Elucidation of condylar cartilage resorption mechanism in TMJ-osteoarthritis and search of a new regulatory factor.

阐明颞下颌关节骨关节炎髁软骨吸收机制并寻找新的调节因子。

• 批准号: 23390474
• 负责人: TANNE KAZUO
• 金额: $ 5.99万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-11-18 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390474/
• 关键词: 歯学; 再生医学; 細胞・組織; シグナル伝達; 生理活性; 変形性顎関節症; 軟骨; SZP

It is suggested that hyaronan(HA) affects superficial zone protein (SZP) expression through CD44 receptor. Interaction between SZP and HA in articular cartilage may be be critical for proper lubricating function in the surface of articular cartilage.In addition, High magnitude cyclic tensile strain (CTS) upregulates pro-inflammatory cytokines and matrix metalloproteinases (MMPs) in chondrocytes, while selective cyclooxygenase (COX)-2 inhibition has been shown to be beneficial to cytokine-induced cartilage damage. Celecoxib exerts protective effects on mandibular condylar chondrocytes under CTS stimulation by diminishing degradation and restoring synthesis of ECM. This result is in preparation to be submitted in the Journal of Cell tissue Res and Osteoarthritis Cartilage.

建议通过CD44受体影响透明质酸（HA）影响表面蛋白（SZP）的表达。 Interaction between SZP and HA in articular cartilage may be be critical for proper lubricating function in the surface of articular cartilage.In addition, High magnitude cyclic tensile strain (CTS) upregulates pro-inflammatory cytokines and matrix metalloproteinases (MMPs) in chondrocytes, while selective cyclooxygenase (COX)-2 inhibition has been shown to be beneficial细胞因子诱导的软骨损伤。 Celecoxib通过减少ECM的降解和恢复合成，对CTS刺激下的下颌do孔软骨细胞发挥保护作用。该结果是准备在细胞组织RES和骨关节炎软骨的杂志上提交的结果。

项目成果

Current status of TMD

TMD现状

• 发表时间: 2012
• 作者: Arifah Chieko Ardin;仲野道代;藤田一世;仲野和彦;Tanne K
• 通讯作者: Tanne K

Current status of temporomandibular joint disorders and the therapeutic system integrated with orthodontic approach

颞下颌关节疾病现状及正畸综合治疗体系

• 发表时间: 2011
• 作者: 鈴木理紗子;根本英二;島内英俊;山田哲司， 野呂林太郎， 本田一文;Tanne Kazuo
• 通讯作者: Tanne Kazuo

Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage

• DOI: 10.1007/s00441-011-1156-z
• 发表时间: 2011-05-01
• 期刊: CELL AND TISSUE RESEARCH
• 影响因子: 3.6
• 作者: Tanimoto, Kotaro;Kamiya, Takashi;Tanne, Kazuo
• 通讯作者: Tanne, Kazuo

顎関節症に対応した矯正歯科治療

颞下颌关节疾病的正畸治疗

• 发表时间: 2011
• 作者: 金谷聡介;根本英二;島内英俊;谷本幸太郎
• 通讯作者: 谷本幸太郎

Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress

• DOI: 10.1016/j.joca.2014.03.011
• 发表时间: 2014-06-01
• 期刊: OSTEOARTHRITIS AND CARTILAGE
• 影响因子: 7
• 作者: Su, S. -C.;Tanimoto, K.;Tanne, K.
• 通讯作者: Tanne, K.