Crosstalk of glia and neuron: Broad-band EEG and neuroimaging analysis for epileptic foci

神经胶质细胞和神经元的串扰：癫痫病灶的宽带脑电图和神经影像分析

• 批准号: 23591275
• 负责人: IKEDA akio
• 金额: $ 3.41万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591275/
• 关键词: 発作時DC電位; 高周波数律動; てんかん焦点; グリア細胞; 神経細胞; 広域周波数帯域脳波; 広域周波数脳波解析; てんかん外科; 神経膠腫; 高周波律動（HFO); 難治てんかん; グリオーシス; 広域周波数脳波活動; 発作時DC電位; 高周波数律動; てんかん焦点; グリア細胞; 神経細胞; 広域周波数帯域脳波; 広域周波数脳波解析; てんかん外科; 神経膠腫; 高周波律動（HFO); 難治てんかん; グリオーシス; 広域周波数脳波活動

Recently it has been suggested that glia could be actively involved in epileptogenicity in addition to pathological firing of neurons (Iked et al, 1997, 1999). It has been thought that ictal DC shifts could reflect sustained depolarization of neurons augmented by glial passive depolarization, but receently active and earlier role of glia for ictal DC shifts has been suggested. High frequency oscillation (HFO) could reflect neural firing activity. We clarified the features of ictal DC shifts and HFO and implicated them closely in generating epileptic seizures. Additionally, it was also suggested that DC shifts and HFO had distinct generating mechanisms. We aimed to apply the results for delineating epileptic foci in each patients and to provide our findings to neuroscience.

最近有人提出，除了神经元的病理触发外，神经胶质可能会积极参与癫痫发作（Iked等，1997，1999）。据认为，发炎性直流变化可以反映神经胶质被动去极化增强神经元的持续去极化，但已提出了神经胶质对ICTAL DC转移的活性和早期作用。高频振荡（HFO）可以反映神经发射活动。我们阐明了ICTAL DC SHIFT和HFO的特征，并紧密牵涉到产生癫痫发作的特征。此外，还建议直流变化和HFO具有不同的生成机制。我们旨在将结果应用于每个患者中描述癫痫灶，并将我们的发现提供给神经科学。