The mechanism of hyperalgesia in the spinal dorsal horn revealed by imaging of neuronal activity

神经元活动成像揭示脊髓背角痛觉过敏机制

• 批准号: 22600005
• 负责人: IKEDA Hiroshi
• 金额: $ 3万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22600005/
• 关键词: 痛覚; イメージング; 脊髄後角; グリア細胞; 神経可塑性; 痛覚過敏; 膜電位イメージング; カルシウムイメージング; アストロサイト; 電位イメージング

There are distinct glia-related mechanisms for the central sensitization in different persistent pain, that is microglia-related and astrocyte-related mechanisms in neuropathic and inflammatory pain, respectively.

不同持续性疼痛的中枢敏化存在不同的胶质细胞相关机制，即神经病理性疼痛和炎性疼痛中分别为小胶质细胞相关和星形胶质细胞相关机制。

项目成果

Astrocyte involves in the long-term facilitation of neuronal excitation in the anterior cingulate cortex of mice with inflammatory pain.

星形胶质细胞参与长期促进炎症性疼痛小鼠前扣带皮层神经元兴奋。

• 作者: H. Ikeda;K. Mochizuki;K. Murase
• 通讯作者: K. Murase

Contribution of emotional and descending pain inhibitory system in the brain to analgesia effect of lemon odor

大脑情绪和下行疼痛抑制系统对柠檬气味镇痛作用的贡献

• 作者: 竹内 祥太;池田 弘;村瀬 一之
• 通讯作者: 村瀬 一之

Agumentation of neuronal excitability by glial cells in the rat spinal dorsal horn under persistent pain state revealed by optical imaging with voltage-sensitive dye

电压敏感染料光学成像显示持续疼痛状态下大鼠脊髓背角神经胶质细胞对神经元兴奋性的增强

• 作者: 村山 美郷;池田 弘;村瀬 一之
• 通讯作者: 村瀬 一之

Long-term potentiation of neuronal excitation in the central nucleus of the rat amygdala revealed by imaging with a voltage-sensitive dye

• DOI: 10.1016/j.brainres.2010.06.039
• 发表时间: 2010-08-19
• 期刊: BRAIN RESEARCH
• 影响因子: 2.9
• 作者: Kiritoshi, Takaki;Ikeda, Hiroshi;Murase, Kazuyuki
• 通讯作者: Murase, Kazuyuki

Contribution of the descending pain inhibitory system to the analgesic effect by smelling the aroma oil.

下行疼痛抑制系统通过闻芳香油来发挥镇痛作用。

• 作者: 高須 俊太郎;池田 弘;村瀬 一之;竹内 翔汰
• 通讯作者: 竹内 翔汰