Analysis of the distribution of cohesin in human oocytes to figure out the mechanism of age-related increase of chromosomal nondisjunction.

分析人类卵母细胞中粘连蛋白的分布，以找出与年龄相关的染色体不分离增加的机制。

• 批准号: 22790334
• 负责人: TSUTSUMI Makiko
• 金额: $ 2.25万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790334/
• 关键词: 減数分裂; 卵母細胞; 高齢出産; 不妊症; 習慣流産; コヒーシン; 染色体不分離

In humans, age-related increase of aneuploidy in oocytes is known as one of the causes of the birth of offspring with Down's syndrome or miscarriage. It has been suggested that the decrease of the molecules, cohesins, involving chromosome segregation in meiosis contributes aneuploidy. In this study, I asked whether the amount of cohesins has actually decreased in aged human oocytes, and showed that the cohesins of oocytes could be detected in aged women. However, the comparison between ages has not yet proceeded because of the unavailability of enough samples at this time.

在人类中，卵母细胞中与年龄相关的非整倍性的增加被称为唐氏综合症或流产后代出生的原因之一。有人提出，分子的降低，粘着蛋白，涉及减数分裂中染色体分离的分离促成非整倍性。在这项研究中，我询问人类卵母细胞的粘着素量是否实际下降，并表明在老年女性中可以检测到卵母细胞的粘着蛋白。但是，由于目前没有足够的样本，年龄之间的比较尚未进行。

项目成果

Mutation in the SYCP3 gene identified in a woman with recurrent pregnancy loss affects pairing of the homologous chromosomes during the prophase of meiosis

在反复妊娠流产的女性中发现的 SYCP3 基因突变影响减数分裂前期同源染色体的配对

• 发表时间: 2011
• 作者: Saitsu H;et al.;Nishiyama K;堤真紀子
• 通讯作者: 堤真紀子

SYCP3変異による習慣流産の発症メカニズムの解析

SYCP3突变导致习惯性流产的发病机制分析

• 发表时间: 2011
• 作者: Saitsu H;others;Nishiyama K;others.;堤真紀子
• 通讯作者: 堤真紀子

Mutation in the SYCP3 gene identified in women with recurrent pregnancy loss affects pairing of the homologous chromosomes during the prophase of meiosis I

在反复妊娠流产的女性中发现的 SYCP3 基因突变影响减数分裂 I 前期同源染色体的配对

• 发表时间: 2011
• 作者: Saitsu H;Tohyama J;Kumada T;Egawa K;Hamada K;Okada I;Mizuguchi T;Osaka H;Miyata R;Furukawa T;Haginoya K;Hoshino H;Goto T;Hachiya Y;Yamagata T;Saitoh S;Nagai T;Nishiyama K;Nishimura A;Miyake N;Komada M;Hayashi K;Hirai S;Ogata K;Kato;堤真紀子
• 通讯作者: 堤真紀子

卵母細胞の体外培養系を用いた習慣流産原因遺伝子の解析

使用体外卵母细胞培养系统分析导致习惯性流产的基因

• 发表时间: 2010
• 作者: Fu YJ;Nishihira Y;Kuroda S;Toyoshima Y;Ishihara T;Shinozaki M;Miyashita A;Piao YS;Tan CF;Tani T;Koike R;Iwanaga K;Tsujihata M;Onodera O;Kuwano R;Nishizawa M;Kakita A;Ikeuchi T;Takahashi H;堤真紀子
• 通讯作者: 堤真紀子

Mutation in the SYCP3 gene identified in a woman with recurrent pregnancy loss affect the synaptonemal complex conformation at meiotic prophase I

在反复妊娠流产的女性中发现的 SYCP3 基因突变影响减数分裂前期 I 的联会复合体构象

• 发表时间: 2011
• 作者: Tsutsumi M;Kogo H;Inagaki H;Ohye T;Kurahashi H
• 通讯作者: Kurahashi H