Pathophysiological effect of circulating monocyte subsets on thrombus formation following by coronary plaque rupture

循环单核细胞亚群对冠状动脉斑块破裂后血栓形成的病理生理学影响

• 批准号: 23591058
• 负责人: IMANISHI Toshio
• 金额: $ 3.16万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591058/
• 关键词: 血栓; 単球サブセット; 急性冠症候群; 冠血管イメージング; 冠動脈内血栓; 血栓; 単球サブセット; 急性冠症候群; 冠血管イメージング; 冠動脈内血栓

Although monocytes appear to be actively involved in the onset of acute coronary syndrome (ACS), they are heterogenous in human peripheral blood. We thereofore investigated the relationship between the expression of P-selectin glycoprotein ligand-1 (PSGL-1) on monocyte subsets and thrombus formation using frequency-domain optical coherence tomography (FD-OCT) in patients with ACS. We enrolled patients with acute myocardial infarction (AMI, n=25), unstable angina pectoris (UAP, n=20), or stable angina pectoris (n=35), and control subjects (n=20). The expression of PSGL-1 on circulating peripheral CD14++CD16+ monocytes was significantly elevated in patients with AMI compared with the other 3 groups. The expression levels of PSGL-1 on CD14++CD16+ monocytes were significantly higher in patients with plaque rupture or intracoronary thrombus assessed by FD-OCT. We concluded that up-regulation of PSGL-1 on CD14++CD16+ monocytes may be a crucial role in plaque rupture and thrombus formation.

尽管单核细胞似乎积极参与急性冠状动脉综合征（ACS）的发作，但它们在人类外周血中是异质的。我们福雷研究了使用频率域光学相干性层析成像（FD-OCT）在单核细胞亚群上P-选择蛋白糖蛋白配体1（PSGL-1）的表达之间的关系。我们招募了急性心肌梗塞（AMI，n = 25），不稳定的心绞痛（UAP，n = 20）或稳定的心绞痛（n = 35）和对照组（n = 20）的患者。与其他3组相比，AMI患者的PSGL-1在循环外周CD14 ++ CD16+单核细胞中的表达显着升高。通过FD-OCT评估的斑块破裂或尸体内血栓的患者，CD14 ++ CD16+单核细胞上PSGL-1的表达水平明显更高。我们得出的结论是，在CD14 ++ CD16+单核细胞上的PSGL-1上调可能在牙菌斑破裂和血栓形成中至关重要。