The relation of leg venous function and structure to orthostatic hypotension in humans

腿部静脉功能和结构与人体直立性低血压的关系

• 批准号: 18500554
• 负责人: MIURA Akira
• 金额: $ 2.41万
• 依托单位: Prefectural University of Hiroshima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500554/
• 关键词: orthostatic hypotension; venous compliance; capillary filtration; endurance training; 起立耐性; 下腿静脈コンプライアンス; 膝窩静脈コンプライアンス; 静脈血管収縮

BACKGROUND AND PURPOSE: Despite extensive investigation, the effects of either cardiovascular fitness or age on orthostatic remain uncertain. Calf venous compliance may be a critical factor in determining the cardiovascular stress associated with change in orthostasis. Preventing fluid shifts into the legs markedly reduces reflex responses to an orthostatic stressor. The extent to which exercise training in a previously sedentary older and young population will affect venous compliance and tolerance to the orthostatic stress is unknown. An evaluation of the compliance of the whole venous system (including venule to large vein) in human calf was developed with a venous congested plethysmography (VCPG) (Halliwill, et al., J.Appl.Physiol. 1999) which has already been used in several application studies. Utilizing the B-mode ultrasonography (US), we have proposed a similar technique for estimating the compliance in medium venous vessels (i.e., Popliteal vein) using US images, which is deri … More ved from the CSA-venous pressure (Pv) relationship.Therefore, we investigate:1. The relation of leg venous compliance to orthostatic intolerance in humans.2. Effect of 10days successive endurance training on leg venous compliance.Secondly, to clearly define the venous vascular function concerning venous pooling, we examined:3. The effect of ischemic handgrip exercise on leg venous compliance in humans4. The relationship between venous compliance and capillary filtration in the lower limb.RESULT: Venous compliance was not different between tolerance and intolerance group. This result suggested that the leg venous compliance is not dominant determinant of the orthostatic intolerance in humans. Venous pooling decreases cardiac filling pressure and blood pressure (BP); therefore, arterial baroreceptors (carotid and aortic) and baroreceptors in the cardiopulmonary region must adapt to maintain BP over a fairly wide range of hemodynamic conditions. And no change in calf venous compliance was found after 10 days successive of endurance training (60 min, 40% peak Vo2). Under the sympathetic stimulation (sympatho-excitatory stimulation) induced by the ischemic handgrip exercise to fatigue followed post-exercise ischemia. Compared to the control, the calf volume was consistently smaller under the sympathetic stimulation. The venous compliance at lower Pv was significantly lower. These data shows to existence of sympathetic venous vascular regulation in humans. In addition, there is negative correlation was observed between venous compliance and capillary filtration in the lower limb. Less

背景和目的：尽管进行了广泛的研究，但心血管健康或年龄对直立性的影响仍然不确定，这可能是确定与直立性变化相关的心血管应激的关键因素。以前久坐的老年人和年轻人的运动训练会在多大程度上影响静脉顺应性和对直立性应激的耐受性尚不清楚。人类小腿静脉系统（包括小静脉到大静脉）是通过静脉充血体积描记法 (VCPG) 开发的（Halliwill 等人，J.Appl.Physiol. 1999），该技术已在多项应用研究中使用。 -模式超声检查（US），我们提出了一种类似的技术，用于使用 US 估计中等静脉血管（即腘静脉）的顺应性图像，源自 CSA-静脉压 (Pv) 关系。因此，我们研究：1. 腿部静脉顺应性与人体直立不耐受的关系。2. 连续 10 天耐力训练对腿部静脉顺应性的影响其次，为了清楚地定义与静脉池有关的静脉血管功能，我们检查了：3.缺血性握力训练对人体腿部静脉顺应性的影响4。下肢静脉顺应性和毛细血管滤过之间的关系。结果：耐受组和不耐受组之间的静脉顺应性没有差异。这一结果表明，腿部静脉顺应性并不是人类体位不耐受的主要决定因素。和血压 (BP)；因此，动脉压力感受器（颈动脉和主动脉）和心肺区域的压力感受器必须适应在相当宽的范围内维持血压。连续 10 天的耐力训练（60 分钟，40% 峰值 Vo2）后，在缺血性握力练习引起的交感神经刺激（交感神经兴奋性刺激）下，发现小腿静脉顺应性没有变化。与对照组相比，在交感神经刺激下，小腿体积始终较小。这些数据表明交感神经的存在。此外，在人体中观察到静脉顺应性与毛细血管滤过之间存在负相关性。

项目成果

Thigh muscle activation distribution and pulmonary Vo2 kinetics during mod crate,heavy,and very heavy cycling exercise in humans

人类现代板条箱、重型和超重型自行车运动期间大腿肌肉激活分布和肺 Vo2 动力学

• 发表时间: 2007
• 作者: Masako Endo; Mayumi Kobayakawa; Ryuta Kinugasa; Shinya kuno; Hiroshi Akima; Harry B.Rossiter; Akira Miura; Yoshiwki Fukuba
• 通讯作者: Yoshiwki Fukuba

起立性定血圧に対する下肢静脈伸展性の関与

下肢静脉扩张与立位血压的关系

• 发表时间: 2007
• 作者: 三浦 朗; 梶原 尚子; 大平 祐季; 江藤 幸; 山岡 雅子; 福場 良之
• 通讯作者: 福場 良之

Thigh muscle activation distribution and pulmonary Vo2 kinetics during moderate, heavy, and very heavy cycling exercise in humans

人类中度、重度和极重度自行车运动期间大腿肌肉激活分布和肺 Vo2 动力学

• 发表时间: 2007
• 作者: Masako; Endo; Mayumi; Kobayakawa; Ryuta; Kinugasa; Shinya; kuno; Hiroshi; Akima; Harry B.; Rossiter; Akira; Miura; Yoshivuki; Fukuba
• 通讯作者: Fukuba

Measurement of popliteal venous compliance with an ultrasonography

超声检查测量腘静脉顺应性

• 发表时间: 2006
• 作者: A Miura; A Tsumura; M Ide; M Urabe; H Ueoka; M Endo;Y Fukuba
• 通讯作者: Y Fukuba

Effects of femoral Vascular occlusion on ventilatory responses during recovery from exercise in human

股动脉血管闭塞对人体运动恢复期间通气反应的影响

• 发表时间: 2007
• 作者: Yoshiyuki; Fukuba; Asami; Kitano; Naoyuki; hayashi; Takayoshi; Yoshida; Hatumi; Ueoka; Masako; Yamaoka; Endo; Akira; Miura
• 通讯作者: Miura