The study of the improvement mechanism with the pulmonary protective therapy of the acute pulmonary injury: Work of breathing analysis and microcirculation for an index

肺保护治疗对急性肺损伤改善机制的研究——以呼吸分析和微循环为指标

• 批准号: 22592022
• 负责人: NISHIYAMA Keiko
• 金额: $ 2.75万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592022/
• 关键词: 集中治療医学; 人工呼吸器; 呼吸仕事量; 呼吸不全; PEEP; PC-PSVモード; 急性肺傷害; 集中治療医学; 人工呼吸器; 呼吸仕事量; 呼吸不全; PEEP; PC-PSVモード; 急性肺傷害

In the fundamental research, microcirculation dynamics at sepsis was studied using the rabbit ear chamber (REC). An arteriolar vascular diameter, a blood flow rate and motions of venular leukocyte were directly recorded in REC and analyzed at the early stage of the sepsis. In the clinical research, arterial blood gas, chest X-ray, CT, a physical examination, and clinical course were analyzed by changing parameters of the ventilation modes for respirator wearing patients. We evaluated the work of breathing and the synchronous characteristics to spontaneous respiration, andfound a more physiological ventilation mode with higher therapeutic gain than conventional modes.

在基本研究中，使用兔耳室（REC）研究了败血症的微循环动力学。直接记录在REC中的小动脉血管直径，血液流量和静脉白细胞的运动，并在脓毒症的早期进行分析。在临床研究中，通过改变呼吸器佩戴患者的通风模式的参数来分析动脉血液，胸部X射线，CT，体格检查和临床过程。我们评估了自发呼吸的呼吸和同步特征的工作，并与传统模式相比，具有更高治疗性增长的生理通风模式。