Quantitative analysis of fundus autofluorescence based on an excitation wavelength of 532nm.

基于 532nm 激发波长的眼底自发荧光定量分析。

• 批准号: 23791996
• 负责人: KOJIMA Akira
• 金额: $ 1.91万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791996/
• 关键词: 臨床研究; 眼底自発蛍光; 加齢黄斑変性; 中心性漿液性脈絡網膜症; リポフスチン; キサントフィル

Fundus autofluorescence images based on an excitation wavelength of 532nm (532AF) were acquired using modified scanning laser ophthalmoscope: F-10 (NIDEK, Aichi, Japan). The findings of 532AF in normal eyes and pathologic eyes were analyzed. 1) In normal eyes, fluorescent brightness distribution of 532AF was similar to that of autofluorescence based on 490nm excitation light (490AF). As 532nm light is only slightly blocked by macular pigments, foveal autofluorescence was well observed by 532AF. 2) Abnormal findings of 532AF were observed in eyes with central serous chorioretinopathy. Hyper-532AF was observed in the area with serous retinal detachment (SRD) and resolved SRD where outer retina was damaged. Hypo-532AF was seen in the area with damaged retinal pigment epithelium. 3) Reference fluorescent tip was installed inside of the modified F-10 for quantitative analysis of 532AF. 532AF brightness of both fundus and reference tip were compared and analyzed. The data were under investigation now.

使用改进的扫描激光检眼镜 F-10（NIDEK，爱知县，日本）获取基于 532nm（532AF）激发波长的眼底自发荧光图像。分析了正常眼和病理眼中532AF的表现。 1) 在正常眼中，532AF 的荧光亮度分布与基于 490nm 激发光的自发荧光 (490AF) 相似。由于 532nm 光仅被黄斑色素轻微阻挡，因此 532AF 可以很好地观察到黄斑中心凹自发荧光。 2)在患有中心性浆液性脉络膜视网膜病变的眼睛中观察到532AF的异常表现。在浆液性视网膜脱离 (SRD) 区域观察到 Hyper-532AF，并在外层视网膜受损的地方解决了 SRD。 Hypo-532AF 在视网膜色素上皮受损的区域可见。 3) 将参比荧光吸头安装在改进的F-10内部，用于对532AF进行定量分析。对眼底和参考端的532AF亮度进行比较和分析。目前这些数据正在调查中。

项目成果

中心性漿液性脈絡網膜症の532nm眼底自発蛍光所見

中心性浆液性脉络膜视网膜病变的 532nm 眼底自发荧光表现

• 作者: 小島 彰;近藤剛史;丸子一朗;石龍鉄樹;飯田知弘
• 通讯作者: 飯田知弘

Fundus autofluorescence and optical coherence tomography findings in branch retinal vein occlusion

视网膜分支静脉阻塞的眼底自发荧光和光学相干断层扫描结果

• 发表时间: 2012
• 影响因子: 1.9
• 作者: Sekiryu T; Iida T; Sakai E; Maruko I; Ojima A; Sugano Y
• 通讯作者: Sugano Y

正常眼における532nm眼底自発蛍光の輝度分布

正常眼532nm眼底自发荧光亮度分布

• 作者: 小島 彰;菅野幸紀;伊勢重之;丸子一朗;石龍鉄樹;飯田知弘
• 通讯作者: 飯田知弘

Demographic features of idiopathic macular telangiectasia in Japanese patients

日本特发性黄斑毛细血管扩张症患者的人口统计学特征

• 发表时间: 2012
• 影响因子: 2.4
• 作者: Maruko I; Iida T; Sugano Y; Ojima A; Oyamada H; Sekiryu T
• 通讯作者: Sekiryu T

Photopigments in central serous chorioretinopathy

中心性浆液性脉络膜视网膜病变中的感光色素

• 发表时间: 2011
• 影响因子: 4.2
• 作者: Ojima A; Iida T; Sekiryu T; Maruko I; Sugano Y
• 通讯作者: Sugano Y