Influence of chronic kidney disease on carotid atherosclerosis, stroke features, and outcomes of thrombolysis for acute stroke

慢性肾脏病对颈动脉粥样硬化、卒中特征和急性卒中溶栓结果的影响

• 批准号: 23591288
• 负责人: TOYODA Kazunori
• 金额: $ 3.08万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591288/
• 关键词: 脳血管障害; 慢性腎臓病; 頸動脈硬化; 脳腎連関; 脳出血; 脳梗塞; rt-PA静注療法

To determine associations between chronic kidney disease (CKD) and cerebrovascular diseases, in the other words cerebro-renal interaction, the following studies were performed. (1) In the Suita Study, an epidemiological study involving Japanese urban residents, the association of CKD with carotid atherosclerosis was modest, but CKD was independently associated with carotid atherosclerosis in hypertensive subjects. (2) In acute intracerebral hemorrhage patients, excessive reduction of systolic blood pressure was associated with acute worsening renal function. Worsening renal function was related to unfavorable clinical outcome. (3) In the multicenter study, renal dysfunction was independently associated with unfavorable outcomes in rt-PA-treated ischemic stroke patients and those in intracerebral hemorrhage patients. (4) An English review on cerebro-renal interaction was completed partly based on the current study results.

为了确定慢性肾脏病（CKD）与脑血管疾病之间的关联，即脑肾相互作用，进行了以下研究。 (1) 在吹田研究（一项涉及日本城市居民的流行病学研究）中，CKD 与颈动脉粥样硬化的相关性不大，但 CKD 与高血压受试者的颈动脉粥样硬化独立相关。 (2)在急性脑出血患者中，收缩压过度降低与肾功能急性恶化有关。肾功能恶化与不良的临床结果有关。 (3) 在多中心研究中，肾功能障碍与 rt-PA 治疗的缺血性卒中患者和脑出血患者的不良结局独立相关。 (4)根据目前的研究结果部分完成了脑肾相互作用的英文综述。

项目成果

超急性期脳梗塞治療:4.5時間時代のrt-PA静注療法

超急性脑梗死治疗：4.5小时时代的rt-PA静脉治疗

• 发表时间: 2013
• 作者: Hiroki Mizukami;Kazunori Takahashi;Wataru Inaba;Kohsuke Kamata;Kentarou Tsuboi;Soroku Yagihashi;藤田征弘;豊田一則
• 通讯作者: 豊田一則

脳卒中医・神経内科医の救急への関わり

中风医生和神经科医生参与紧急护理

• 发表时间: 2013
• 作者: Takahashi K;Yamada T;Tsukita S;Kaneko K;Shirai Y;Munakata Y;Ishigaki Y;Imai J;Uno K;Hasegawa Y;Sawada S;Oka Y;Katagiri H.;豊田一則
• 通讯作者: 豊田一則

JRC蘇生ガイドライン2010

2010 年 JRC 复苏指南

• 发表时间: 2011
• 作者: Nishimura S;Ngasaki M;Manabe I;Eto K;Nagai R;豊田一則(作成委員)
• 通讯作者: 豊田一則(作成委員)

Epidemiology and registry studies of stroke in Japan.

• DOI: 10.5853/jos.2013.15.1.21
• 发表时间: 2013-01
• 期刊: Journal of stroke
• 影响因子: 8.2
• 作者: Toyoda K

Intracerebral hemorrhage during oral antithrombotic therapy

口服抗栓治疗期间发生脑出血

• 发表时间: 2012
• 作者: Mitsueda-Ono T;Ikeda A;Inouchi M;Takaya S;Matsumoto R;Hanakawa T;Sawamoto N;Mikuni N;Fukuyama H;Takahashi R;Toyoda K
• 通讯作者: Toyoda K