DEVELOPMENT OF COMPUTER-AIDED PRESCRIPTION SYSTEM FOR PERSONALIZED PHARMACOTHERAPY BASED ON THE PHAEMACOKINETICS AND PHARMACODYNAMICS

基于药代动力学和药效学的个体化药物治疗计算机辅助处方系统的开发

基本信息

批准号：
16390043
负责人：
SAWADA Yasufumi
金额：
$ 7.87万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

The aim of this study was to develop the computer-aided system that assists dosage regiment optimization, prescription checking, proper use of drugs and distribution of drug information based on the pharmacokinetics and pharmacodynamics. We developed algorithms for personalized pharmacotherapy with regard to 1) dosage adjustment of quinolone antibiotics and angiotensin converting enzyme inhibitors in patients with renal dysfunction, 2) quantitative estimation of time-dependent effects of St.John's wort on the drug metabolism and excretion, 3) receptor occupancy-estimation of antipsychotics-induced adverse reactions, 4) dose regime recommendations to avoid drug interaction between new-quinolones and metal cations, 5) estimation of dosing interval dependency of the interaction between itraconazole and triazolam, 6) assessment of the effects of α1-adorenoceptor antagonists in benign prostatic hyperplasia based on the receptor occupancy theory, 7) avoiding piloerection associated with antidepressants, and 8) optimization of the dosage regimen of TS-1 (a combination preparation of tegafur, gimeracil and oteracil potassium). We also developed prototype systems for some of the above algorithms on a personal computer. For example, with regard to the above 1), we developed a computer-aided system that helps to optimize the dosage and dosing time in patients with arbitrary grade of renal function by adjusting the patient's plasma concentration profile to that of subjects with normal renal function.Moreover, we inquired, by pharmacists' questionnaire, the needs for the computer-aided systems for dosage optimization after patients' poor compliance or alteration of the dosage form, and developed the prototypes. We also inquired into the standardization of drug information with regard to the dosage formulation to develop a computer-aided prescription checking system. (260 words)

本研究的目的是开发计算机辅助系统，根据药代动力学和药效学，协助剂量方案优化、处方检查、药物正确使用和药物信息分发。我们开发了关于 1) 剂量的个性化药物治疗算法。肾功能不全患者喹诺酮类抗生素和血管紧张素转换酶抑制剂的调整，2）定量评估圣约翰草对药物代谢和排泄的时间依赖性影响，3）受体抗精神病药引起的不良反应的占用率估计，4）避免新喹诺酮类药物与金属阳离子之间药物相互作用的剂量方案建议，5）估计伊曲康唑和三唑仑之间相互作用的给药间隔依赖性，6）评估α1的效果-基于受体占据理论的良性前列腺增生症中的肾上腺素受体拮抗剂，7)避免与抗抑郁药相关的立毛，以及8) TS-1（替加氟、吉美嘧啶和奥替拉西钾的组合制剂）的方案剂量的优化我们还在个人计算机上开发了上述一些算法的原型系统。，我们开发了一种计算机辅助系统，通过将患者的血浆浓度曲线调整为肾功能正常受试者的血药浓度曲线，有助于优化肾功能任意级别患者的剂量和给药时间。此外，我们询问，通过药剂师的调查问卷，患者依从性差或剂型改变后对计算机辅助系统进行剂量优化的需求，并开发了原型，我们还调查了与剂量配方有关的药物信息的标准化，以开发一个剂量配方。计算机辅助处方检查系统（260字）