The elucidation of molecular basis of the diversity and transmissibility in abnormal prion protein formation
阐明异常朊病毒蛋白形成的多样性和传播性的分子基础
基本信息
- 批准号：15H04269
- 负责人：
- 金额：$ 9.24万
- 依托单位：
- 依托单位国家：日本
- 项目类别：Grant-in-Aid for Scientific Research (B)
- 财政年份：2015
- 资助国家：日本
- 起止时间：2015-04-01 至 2019-03-31
- 项目状态：已结题
- 来源：
- 关键词：
项目摘要
暂无数据
项目成果
期刊论文数量（0）
专著数量（0）
科研奖励数量（0）
会议论文数量（0）
专利数量（0）
"Wire-QuIC": a new detection sysmte of human prion
“Wire-QuIC”：一种新型人类朊病毒检测系统
- DOI：
- 发表时间：2016
- 期刊：
- 影响因子：0
- 作者：Mori T;Atarashi R;Takatsuki H;Satoh K;Nakagaki T;Ishibashi D; Nishida N.
- 通讯作者：Nishida N.
Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases.
- DOI：10.1371/journal.pone.0126930
- 发表时间：2015
- 期刊：
- 影响因子：3.7
- 作者：Takatsuki H;Satoh K;Sano K;Fuse T;Nakagaki T;Mori T;Ishibashi D;Mihara B;Takao M;Iwasaki Y;Yoshida M;Atarashi R;Nishida N
- 通讯作者：Nishida N
Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients.
- DOI：10.1016/j.ebiom.2016.08.033
- 发表时间：2016-10
- 期刊：
- 影响因子：11.1
- 作者：Takatsuki, Hanae;Fuse, Takayuki;Nakagaki, Takehiro;Mori, Tsuyoshi;Mihara, Ban;Takao, Masaki;Iwasaki, Yasushi;Yoshida, Mari;Murayama, Shigeo;Atarashi, Ryuichiro;Nishida, Noriyuki;Satoh, Katsuya
- 通讯作者：Satoh, Katsuya
Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells.
- DOI：10.1371/journal.pone.0137958
- 发表时间：2015
- 期刊：
- 影响因子：3.7
- 作者：Ishibashi D;Homma T;Nakagaki T;Fuse T;Sano K;Takatsuki H;Atarashi R;Nishida N
- 通讯作者：Nishida N
Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits.
- DOI：10.1038/srep18440
- 发表时间：2015-12-16
- 期刊：
- 影响因子：4.6
- 作者：Fuchigami T;Yamashita Y;Kawasaki M;Ogawa A;Haratake M;Atarashi R;Sano K;Nakagaki T;Ubagai K;Ono M;Yoshida S;Nishida N;Nakayama M
- 通讯作者：Nakayama M
共 13 条
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Atarashi Ryuichiro其他文献
パーキンソン病（２）αシヌクレイン
帕金森病 (2) α-突触核蛋白
- DOI：
- 发表时间：20182018
- 期刊：
- 影响因子：0
- 作者：Matsubara Takehiro;Satoh Katsuya;Homma Takujiro;Nakagaki Takehiro;Yamaguchi Naohiro;Atarashi Ryuichiro;Sudo Yuka;Uezono Yasuhito;Ishibashi Daisuke;Nishida Noriyuki;上村紀仁Matsubara Takehiro;Satoh Katsuya;Homma Takujiro;Nakagaki Takehiro;Yamaguchi Naohiro;Atarashi Ryuichiro;Sudo Yuka;Uezono Yasuhito;Ishibashi Daisuke;Nishida Noriyuki;上村紀仁
- 通讯作者：上村紀仁上村紀仁
Development of Radioiodinated Benzofuran Derivatives for in Vivo Imaging of Prion Deposits in the Brain
开发放射性碘化苯并呋喃衍生物，用于大脑中朊病毒沉积物的体内成像
- DOI：10.1021/acsinfecdis.8b0018410.1021/acsinfecdis.8b00184
- 发表时间：20192019
- 期刊：
- 影响因子：5.3
- 作者：Fuchigami Takeshi;Kawasaki Masao;Koyama Ryusuke;Nakaie Mari;Nakagaki Takehiro;Sano Kazunori;Atarashi Ryuichiro;Yoshida Sakura;Haratake Mamoru;Ono Masahiro;Nishida Noriyuki;Nakayama MorioFuchigami Takeshi;Kawasaki Masao;Koyama Ryusuke;Nakaie Mari;Nakagaki Takehiro;Sano Kazunori;Atarashi Ryuichiro;Yoshida Sakura;Haratake Mamoru;Ono Masahiro;Nishida Noriyuki;Nakayama Morio
- 通讯作者：Nakayama MorioNakayama Morio
Discrimination between L-type and C-type bovine spongiform encephalopathy by the strain-specific reactions of real-time quaking-induced conversion
通过实时震动诱导转换的菌株特异性反应区分 L 型和 C 型牛海绵状脑病
- DOI：10.1016/j.bbrc.2020.03.18310.1016/j.bbrc.2020.03.183
- 发表时间：20202020
- 期刊：
- 影响因子：3.1
- 作者：Ubagai Kaori;Fukuda Shigeo;Mori Tsuyoshi;Takatsuki Hanae;Taguchi Yuzuru;Kageyama Soichi;Nishida Noriyuki;Atarashi RyuichiroUbagai Kaori;Fukuda Shigeo;Mori Tsuyoshi;Takatsuki Hanae;Taguchi Yuzuru;Kageyama Soichi;Nishida Noriyuki;Atarashi Ryuichiro
- 通讯作者：Atarashi RyuichiroAtarashi Ryuichiro
Prion protein interacts with the metabotropic glutamate receptor 1 and regulates the organization of Ca2+ signaling
朊病毒蛋白与代谢型谷氨酸受体 1 相互作用并调节 Ca2 信号传导的组织
- DOI：10.1016/j.bbrc.2020.02.10210.1016/j.bbrc.2020.02.102
- 发表时间：20202020
- 期刊：
- 影响因子：3.1
- 作者：Matsubara Takehiro;Satoh Katsuya;Homma Takujiro;Nakagaki Takehiro;Yamaguchi Naohiro;Atarashi Ryuichiro;Sudo Yuka;Uezono Yasuhito;Ishibashi Daisuke;Nishida NoriyukiMatsubara Takehiro;Satoh Katsuya;Homma Takujiro;Nakagaki Takehiro;Yamaguchi Naohiro;Atarashi Ryuichiro;Sudo Yuka;Uezono Yasuhito;Ishibashi Daisuke;Nishida Noriyuki
- 通讯作者：Nishida NoriyukiNishida Noriyuki
共 4 条
- 1
Atarashi Ryuichiro的其他基金
Elucidation of the amplification mechanism using cultured human prion persistent infection cells and development of novel prevention and treatment for prion diseases
利用培养的人朊病毒持续感染细胞阐明扩增机制并开发新型朊病毒疾病预防和治疗方法
- 批准号：18H0272118H02721
- 财政年份：2018
- 资助金额：$ 9.24万$ 9.24万
- 项目类别：Grant-in-Aid for Scientific Research (B)Grant-in-Aid for Scientific Research (B)
相似海外基金
Elucidation of the amplification mechanism using cultured human prion persistent infection cells and development of novel prevention and treatment for prion diseases
利用培养的人朊病毒持续感染细胞阐明扩增机制并开发新型朊病毒疾病预防和治疗方法
- 批准号：18H0272118H02721
- 财政年份：2018
- 资助金额：$ 9.24万$ 9.24万
- 项目类别：Grant-in-Aid for Scientific Research (B)Grant-in-Aid for Scientific Research (B)
Molecular design of quadruplex-forming nculeic acids that inhibit the pathological conformational conversion of PrP and elucidation of its inhibitory mechanism
抑制PrP病理构象转变的四链体核酸的分子设计及其抑制机制的阐明
- 批准号：16K0726916K07269
- 财政年份：2016
- 资助金额：$ 9.24万$ 9.24万
- 项目类别：Grant-in-Aid for Scientific Research (C)Grant-in-Aid for Scientific Research (C)
Sensitive detection of abnormal prion protein in genetic human prion diseases
人类遗传性朊病毒病中异常朊病毒蛋白的灵敏检测
- 批准号：2330012723300127
- 财政年份：2011
- 资助金额：$ 9.24万$ 9.24万
- 项目类别：Grant-in-Aid for Scientific Research (B)Grant-in-Aid for Scientific Research (B)
Analysis of interaction between novel prion protein (PrP) family Shadoo and PrP
新型朊病毒蛋白 (PrP) 家族 Shadoo 与 PrP 之间的相互作用分析
- 批准号：2378029923780299
- 财政年份：2011
- 资助金额：$ 9.24万$ 9.24万
- 项目类别：Grant-in-Aid for Young Scientists (B)Grant-in-Aid for Young Scientists (B)
A possible mechanism for PrP^<Sc> formation through modification with a lipid peroxidation product hydroxylnonenal at the membrane interface
通过在膜界面处用脂质过氧化产物羟基壬烯醛进行修饰，形成 PrP^<Sc> 的可能机制
- 批准号：2265809522658095
- 财政年份：2010
- 资助金额：$ 9.24万$ 9.24万
- 项目类别：Grant-in-Aid for Challenging Exploratory ResearchGrant-in-Aid for Challenging Exploratory Research