Thermochemotherapy with controlled drug delivery using a novel magnetic anti-cancer drug

使用新型磁性抗癌药物进行控制药物输送的热化疗

• 批准号: 22592243
• 负责人: MITSUDO Kenji
• 金额: $ 2.5万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592243/
• 关键词: 口腔癌; 新規磁性抗癌剤; 家兎 VX2 癌; 温熱療法; Drug Delivery System; 家兎VX2癌; 新規磁性抗がん剤; 温熱化学療法; 化学療法; 家兎VX2舌癌; 家兎VX2癌細胞; Drug Delivery System (DDS); ハイパーサーミア

A new magnetic anticancer drug (=New drug) was developed giving an anti-tumor effect by fragmenting DNA and controlling cell proliferation, depending on its density. The New drug is characterized by being a magnetic substance, which accumulates locally through impression of a magnetic field using a permanent magnet. As a result, it could be used as a drug delivery system. In addition, it was clarified that the New drug generates heat because of the high frequency magnetic field impression; thus, it is expected to be effective for intra-tissue hyperthermia.We performed a comparative MTT assay assessing the antitumor effects of the New drug against cisplatin(CDDP), an anticancer drug mainly used for oral cancer. We also created a tongue tumor model into which the VX2 cell line was transplanted, and performed an animal experiment using the New drug. This result suggests that EI236 become a new drug for the treatment of oral cancer.

一种新的磁性抗癌药物（=新药）被开发出来，通过断裂 DNA 并根据其密度控制细胞增殖来发挥抗肿瘤作用。该新药的特点是它是一种磁性物质，通过使用永磁体施加磁场而在局部积累。因此，它可以用作药物输送系统。此外，还澄清了新药因高频磁场作用而发热；因此，预计它对组织内热疗有效。我们进行了比较MTT试验，评估新药对顺铂（CDDP）（一种主要用于口腔癌的抗癌药物）的抗肿瘤作用。我们还建立了移植VX2细胞系的舌肿瘤模型，并使用新药进行了动物实验。这一结果表明EI236成为治疗口腔癌的新药。

项目成果

Thermochemoradiotherapy using superselective intra-arterial infusion via a superficial temporal artery and an occipital artery for N3 cervical lymphnode metastases of oral cancer

经颞浅动脉和枕动脉超选择性动脉内灌注热放化疗治疗口腔癌 N3 颈淋巴结转移

• 发表时间: 2011
• 作者: Mitsudo K.;他
• 通讯作者: 他

進行口腔癌に対する浅側頭動脈よりの超選択的動注化学放射線療法-腫瘍栄養動脈による頸部転移リンパ節への病理組織効果-

颞浅动脉超选择性动脉内灌注放化疗治疗晚期口腔癌 - 肿瘤供血动脉对颈部转移淋巴结的组织病理学影响 -

• 发表时间: 2010
• 作者: 光藤健司;他
• 通讯作者: 他

Thermochemoradiotherapy for Oral Cancer with N2,3 Cervical Lymph Node Metastases using Retrograde Superselective Intra-arterial Infusion.

使用逆行超选择性动脉内输注热化疗治疗伴有 N2,3 颈部淋巴结转移的口腔癌。

• 发表时间: 2012
• 期刊: Thermal Med
• 作者: Yusuke Zushi;Mako Narisawa-Saito,Kazuma Noguchi;Yuki Yoshimatsu;Takashi Yugawa;Nagayasu Egawa;Masatoshi Fujita;Masahiro Urade;Tohru Kiyono;宮崎晃亘,小林淳一,山本崇,道振義貴,佐々木敬則,仲盛健治,廣橋良彦,鳥越俊彦,佐藤昇志,平塚博義;Mitsudo K
• 通讯作者: Mitsudo K

Thermochemoradiation therapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases.

• DOI: 10.1016/j.ijrobp.2012.02.057
• 发表时间: 2012-08
• 期刊: International journal of radiation oncology, biology, physics
• 作者: K. Mitsudo;T. Koizumi;M. Iida;T. Iwai;S. Oguri;N. Yamamoto;Y. Itoh;M. Kioi;M. Hirota;I. Tohnai

Thermochemoradiotherapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases.

通过颞浅动脉和枕动脉进行超选择性动脉内输注的热放化疗治疗伴有 N3 颈淋巴结转移的口腔癌。

• 发表时间: 2012
• 期刊: Inl J Radiat Oncol Biol Phys
• 作者: Mitsudo K;Koizumi T;Iida M;Iwai T;Oguri S;Yamamoto N;Itoh Y;Kioi M;Hirota M;Tohnai I.
• 通讯作者: Tohnai I.