Modulation of endoplasmic reticulum stress by modification of cholesterol contents in liver.

通过改变肝脏中的胆固醇含量来调节内质网应激。

• 批准号: 23591333
• 负责人: TSUKAMOTO Kazuhisa
• 金额: $ 3.41万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591333/
• 关键词: 小胞体ストレス; コレステロール; 肝臓; 糖代謝

There are three pathways which increase hepatic cholesterol contents. In this study, these 3 pathways have been up-regulated by adenoviral gene transfer. All these pathways increased the hepatic cholesterol contents; however, none did induce the ER stress. On the other hand, all three pathways caused the amelioration of blood glucose level; however, the molecular mechanisms underlying the amelioration of blood glucose were different among the pathways. Both the pharmacological induction and inhibition of ER stress evoked the accumulation of hepatic triglycerides. These results suggest that the association between hepatic ER stress and glucose and lipid metabolism would not be straightforward.

有三种增加肝胆固醇含量的途径。 在这项研究中，这三种途径已被腺病毒基因转移上调。 所有这些途径增加了肝胆固醇含量。但是，没有人会诱导ER应力。 另一方面，这三个途径引起了血糖水平的改善。然而，在这些途径之间，血糖改善的基础机制不同。 药理学诱导和ER应激的抑制都引起了肝甘油三酸酯的积累。 这些结果表明，肝ER应激与葡萄糖和脂质代谢之间的关联并不是直接的。

项目成果

Hepatic NPC1L1 over- expression attenuated gluconeo- genesis and VLDL-triglycerides secretion via the suppression of hepatic FoxO1 pathway

肝脏 NPC1L1 过表达通过抑制肝脏 FoxO1 途径减弱糖异生和 VLDL 甘油三酯分泌

• 发表时间: 2012
• 作者: Makoto Kurano;Masumi Hara;Kazuhisa Tsukamoto
• 通讯作者: Kazuhisa Tsukamoto

Postprandial hyperlipidemia. Importance of Factors affecting hepatic VLDL secretion

餐后高脂血症。

• 发表时间: 2014
• 作者: Tsutsumi C;Imagawa A;Ikegami H;Makino H;Kobayashi T;Hanafusa T;Kurano M. Iso-O N. Hara M. Ishizaka N. Moriya K. Koike K. Tsukamoto K.;Ikegami H;Naru Babaya et al.;Kazuhisa Tsukamoto
• 通讯作者: Kazuhisa Tsukamoto

LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL.

• DOI: 10.1186/1476-511x-10-134
• 发表时间: 2011-08-05
• 期刊: Lipids in health and disease
• 影响因子: 4.5
• 作者: Kurano M;Iso-O N;Hara M;Ishizaka N;Moriya K;Koike K;Tsukamoto K
• 通讯作者: Tsukamoto K

Hepatic NPC1L1 overexpression ameliorated glucose metabolism in diabetic mice via suppression of FoxO1 mediated gluconeogenesis

肝脏 NPC1L1 过表达通过抑制 FoxO1 介导的糖异生改善糖尿病小鼠的葡萄糖代谢

• 发表时间: 2013
• 作者: Makoto Kurano;Masumi Hara;Koichi Tsuneyama;Atsuko Takai;Kentaro Kikuchi;Nobukazu Ishizaka;Teruhiko Matsushima;Kazuhisa Tsukamoto
• 通讯作者: Kazuhisa Tsukamoto

Postprandial Hyperlipidemia

餐后高脂血症

• 发表时间: 2014
• 作者: Tsutsumi C;Imagawa A;Ikegami H;Makino H;Kobayashi T;Hanafusa T;Kurano M. Iso-O N. Hara M. Ishizaka N. Moriya K. Koike K. Tsukamoto K.;Ikegami H;Naru Babaya et al.;Kazuhisa Tsukamoto;Tsutsumi C et al.;Ikegami H;Kazuhisa Tsukamoto
• 通讯作者: Kazuhisa Tsukamoto