Suppression of anoikis by galectin-1 in human oral squamous cell carcinoma cells

半乳糖凝集素-1对人口腔鳞状细胞癌细胞失巢凋亡的抑制作用

• 批准号: 22592076
• 负责人: KAMO Masaharu
• 金额: $ 2.41万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592076/
• 关键词: 口腔生化学; 癌; アノイキス; 口腔扁平上皮癌細胞; 上皮間葉転換; 細胞外マトリックス; TGF-β; ガレクチン-1; EMT; 口腔扁平上皮癌; 細胞遊走; プロテオミクス; 歯学; シグナル伝達; タンパク質; プロテオーム

It is necessary to evade anoikis so that tumor cells derived from epithelium cause metastasis. In human oral squamous cell carcinoma cells (hOSCC) HSC-3, galectin-1 is a factor suppressing anoikis. It was shown that a cellular survival signal was increased, and then anoikis was suppressed by galectin-1 binding to an epidermal growth factor acceptor. On the other hand, it is capable by obtaining the property of mesenchymal cell by epithelial-mesenchymal transition (EMT) for evasion of anoikis. The correlation was found in the hOSCC cells between reactivity to transforming growth factor-β (TGF-β) and degree of the EMT. The results suggest that the EMT and integrin pathway-mediated migration of TGF-β1-stimulated HSC-4 hOSCC cells is positively controlled by transcription factor Slug.

有必要逃避Anoikis，以便衍生自上皮的肿瘤细胞会导致转移。在人口服鳞状细胞癌细胞（HOSCC）HSC-3中，lectectin-1是抑制Anoikis的因素。结果表明，增加了细胞存活信号，然后通过与表皮生长因子受体结合抑制Anoikis。另一方面，它可以通过上皮 - 间质转变（EMT）获得间充质细胞的特性来获得厌氧菌的进化。在HOSCC细胞中发现了对转化​​生长因子-β（TGF-β）的反应性与EMT程度之间的相关性。结果表明，TGF-β1刺激的HSC-4 HOSCC细胞的EMT和整合素途径介导的迁移由转录因子SLUG积极控制。

项目成果

EGFが歯周靭帯由来血管内皮前駆細胞様細胞の増殖と筋線維芽細胞分化に与える影響について

EGF对牙周膜源性血管内皮祖细胞增殖和肌成纤维细胞分化的影响

• 发表时间: 2012
• 作者: 宮崎隆;堀田康弘;木村仁迪
• 通讯作者: 木村仁迪

Cellular Biosignal Sciences｜細胞情報科学分野

细胞生物信号科学｜细胞信息科学

Dental pulp cells derived from permanent teeth express higher levels of R-cadher in than do deciduous teeth : Implications of the correlation between R-cadherin expression and restriction of multipotency in mesenchymal stem cells

恒牙衍生的牙髓细胞比乳牙表达更高水平的 R-cadher ：R-cadherin 表达与间充质干细胞多能性限制之间相关性的意义

• DOI: 10.1016/j.archoralbio.2011.07.013
• 发表时间: 2011
• 期刊: Archives of Oral Biology
• 影响因子: 3
• 作者: Yoshihiro Uesawa;Masami Kawase;Mariko Ishihara;Hiroshi Sakagami,;Takahashi N
• 通讯作者: Takahashi N

間葉系幹細胞由来サイトカイン様ペプチドSCRG1は破骨細胞分化を抑制する

间充质干细胞衍生的细胞因子样肽 SCRG1 抑制破骨细胞分化

• 作者: 西原一秀;松山孝司;松井竜太郎;野添悦郎;中村典史;齋藤大嗣;横田潤;西原一秀;青松恵美子
• 通讯作者: 青松恵美子

Effect of fibroblast growth factor-2 on periodontal ligament cells derived from human deciduous teeth in vitro

• DOI: 10.3892/etm_00000052
• 发表时间: 2010-03-01
• 期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE
• 影响因子: 2.7
• 作者: Hasegawa, Tomokazu;Chosa, Naoyuki;Tanaka, Mitsuro
• 通讯作者: Tanaka, Mitsuro