Analysis of effects of general anesthetics on TRP receptors aiming at elucidation of action mechanisms of general anesthetics

分析全身麻醉药对TRP受体的影响，阐明全身麻醉药的作用机制

• 批准号: 22791461
• 负责人: TERADA Tadanori
• 金额: $ 2.5万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791461/
• 关键词: 麻酔学; TRP受容体; TRPM8受容体; 抗うつ薬; デュロキセチン; 鎮痛機序メカニズム; 全身麻酔薬; TRPA1受容体; 全身麻酔薬の作用機序; イソフルラン; セボフルラン; アフリカツメガエル卵母細胞発現系; TRPV1受容体; カプサイシン

We demonstrated that general anesthetics enhanced TRP receptors function, suggesting that effects of general anesthetics on TRP receptors are not related to anesthetic effects. On the other hands, we found that antidepressant, duloxetine for neuropathic pain inhibits the function of TRPM8 receptor, which is one of TRP receptor subtypes. It has been proposed that TRPM8 receptor is related to cold allodynia that is one of neuropathic pain symptom, indicating that inhibition of TRPM8 function may be one of action mechanisms of duloxetine. Development of new analgesics for neuropathic pain can be expected by further investigations about this effect.

我们证明了一般麻醉剂增强了TRP受体的功能，这表明大麻醉对TRP受体的影响与麻醉效应无关。另一方面，我们发现用于神经性疼痛的抗抑郁剂杜洛西汀抑制了TRP受体亚型之一的TRPM8受体的功能。已经提出，TRPM8受体与神经性疼痛症状之一有关，表明抑制TRPM8功能可能是Duloxetine的动作机制之一。通过对此作用的进一步研究，可以期望开发新的镇痛药来治疗神经性疼痛。