System Biology Model for Tumor Radiotherapy

肿瘤放射治疗的系统生物学模型

• 批准号: 23656170
• 负责人: TADANO Shigeru
• 金额: $ 2.41万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23656170/
• 关键词: バイオメカニクス; システムバイオロジー; 力学アナロジー; 放射線治療モデル; シミュレーション

This study is to propose a computational simulation method to calculate therapeuticoutcomes in radiotherapy, and also applied a method of system biology. As a tumor shrinksdue to radiation exposure, it was possible to express the radiotherapeutic effects in terms oftumor volume changes and geometric distortion. The shrinking was assumed to expressmechanical analogy of solid body. The relationships between radiation energy and tumordeformation were estimated from solid mechanics equations. Finite element models oftumors were constructed based on computed tomography (CT) images. Some values ofparameters prescribing tumor radiosensitivity or growth rates of tumor cells wereidentified so that the calculated results fit the clinical results. Simulation results will showthat the simulation model can be applied to a variety of clinical cases by determining thetumor parameters appropriately.

本研究提出了一种计算模拟方法来计算放射治疗的治疗结果，并应用了系统生物学的方法。当肿瘤因辐射暴露而缩小时，可以用肿瘤体积变化和几何变形来表达放射治疗效果。假设收缩表达了固体的力学类比。从固体力学方程估计辐射能量和肿瘤变形之间的关系。基于计算机断层扫描（CT）图像构建肿瘤的有限元模型。确定了一些规定肿瘤放射敏感性或肿瘤细胞生长速率的参数值，以便计算结果符合临床结果。仿真结果表明，通过适当确定肿瘤参数，仿真模型可以应用于多种临床病例。

项目成果

Computer Simulation and Analysis of Three-Dimensional Tumor Geometry in Radiotherapy

放射治疗中三维肿瘤几何形状的计算机模拟与分析

• 发表时间: 2013
• 作者: S. Takao;S. Tadano;H. Taguchi;H.Shirato
• 通讯作者: H.Shirato