Role of host proton-sensing receptors in tumorigenesis: analysis with receptor-deficient mice

宿主质子敏感受体在肿瘤发生中的作用：受体缺陷小鼠的分析

• 批准号: 23659029
• 负责人: OKAJIMA Fumikazu
• 金额: $ 2.41万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659029/
• 关键词: プロトン感知性受容体; TDAG8; 細胞外 pH; 腫瘍; マクロファージ; プロトン受容体; がん

It is well known that tumorigenesis is accompanied by extracellular acidification. However, the role of acidification remains unknown. Here, we investigated the role of recently identified proton-sensing receptors by using their receptor-deficient mice. Our results suggested that proton-sensing receptors are involved in tumorigenesis andextracellular acidification changes the M1-M2 macrophage phenotype.

众所周知，肿瘤发生伴随着细胞外酸化。但是，酸化的作用仍然未知。在这里，我们通过使用其受体缺陷型小鼠研究了最近鉴定出的质子感应受体的作用。我们的结果表明，质子感应受体参与肿瘤发生和细胞酸化会改变M1-M2巨噬细胞表型。

项目成果

プロトンはマウス肥満細胞からのサイトカイン産生を調節する

质子调节小鼠肥大细胞的细胞因子产生

• 发表时间: 2013
• 作者: 上出庸介;石塚 全;ほか
• 通讯作者: ほか

Constitutively active heat shock factor 1 enhances glucose-driven insulinsecretion

组成型活性热休克因子 1 增强葡萄糖驱动的胰岛素分泌

• 发表时间: 2011
• 期刊: Metabolism
• 影响因子: 9.8
• 作者: Uchiyama T;Tomono S;Utsugi T;Ohyama Y;Nakamura T;Tomura H;Kawazu S;Okajima F;and Kurabayashi M.
• 通讯作者: and Kurabayashi M.

Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells

• DOI: 10.1016/j.bbrc.2011.08.087
• 发表时间: 2011-10-07
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Matsuzaki, Shinichi;Ishizuka, Tamotsu;Okajima, Fumikazu
• 通讯作者: Okajima, Fumikazu

Unmasking of LPA(1)receptor-mediated migration response to lysophosphatidic acid by interleukin-1β-induced attenuation of Rho signaling pathways in rat astrocytes

通过白介素-1β诱导的大鼠星形胶质细胞中 Rho 信号通路的减弱，揭示 LPA(1) 受体介导的对溶血磷脂酸的迁移反应

• DOI: 10.1111/j.1471-4159.2011.07188.x
• 发表时间: 2011
• 期刊: J Neurochem
• 影响因子: 4.7
• 作者: Kitamura H;Makide K;Shuto A;Ikubo M;Inoue A;Suzuki K;Sato Y;Nakamura S;Otani Y;Ohwada T;Aoki J;Kazushi Mashima;Shiro Saka;竹内洋文;Sato K
• 通讯作者: Sato K

Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages

• DOI: 10.1016/j.bbrc.2011.10.122
• 发表时间: 2011-12-02
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: He, Xiao-dong;Tobo, Masayuki;Okajima, Fumikazu
• 通讯作者: Okajima, Fumikazu