424 (1999)

Toshihiko Kasuga, Yoshio Ota, Masayuki Nogami, and Yoshihiro Abe: "Surface Modification of Calcium Metaphosphate Fibers"J. Mater. Sci. : Mater Med.. 11 (in press). (2000)

Toshihiko Kasuga、Yoshio Ota、Masayuki Nogami 和 Yoshihiro Abe：“偏磷酸钙纤维的表面改性”J。

T. Kasuga, 他: "Surface modification of calcium metaphosphate fibers"J. Mater. Sci. : Mater. Med.. 11(印刷中). (2000)

T. Kasuga 等人：“偏磷酸钙纤维的表面改性”J. Mater. ：Mater. 11（出版中）。

Toshihiko Kasuga, Yoshio Ota, Shin-ya Ozaki, Tomokatsu Hayakawa, Masayuki Nogami, and Yoshihiro Abe: "Mechanical Properties of Polylatic Acid Composites Containing β-Ca(POィイD23ィエD2)ィイD22ィエD2 Fibers"Phosphorus Res. Bull.. 10. 640-645 (1999)

Toshihiko Kasuga、Yoshio Ota、Shin-ya Ozaki、Tomokatsu Hayakawa、Masayuki Nogami 和 Yoshihiro Abe：“含有 β-Ca(POiiD23ieD2)iiD22ieD2 纤维的聚乳酸复合材料的机械性能”Phosphorus Res.. 10. 640-645 ( 1999）