The Role of Epac2 as a new target of sulfonylurea drugs
Epac2作为磺酰脲类药物新靶点的作用
基本信息
- 批准号:22790860
- 负责人:
- 金额:$ 2.58万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Young Scientists (B)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Incretin/cAMP signaling and sulfonylurea synergistically augment insulin secretion from pancreatic β-cell. This interacting effect involves the enhancement of Epac2/Rap1 signaling and depends on the action of sulfonylureas on Epac2.
肠静脉/cAMP信号传导和磺酰尿素从胰腺β细胞协同增强胰岛素分泌。这种相互作用的效果涉及EPAC2/RAP1信号的增强,并取决于磺酰鲁氏对Epac2的作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Rim2a determines docking and priming states in insulin granule exocytosis
Rim2a 决定胰岛素颗粒胞吐作用中的对接和启动状态
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:29
- 作者:Yasuda T;Shibasaki T;Minami K;Takahashi H;Mizoguchi A;Uriu Y;Mori Y;Miyazaki J-i;Miki T;Seino S
- 通讯作者:Seino S
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TAKAHASHI Harumi的其他基金
The role of Epac2A/Rap1 signaling in the protection of pancreatic beta-cell
Epac2A/Rap1信号在保护胰腺β细胞中的作用
- 批准号:16K0974916K09749
- 财政年份:2016
- 资助金额:$ 2.58万$ 2.58万
- 项目类别:Grant-in-Aid for Scientific Research (C)Grant-in-Aid for Scientific Research (C)
Establishment of pharmacogenetic-based dosing algorithm of warfarin for Asian, Caucasian and African American patients
针对亚洲、白人和非裔美国患者建立基于药物遗传学的华法林剂量算法
- 批准号:2359065223590652
- 财政年份:2011
- 资助金额:$ 2.58万$ 2.58万
- 项目类别:Grant-in-Aid for Scientific Research (C)Grant-in-Aid for Scientific Research (C)
Individualization of anticoagulation therapy of warfarin based on pharmacogenetic information
基于药物遗传学信息的华法林抗凝治疗个体化
- 批准号:2059054820590548
- 财政年份:2008
- 资助金额:$ 2.58万$ 2.58万
- 项目类别:Grant-in-Aid for Scientific Research (C)Grant-in-Aid for Scientific Research (C)
Studies on production of resistant variant of Japanese pear 'Osa Nijisseiki' to Alternaria alternata Japanese pear pathotype by means of somatic mutation.
通过体细胞突变生产日本梨Osa Nijisseiki对Alternaria alternata日本梨病型的抗性变种的研究。
- 批准号:1366003913660039
- 财政年份:2001
- 资助金额:$ 2.58万$ 2.58万
- 项目类别:Grant-in-Aid for Scientific Research (C)Grant-in-Aid for Scientific Research (C)
Establishment of The Effective and Safe Anticoagulation Therapy for Japanese Patients
为日本患者建立有效且安全的抗凝治疗
- 批准号:1267070312670703
- 财政年份:2000
- 资助金额:$ 2.58万$ 2.58万
- 项目类别:Grant-in-Aid for Scientific Research (C)Grant-in-Aid for Scientific Research (C)
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