System Analysis of Sympathetic Regulation of Heart Failure and Exploration of New Bionic Autonomic Neuromodulation Therapy

心力衰竭交感神经调节的系统分析及新型仿生自主神经调节疗法的探索

• 批准号: 23700550
• 负责人: SATA Yusuke
• 金额: $ 2.66万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700550/
• 关键词: 生体制御; システム生理; 心不全; 高血圧; 自律神経; 自律神経治療; 腎臓交感神経; 国際情報交流

To elucidate the mechanisms of sympathetic regulation in heart failure, we examined sympathetic nervous activity and blood pressure in response to change in isolated carotid sinus pressure in spontaneously hypertensive rats (SHR), as hypertension is considered the major cause of heart failure. The neural arc, the sympathetic nerve activity in response to carotid sinus pressure, shifted towards a higher set point whereas the peripheral arc, the pressor response to sympathetic nerve activity, did not change when compared with normotensive Wistar Kyoto Rats (WKY). Renal sympathetic nerve denervation in SHR reduced blood pressure not only through baroreflex regulation, but also baroreflex-independently by shifting the neural arc towards a lower set point. The antihypertensive effects of renal denervation did not completely normalize either blood pressure or sympathetic nervous activity to the levels seen in WKY. As a conclusion, the neuromodulation therapy, renal denervation, reduced sympathetic nervous activity, and, through the baroreflex regulation of sympathetic nervous activity, decreased blood pressure in renal denervated SHR compared to SHR.

为了阐明心力衰竭中交感神经调节的机制，我们检查了交感神经活动和血压对自发性高血压大鼠（SHR）孤立颈动脉窦压力变化的反应，因为高血压被认为是心力衰竭的主要原因。与血压正常的 Wistar 京都大鼠 (WKY) 相比，神经弧（交感神经活动对颈动脉窦压力的反应）向更高的设定点移动，而外周弧（对交感神经活动的升压反应）没有变化。 SHR 中的肾交感神经去神经不仅通过压力反射调节来降低血压，而且还通过将神经弧移向较低的设定点来独立于压力反射。肾去神经支配的抗高血压作用并未使血压或交感神经活动完全正常化至 WKY 中所见的水平。总之，与 SHR 相比，神经调节治疗、肾去神经支配、交感神经活动减少，以及通过交感神经活动的压力感受反射调节，肾去神经支配的 SHR 的血压降低。

项目成果

A Novel Framework to Assess Neural and Peripheral Characteristics in Hypertension using Baroreflex Equilibrium Diagram

使用 Baroreflex 平衡图评估高血压神经和外周特征的新框架

• 发表时间: 2011
• 作者: Yuki Akagi;et al.;Yusuke Sata
• 通讯作者: Yusuke Sata

Sympatho-modulation by Renal Denervation in Spontaneously Hypertensive Rats

自发性高血压大鼠肾去神经支配的交感神经调节

• 发表时间: 2013
• 作者: Kawada T;Akiyama T;Shimizu S;Sata Y;Turner MJ;Shirai M and Sugimachi M;佐田悠輔;Yusuke Sata;佐田悠輔;佐田悠輔;佐田悠輔
• 通讯作者: 佐田悠輔

Central vagal activation by alpha2-adrenergic stimulation is impaired in spontaneously hypertensive rats

自发性高血压大鼠中α2-肾上腺素能刺激的中枢迷走神经激活受损

• DOI: 10.1111/j.1748-1716.2012.02439.x
• 发表时间: 2012
• 期刊: Acta Physiol (Oxf)
• 作者: Kawada T;Akiyama T;Shimizu S;Kamiya A;Uemura K;et al
• 通讯作者: et al

Exercise-Induced ST Elevation in Patients With Non-Ischemic Dilated Cardiomyopathy and Narrow QRS Complexes

非缺血性扩张型心肌病和窄 QRS 波群患者运动引起的 ST 段抬高

• DOI: 10.1253/circj.cj-12-0814
• 发表时间: 2013
• 期刊: Circulation Journal
• 影响因子: 3.3
• 作者: S. Iwashita;Y. Hiramatsu;T. Otani;C. Amano;M. Hirai;H. Minematsu;H. Kitagawa;K. Oie;E. Yuba;K. Kono;M. Miyamoto;K. Igarashi;Hiroyuki Takahama
• 通讯作者: Hiroyuki Takahama

Centrally Mediated Anti-hypertensive Effects of Renal Denervation in Spontaneously Hypertensive Rats

去肾神经对自发性高血压大鼠的中枢介导的抗高血压作用

• 发表时间: 2013
• 作者: T. Ito;Y. Koyama;M. Otsuka;E. Yuba;Yusuke Sata
• 通讯作者: Yusuke Sata