High density simulation for transcriptional dynamics

转录动力学的高密度模拟

• 批准号: 22700309
• 负责人: OHTA Yoshihiro
• 金额: $ 2.25万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700309/
• 关键词: 転写; シミュレーション; RNAPII; RNA; セルオートマトン; バイオインフォマティクス

RNA polymerase II(RNAPII) is the responsible motor protein for transcription. Here we studied the formulation and results of a cellular automaton model of the RNAPII dynamics of gene transcription that takes account the effect of the velocity change according to the gene position, such as occurs in introns and exons. It was found that the RNAPII molecules move as a free-flow state, though regions of reduced velocity do exist such as exons, as far as the time interval between nearest RNAPII molecules is larger than the time required for an RNAPII passing the exclusion length in the velocity reduction region.

RNA 聚合酶 II (RNAPII) 是转录的负责马达蛋白。在这里，我们研究了基因转录 RNAPII 动力学的细胞自动机模型的公式和结果，该模型考虑了根据基因位置（例如在内含子和外显子中发生的）速度变化的影响。研究发现，RNAPII 分子以自由流动状态移动，尽管确实存在速度降低的区域（例如外显子），只要最近的 RNAPII 分子之间的时间间隔大于 RNAPII 通过排除长度所需的时间。速度减小区域。