The interaction between audiovisual environment and brain: normal development and autism spectrum disorders

视听环境与大脑的相互作用：正常发育与自闭症谱系障碍

• 批准号: 23601010
• 负责人: YAMASAKI TAKAO
• 金额: $ 3.41万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23601010/
• 关键词: 自閉症スペクトラム; 視聴覚認知; 事象関連電位; 光トポグラフィー; 視聴覚環境; 音声・言語認知; 顔認知; 視聴覚相互作用; optic flow

The hallmark feature of autism spectrum disorders (ASD) is impaired social interaction. It is possible that atypical sensory perception contributes to social cognition impairments in ASD. Thus, the present study was aimed to elucidate how the audiovisual abilities were functionally altered in individuals with ASD by using non-invasive neurophysiological methods such as visual evoked potentials (VEPs) and near-infrared spectroscopy (NIRS). In VEPs, we found that individuals with ASD have altered automatic visual processing for emotional faces within the lower level of the visual cortex. In NIRS, we demonstrated that a mother's voice modulated the activities of temporal voice and language areas in healthy children but not ASD children. Therefore, we conclude that these audiovisual impairments could be neural basis of the disrupted social cognition observed in individuals with ASD.

自闭症谱系障碍（ASD）的标志性特征是社会互动受损。非典型的感官感知可能导致ASD的社会认知障碍。因此，本研究的目的是通过使用非侵入性神经生理学方法（例如视觉诱发的电位（VEP）和近红外光谱（NIR）（NIRS），通过使用非侵入性神经生理学方法来阐明ASD个体的视听能力如何改变了视听能力。在VEP中，我们发现患有ASD的个体在视觉皮层较低层内改变了自动视觉处理的情感面孔。在NIR中，我们证明了母亲的声音调节健康儿童的暂时性语音和语言领域的活动，而不是ASD儿童。因此，我们得出的结论是，这些视听障碍可能是ASD患者观察到的破坏社会认知的神经基础。

项目成果

Real-time evaluation system for accurate VEP recording and analysis

实时评估系统，用于准确的 VEP 记录和分析

• DOI: 10.1109/iccme.2012.6275686
• 发表时间: 2012
• 期刊: 2012 IEEE/ICME International Conference on Complex Medical Engineering
• 作者: Goto K;Sugi T;Matsuda Y;Goto S;Fukuda H;Goto Y;Yamasaki T;et al.
• 通讯作者: et al.

Characteristic analysis of visual evoked potentials and posterior dominant rhythm by use of EEG model

脑电模型视觉诱发电位和后主导节律特征分析

• DOI: 10.1109/iccas.2013.6703899
• 发表时间: 2013
• 期刊: International Conference on Control, Automation and Systems
• 作者: Goto K;Sugi T;Matsuda Y;Goto S;Fukuda H;Goto Y;Yamasaki T;et al.
• 通讯作者: et al.

Motion perception in autism spectrum disorder. In : Columbus AM, Ed. Advances in Psychology Research, Volume 82, New York

自闭症谱系障碍的运动感知。

• 发表时间: 2011
• 作者: Yamasaki T;Fujita T;Kamio Y;Tobimatsu S.
• 通讯作者: Tobimatsu S.

急性中毒症状が明らかでなく初期診断が困難であった間欠型一酸化炭素中毒の1例:急性発症性認知症の鑑別診断

急性中毒症状不明确、初步诊断困难的间歇性一氧化碳中毒一例：急性发作性痴呆的鉴别诊断

• 发表时间: 2012
• 期刊: 認知神経科学
• 作者: Goto K;Sugi T;Matsuda Y;Goto S;Fukuda H;Goto Y;Yamasaki T;et al.;山﨑貴男,他
• 通讯作者: 山﨑貴男,他

Rapid maturation of voice and linguistic processing systems in preschool children: A near-infrared spectroscopic study

学龄前儿童语音和语言处理系统的快速成熟：近红外光谱研究

• DOI: 10.1016/j.expneurol.2013.10.005
• 发表时间: 2013
• 期刊: Experimental Neurology
• 影响因子: 5.3
• 作者: Yamasaki;T.;Ogata;K.;Maekawa;T.;Ijichi;I.;Katagiri;M.;Mitsudo;T.;Kamio;Y.;Tobimatsu;S.
• 通讯作者: S.