Association between donor specific HLA antibodies and rejection in liver transplantation

供者特异性 HLA 抗体与肝移植排斥反应之间的关联

• 批准号: 23791520
• 负责人: WAKI Kayo
• 金额: $ 2.75万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791520/
• 关键词: 移植; 肝移植; 抗HLA抗体; 拒絶反応; 免疫抑制剤; 移植免疫; 移植予後

The role of human leukocyte antigen (HLA) antibodies in graft rejection after liver transplantation remains inconclusive. In order to investigate whether the presence of HLA antibodies was associated with rejection, we retrospectively examined the prevalence of anti-HLA antibodies in living-donor liver transplant recipients both before and after transplantation, and then analyzed the relationship of those antibodies with rejection.The prevalence of post-transplant HLA antibodies-especially donor-specific antibodies-in patients who experienced acute rejection was higher than in patients who had no rejection, though the difference did not reach statistical significance. In addition, the prevalence of antibodies before and after transplantation in patients who developed operational tolerance after withdrawal from immunosuppression was more likely to be negative than in patients who did not develop operational tolerance. Pre-transplant, the recipients who did not develop operational tolerance tended to have antibodies whose titers were already high. The highest mean fluorescence intensity of antibodies was significantly higher in patients who did not develop operational tolerance than in patients who developed operational tolerance. Therefore, not only the prevalence of antibodies but also their titers were closely associated with rejection.In our study, post-transplantation HLA antibodies were clearly associated with rejection.

人白细胞抗原（HLA）抗体在肝移植后移植排斥反应中的作用尚无定论。为了调查HLA抗体的存在是否与排斥相关，我们回顾性地检查了在活肝移植前和之后的活肝移植受者中抗HLA抗体的普遍性尽管差异没有达到统计学意义，但高于没有排斥的患者。此外，与未发展手术耐受性的患者相比，从免疫抑制退出后出现手术耐受性的患者的抗体患病率更可能为阴性。前移植前，没有发展操作耐受性的接收者往往具有滴度已经很高的抗体。在没有发展手术耐受性的患者中，抗体的最高平均荧光强度明显高于发展耐受性的患者。因此，不仅抗体的流行率，而且它们的滴度与排斥相关。在我们的研究中，移植后HLA抗体显然与排斥相关。

项目成果

Association of preformed anti-HLA antibody with operational tolerance in pediatric living-donor liver transplantation: a possible evidence of humoral sensitization (oral presentation)

预先形成的抗 HLA 抗体与儿科活体肝移植操作耐受性的关联：体液致敏的可能证据（口头陈述）

• 发表时间: 2012
• 作者: Kayo Waki;Yasuhiko Sugawara;Kouichi Mizuta;Masaru Hirata;Junichi Kaneko;Takashi Kadowaki;Taku Aoki;Kiyoshi Hasegawa;Norihiro Kokudo;Paul I. Terasaki
• 通讯作者: Paul I. Terasaki

Association of preformed anti-HLA antibody with operational tolerance in pediatric living-donor liver transplantation: a possible evidence of humoralsensitization (oral presentation)

儿科活体肝移植中预制抗 HLA 抗体与操作耐受性的关联：体液致敏的可能证据（口头报告）

• 作者: Kayo Waki;Yasuhiko Sugawara;Kouichi Mizuta;Masaru Hirata;Junichi Kaneko;Takashi Kadowaki;Taku Aoki;Kiyoshi Hasegawa;Norihiro Kokudo;Paul I. Terasaki
• 通讯作者: Paul I. Terasaki

Predicting operational tolerance in pediatric living-donor liver transplantation by absence of HLA antibodies

通过缺乏 HLA 抗体预测儿科活体肝移植的手术耐受性

• 发表时间: 2013
• 期刊: Transplantation
• 影响因子: 6.2
• 作者: Waki K;Sugawara Y;Mizuta K;Taniguchi M;Ozawa M;Hirata M;Nozawa M;Kaneko J;Takahashi K;Kadowaki T;Terasaki PI;Kokudo N
• 通讯作者: Kokudo N

1996-2011: the impact of HLA matching and a positive crossmatch on long-term survival and tolerance.

1996-2011：HLA 匹配和正交叉配对长期生存和耐受性的影响。

• 发表时间: 2011
• 作者: Kadowaki T;Kokudo N
• 通讯作者: Kokudo N