Regulatory mechanism of signal transduction involved in cytokine production from basophils and the control of type 2 immune response.

信号转导的调节机制涉及嗜碱性粒细胞产生细胞因子和控制 2 型免疫反应。

• 批准号: 23790438
• 负责人: SANJO Hideki
• 金额: $ 2.75万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790438/
• 关键词: 好塩基球伝達; サイトカイン; シグナル; 好塩基球; シグナル伝達

The aim of this study is to reveal the unknown molecular mechanisms of signaling pathway that regulate activation of basophils, important for type 2 immune response, as well as cytokine production.As a result the regulatory mechanisms were evident that the resting basophils restrain the signal transduction via FcεRI, a receptor for IgE, by negatively regulating the protein levels of signaling molecules and Bcl6, known as transcriptional corepressornegatively regulates cytokine production induced by FcεRI crosslinking in the resting basophils.

The aim of this study is to reveal the unknown molecular mechanisms of signaling pathway that regulate activation of basophils, important for type 2 immunoresponse, as well as cytokine production.As a result of the regulatory mechanisms were evidence that the resting basophils restrain the signal transduction via FcεRI, a receptor for IgE, by negatively regulating the protein levels of signaling molecules and Bcl6, known as转录核心寄生能调节静息嗜碱性粒细胞中FcεRI交联引起的细胞因子产生。

项目成果

IL-15-independent generation of memory-like' innate' CD8+ T cells in IRF-2-deficient mice

IRF-2缺陷小鼠中不依赖IL-15产生记忆样“先天”CD8 T细胞

• 发表时间: 2011
• 作者: T. Notake;A. Oda;H. Sanjo;S. Hida;S. Taki
• 通讯作者: S. Taki

Differential Requirements for IRF-2 in Generation of CD1d-Independent T Cells Bearing NK Cell Receptors

• DOI: 10.4049/jimmunol.1200210
• 发表时间: 2012-05-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Notake, Tsuyoshi;Horisawa, Shin;Taki, Shinsuke
• 通讯作者: Taki, Shinsuke

Essential roles of Tab2 and Tab3 in the activation of MAPK but not NF-kB, in B cells.

Tab2 和 Tab3 在 B 细胞中 MAPK（而非 NF-kB）激活中发挥重要作用。

• 发表时间: 2012
• 作者: Ori D.;Kato H.;Sanjo H.;Akira S.;Takeuchi O.
• 通讯作者: Takeuchi O.

IL-3-induced IL-13 production by basophils but not mast cells was sensitive to Paired immunoglobulin-like receptor (PIR)-B mediated inhibitory signals

IL-3 诱导的嗜碱性粒细胞而非肥大细胞产生 IL-13 对配对免疫球蛋白样受体 (PIR)-B 介导的抑制信号敏感

• 发表时间: 2011
• 作者: Akihisa Oda;ほか
• 通讯作者: ほか

Paxillin wasrequired for IL-3-induced IL-4 production in basophils.

IL-3 诱导嗜碱性粒细胞产生 IL-4 需要桩蛋白。

• 发表时间: 2012
• 作者: Hasegawa A.;Hida S.;Sanjo H.;Oda A.;Taki S.;Taniguchi S.
• 通讯作者: Taniguchi S.