Expression of Ovary-Specific Acidic Protein in Steroidogenic Tissues : A Possible Role in Steroidogenesis

卵巢特异性酸性蛋白在类固醇生成组织中的表达：在类固醇生成中的可能作用

• 批准号: 22791550
• 负责人: MATSUMOTO Tadashi
• 金额: $ 2.58万
• 依托单位: Keio University (2011)Tokai University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791550/
• 关键词: ステロイド産生; ミトコンドリア; OSAP; アポトーシス; Ovary Specific Acid Protein; 副腎皮質細胞; 胎児副腎; ステロイド産生; ミトコンドリア; OSAP; アポトーシス; Ovary Specific Acid Protein; 副腎皮質細胞; 胎児副腎

Our results indicate that the mitochondrial protein OSAP is abundantly expressed in steroidogenic tissues with a few exceptions. The results also suggest that OSAP is involved in steroidogenesis. However, our findings point to a permissive role for OSAP in steroidogenesis rather than a regulatory role because OSAP expression was not stimulated by a cAMP analog. Thus, we speculate that this protein could be involved in insuring optimal steroidogenesis through maintaining mitochondrial abundance and/or function. Further studies are warranted to substantiate this postulated role for OSAP in steroidogenic cells.

我们的结果表明，线粒体蛋白OSAP在类固醇组织中大量表达，但有一些例外。结果还表明OSAP参与类固醇生成。但是，我们的发现表明OSAP在类固醇生成中的允许作用而不是调节作用，因为CAMP类似物没有刺激OSAP表达。因此，我们推测该蛋白可以通过维持线粒体丰度和/或功能来确保最佳类固醇生成。有必要进行进一步的研究来证实OSAP在类固醇生成细胞中的作用。