Noninvasive evaluation of intracranial vessel wall lesions using high-resolution three-dimensional magnetic resonance vessel wall imaging

高分辨率三维磁共振血管壁成像无创评估颅内血管壁病变

• 批准号: 23591789
• 负责人: SASAKI Makoto
• 金额: $ 3.33万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591789/
• 关键词: MRI; 血管壁; 頭蓋内動脈; 動脈硬化; 動脈解離

We attempted to evaluate intracranial arterial wall lesions by using a T1-weighted three-dimensional vessel wall imaging (3D-VWI) technique. In patients with acute non-cardioembolic stroke in middle cerebral artery (MCA) territory, wall thickening of the MCA, which is suggestive of atherosclerotic plaques, was observed in all the patients. In addition, signal intensity of the plaque was significantly increased in the ipsilateral MCA and in the patients with atherothrombolic infarction. In patients with acute vertebrobasilar artery dissection, characteristic findings such as luminal stenosis, aneurysmal dilatation, and intramural hematoma were readily depicted on 3D-VWI when compared with conventional imaging techniques. The 3D-VWI technique can directly visualize intracranial arterial wall lesions in patients with ischemic stroke and dissection, and can be helpful to diagnose these disorders particularly in the acute period.

我们尝试使用 T1 加权三维血管壁成像 (3D-VWI) 技术来评估颅内动脉壁病变。在大脑中动脉 (MCA) 区域患有急性非心源性卒中的患者中，所有患者均观察到 MCA 壁增厚，这提示存在动脉粥样硬化斑块。此外，同侧 MCA 和动脉粥样硬化性梗塞患者的斑块信号强度显着增加。与传统成像技术相比，在患有急性椎基底动脉夹层的患者中，3D-VWI 很容易描绘出管腔狭窄、动脉瘤性扩张和壁内血肿等特征性表现。 3D-VWI技术可以直接显示缺血性中风和夹层患者的颅内动脉壁病变，有助于诊断这些疾病，特别是在急性期。

项目成果

Evaluating Middle Cerebral Artery Atherosclerotic Lesions in Acute Ischemic Stroke Using Magnetic Resonance T1-weighted 3-Dimensional Vessel Wall Imaging

• DOI: 10.1016/j.jstrokecerebrovasdis.2013.06.025
• 发表时间: 2014-04-01
• 期刊: JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
• 影响因子: 2.5
• 作者: Natori, Tatsunori;Sasaki, Makoto;Terayama, Yasuo
• 通讯作者: Terayama, Yasuo