Effect of lifestyle and single nucleotide polymorphisms on breast cancer risk: A case-control study in Japanese women

生活方式和单核苷酸多态性对乳腺癌风险的影响：日本女性的病例对照研究

• 批准号: 22501058
• 负责人: DOIHARA Hiroyoshi
• 金额: $ 2.83万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22501058/
• 关键词: 乳癌; 遺伝子多型; エストロゲン受容体; リスク; 症例対象研究; 遺伝子型; ライフスタイル; 乳がん; リスクモデル; エストロゲン; 生活習慣; マンモグラフィ濃度; 症例対照研究; SNP解析

[Background] Lifestyle, including diet and physical activity, and birth/breastfeeding history are known to affectthe risk for breast cancer. A correlation between single nucleotide polymorphisms (SNPs) and breast cancer risk has also been suggested in some reports, but the gene-environment interaction with breast cancer risk has not been examined widely.[Methods] The subjects were 476 breast cancer patients and 528 controls who attended a health check and had no history of breast cancer. Lifestyle was examined using a questionnaire with 48 questions about diet, physical activity, smoking habits, alcohol intake, and birth/breastfeeding history, etc. Based on past reports, we analyzed 6 SNPs (TNRC9-rs3803662,LSP1/11q-rs3817198, MAP3K1-rs889312, 8q24-rs13281615, 5p12-rs981782, and TGFβ1-rs1800470) using blood samples, and calculated age-adjusted odds ratios in a multiple logistic regression analysis. [Results] The study was performed from December 2010 to November 2011. Lifestyle factors … More (age-adjusted odds ratio, [95% confident interval]) found to have a significant correlation with development of breast cancer included BMI (1.041, [1.00 - 1.08]), smoking history (2.28, [1.45 - 3.65]), small number of births (1.18, [1.05 - 1.34]), no exercise during leisure time (1.36, [1.06 - 1.77]), low intake of green and yellow vegetables (1.69, [1.01 - 2.85]), and low intake of mushrooms (1.58, [1.05 - 2.39]). Stratified analysis based on menopause status showed that smoking history (1.85, [1.00 - 3.49]) and low intake of green and yellow vegetables (2.5, [1.03 - 5.88]) were significant risk factors before menopause, and that smoking history (2.28, [1.45 - 3.65]),low intake of green and yellow vegetables (2.24, [1.09 - 4.68]), no exercise during leisure time (1.67, [1.19 - 2.36]), small number of births (1.49, [1.25 - 1.78]), and no breastfeeding history (1.03, [1.01 - 1.06]) were significant risk factors after menopause. The results of SNP analysis suggested that TNRC9-rs3803662 was a significant risk factor in women before menopause (2.29, [1.25 - 4.25]). However, in multivariate analysis including lifestyle factors and SNPs, only smoking history emerged as a significant risk factor in women before menopause. [Conclusion] A correlation between lifestyle and breast cancer risk was found in this study, consistent with previous findings. Lifestyle and environmental factors such as births and breastfeeding may be more important than SNPs as risk factors for breast cancer. Less

[背景] 生活方式，包括饮食和体力活动以及出生/母乳喂养史已知会影响乳腺癌风险，一些报告也提出了单核苷酸多态性 (SNP) 与乳腺癌风险之间的相关性，但该基因。 - 环境与乳腺癌风险的相互作用尚未得到广泛研究。[方法] 采用问卷调查的方式对参加健康检查且无乳腺癌病史的 476 名乳腺癌患者和 528 名对照者进行了调查。共 48 个问题，涉及饮食、体力活动、吸烟习惯、饮酒、出生/母乳喂养史等。根据以往的报告，我们分析了 6 个 SNP（TNRC9-rs3803662、LSP1/11q-rs3817198、MAP3K1-rs889312、8q24-rs13281615） 、5p12-rs981782、以及TGFβ1-rs1800470）使用血液样本，并在多元逻辑回归分析中计算年龄调整优势比。[结果]该研究于 2010 年 12 月至 2011 年 11 月进行。生活方式因素……更多（年龄调整优势比，[95%]。置信区间]）发现与乳腺癌的发展有显着相关性，包括BMI（1.041，[1.00 - 1.08]）、吸烟病史 (2.28, [1.45 - 3.65])、出生次数少 (1.18, [1.05 - 1.34])、闲暇时间不运动 (1.36, [1.06 - 1.77])、绿色和黄色蔬菜摄入量低 (1.69, [1.01 - 2.85]），蘑菇摄入量低（1.58，[1.05 - 2.39]）基于绝经状态的分层分析显示吸烟史（1.85，[1.00 - 3.49]）和绿色和黄色蔬菜摄入量低（2.5，[1.03 - 5.88]）是绝经前的显着危险因素。历史（2.28，[1.45 - 3.65]），绿色和黄色蔬菜摄入量低（2.24，[1.09 - 4.68]）、闲暇时间不运动（1.67，[1.19 - 2.36]）、出生次数少（1.49，[1.25 - 1.78]）和没有母乳喂养史（1.03，[1.01 - 1.06]）是显着风险SNP分析结果提示TNRC9-rs3803662是绝经后的重要危险因素。绝经前女性 (2.29, [1.25 - 4.25]) 然而，在包括生活方式因素和 SNP 在内的多变量分析中，只有吸烟史是绝经前女性的显着危险因素 [结论] 生活方式与乳腺癌风险之间存在相关性。这项研究发现，生活方式和环境因素（如出生和母乳喂养）可能比 SNP 更重要，是乳腺癌的危险因素。

项目成果

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乳癌リスク関連遺伝子多型,ESR1/6q25.1-rs2046210 と乳腺濃度との関連性解析

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• 发表时间: 2013
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