Relationship between lifestyle-related diseases in childhood and the risk for atherosclerotic coronary heart disease in adulthood (studies on lipoprotein abnormality, adipocytokine, vascular endothelial function and related genes)

儿童期生活方式相关疾病与成年后动脉粥样硬化性冠心病风险的关系（脂蛋白异常、脂肪细胞因子、血管内皮功能及相关基因研究）

基本信息

批准号：
17390303
负责人：
OHTA Takao
金额：
$ 10.04万
依托单位：
University of the Ryukyus
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Many studies have shown that life-style related disorders are risk factors for atherosclerotic coronary heart diseases (ACHD). The pathological arterial sclerosis lesion is present in children, and it is very likely that the development of atherosclerotic lesion is accelerated with the presence of life-style related diseases even in children. Thus, in the present study, we studied the relationship between body weight and serum concentrations of adipocytokines in school children and neonates. In schoolchildren, all adipocytokines evaluated (adiponectin, leptin, Il-6, IL-18, IL-1β) were positively correlated with body weight except for adiponectin. Adiponectin was inversely correlated with body weight These findings were similar to those in adults, thereby suggesting that overweight was a risk factor for ACHD even in children. Differed from school children, serum concentrations of adiponectin were positively associated with body weight in preterm and term infants. To date, some roles of … More adipocytokines such as IL-6 and TNF-α have been highlighted in the inverse correlation between adiponectin and body weight in adults. It has been shown that IL-6 and TNF-α reduce the secretion of adiponectin from adipocytes. Some kinds of inflammation in adipose tissue might contribute to the inverse correlation between adiponectin and body weight. If inflammation or levels of pro-inflammatory adipocytokines were not elevated in adipose tissue, adiponectin secretion from adipocytes might not be reduced. Since the increase in the body weight of the fetus during late pregnancy is a physiological development, it is reasonable to consider that an increase in adipose tissue at this stage might not accompany the inflammation in adipose tissue. Furthermore, the ratio of high-molecular adiponectin (active adiponectin) to total adiponectin was significantly smaller in preterm infant that that in term infant. As adiponectin was secreted from adipocytes, our findings suggest that development of adipose tissue in preterm infants might be different from term infant. This may explain the relation of low birth weight to future development of ACHD. Less

许多研究表明，生活方式相关疾病是动脉粥样硬化性冠心病（ACHD）的危险因素。儿童存在病理性动脉硬化病变，并且很可能随着生活的存在而加速动脉粥样硬化病变的发展。因此，在本研究中，我们研究了学龄儿童和新生儿的体重与脂肪细胞因子血清浓度之间的关系。评估结果（脂联素、瘦素、IL-6、IL-18、IL-1β）与体重呈正相关，但脂联素与体重呈负相关。这些结果与成人相似，因此表明超重是一个危险因素。即使在儿童中，脂联素的血清浓度与早产儿和足月儿的体重呈正相关。 IL-6 和 TNF-α 等脂肪细胞因子在成人脂联素与体重之间的负相关性中得到了突出显示，IL-6 和 TNF-α 可以减少脂肪细胞中脂联素的分泌。如果脂肪组织中的炎症或促炎脂肪细胞因子的水平没有升高，则脂肪组织可能导致脂联素与体重之间的负相关。脂肪细胞分泌的脂联素可能不会减少。由于妊娠后期胎儿体重的增加是一种生理性组织发育，因此有理由认为，这一阶段的脂肪增加可能不会伴随脂肪组织的炎症。此外，早产儿的高分子脂联素（活性脂联素）占总脂联素的比例明显小于足月儿分泌的脂联素。脂肪细胞，我们的研究结果表明，早产儿脂肪组织的发育可能与足月儿不同，这可能解释了低出生体重与 ACHD 未来发展的关系。