Development of the next generation radiation therapy based on molecular imaging

基于分子成像的下一代放射治疗的发展

• 批准号: 22591392
• 负责人: NISHIMURA Yasumasa
• 金额: $ 2.83万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591392/
• 关键词: 放射線治療; 生物学; 腫瘍; 低酸素; PET; 放射線療法; 低酸素領域; 18F-ミソニダゾール; 再酸素化現象; 分割照射; 強度変調放射線治療; ^<18>F-ミソニダゾール; 効果予測

To visualize intratumoral hypoxic areas and their reoxygenation before and during fractionated radiation therapy (RT), 18F-fluoromisonidazole positron emission tomography and computed tomography (F-MISO PET/CT) were performed. Ten patients, consisting of four head and neck cancers, four gastrointestinal cancers, one lung cancer, and one uterine cancer, were included. F-MISO PET/CT was performed twice before RT and during fractionated RT of approximately 20 Gy/10 fractions for eight of the 10 patients. F-MISO maximum standardized uptake values (SUVmax) of normal muscles and tumors were measured. The tumor-to-muscle (T/M) ratios of F-MISO SUVmax were also calculated. Mean SUVmax ± standard deviation (SD) of normal muscles was 1.25 ± 0.17, and SUVmax above the mean + 2 SD (≧1.60 SUV) was regarded as a hypoxic area. Nine of the 10 tumors had an F-MISO SUVmax of equal to or more than 1.60. All eight tumors examined twice showed a decrease in SUVmax, T/M ratio, or percentage of hypoxic volume (F-MISO ≧1.60) at approximately 20 Gy, indicating reoxygenation. In conclusion, accumulation of F-MISO of ≧1.60 SUV was regarded as an intratumoral hypoxic area in our F-MISO PET/CT system. Most human tumors (90%) in this small series had hypoxic areas before RT, although hypoxic volume was minimal (0.0-0.3%) for four of the 10 tumors. In addition, reoxygenation was observed in most tumors at two weeks of the fractionated RT.

为了可视化分离放射治疗（RT）之前和期间的肿瘤内低氧区域及其重氧，进行了18F-氟甲唑胺极性发射断层扫描和计算机断层扫描（F-MISO PET/CT）。包括十名患者，包括四个头颈癌，四种胃肠道癌，1例肺癌和一个子宫癌。在RT之前进行了两次F-MISO PET/CT，在10例患者中，有8例在分离RT的RT分数约为20 Gy/10个部分。测量了正常肌肉和肿瘤的F-MISO最大标准化摄取值（SUVMAX）。还计算了F-Miso Suvmax的肿瘤与肌肉（T/M）比。正常肌肉的平均SUVMAX±标准偏差（SD）为1.25±0.17，超过平均值 + 2 SD（≧1.60SUV）的SUVMAX被视为低氧区域。 10个肿瘤中有9个具有等于或大于1.60的F-MISO SUVMAX。两次检查的所有八个肿瘤均显示suvmax，T/M比或低氧体积的百分比（F-Miso≧1.60）约为20 Gy，表明重氧。总之，F-Miso≧1.60SUV的积累被认为是我们的F-Miso PET/CT系统中的肿瘤内低氧区域。在此小型系列中，大多数人类肿瘤（90％）在RT之前具有低氧区域，尽管在10个肿瘤中有四个低氧量最小（0.0-0.3％）。另外，在分离的RT的两周内，大多数肿瘤都观察到了氧化。

项目成果

A two-step adaptive Intensity modulated radiation therapy (IMRT) scheme for head and neck cancer

头颈癌的两步自适应调强放射治疗 (IMRT) 方案

• 发表时间: 2012
• 作者: 藤田真由美;今留香織;遠藤悟史;荘司好美;山田滋;今井高志;Nishimura Y
• 通讯作者: Nishimura Y

PET/CT による放射線治療計画

使用 PET/CT 制定放射治疗计划

• 发表时间: 2011
• 作者: 立花和泉;西村恭昌;柴田徹;中松清志;金森修一;小池竜太;西川龍之;石川一樹;田村昌也;細野 眞
• 通讯作者: 細野 眞

Clinical practice and outcome of radiotherapy for esophageal cancer between 1999 and 2003: the Japanese Radiation Oncology Study Group (JROSG) Survey

• DOI: 10.1007/s10147-011-0254-y
• 发表时间: 2012-02-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Nishimura, Yasumasa;Koike, Ryuta;Tamamoto, Tetsuro
• 通讯作者: Tamamoto, Tetsuro

A two-step method of IMRT for head and neck cancer

头颈癌 IMRT 的两步法

• 发表时间: 2013
• 作者: Takashi Imai;Atsuko Ishikawa;Tomo Suga;Yoshimi Shoji;Nishimura Y
• 通讯作者: Nishimura Y

A prospective clinical trial on tumor hypoxia imaging with 18F-misonidazole (F-MISO) positron emission tomography (PET)

18F-米索硝唑 (F-MISO) 正电子发射断层扫描 (PET) 肿瘤缺氧成像的前瞻性临床试验

• 发表时间: 2011
• 作者: Tachibana I;Nishimura Y;Shibata T;Kanamori S;Nakamatsu K;Tamura M;Koike R;Nishikawa T;Ishikawa K. Hosono M
• 通讯作者: Ishikawa K. Hosono M