MR-cellular density imaging for evaluation of early response to chemotherapy.

MR 细胞密度成像用于评估化疗的早期反应。

• 批准号: 22591363
• 负责人: MATSUSHIMA Shigeru
• 金额: $ 2.75万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591363/
• 关键词: 癌; 早期治療効果判定; 分子画像; 細胞密度画像; 機能画像; 磁気共鳴; 磁化移動効果; 肝細胞特異性造影剤

The aim of this study was to evaluate an early prediction of response to chemotherapy by MR-cellular density imaging. We developed " contrast enhance ratio in hepatocellular (CERH) imaging, Uptake CERH imaging " and " Equivalent cross-relaxation rate (ECR) imaging " as MR-cellular density imaging. Uptake CERH images can visualize heterogeneous and partial uptake liver function. ECR images can be applied early prediction of response to chemotherapy according to decrease of cellular density.

本研究的目的是评估通过 MR 细胞密度成像对化疗反应的早期预测。我们开发了“肝细胞对比增强比（CERH）成像、摄取CERH成像”和“等效交叉弛豫率（ECR）成像”作为MR细胞密度成像。摄取 CERH 图像可以显示异质和部分摄取的肝功能。 ECR 图像可根据细胞密度的降低来早期预测化疗反应。

项目成果

Evaluated the correlation of uptake contrast enhanced ratio in hepato-biliary phase imaging to existing liver function tests.

评估肝胆相成像中摄取对比增强比与现有肝功能测试的相关性。

• 发表时间: 2013
• 作者: S. Matsushima;Y. Sato;H. Yamaura;M. Kato;D. Inoue;Y. Kinosada;S. Era;K. Takahashi;Y. Inaba
• 通讯作者: Y. Inaba

Evaluation of parotid gland function using equivalent cross-relaxation rate imaging applied magnetization transfer effect.

使用等效交叉弛豫率成像应用磁化传递效应评估腮腺功能。

• 发表时间: 2012
• 期刊: Journal of Radiation Research
• 影响因子: 2
• 作者: H. Shimizu;S. Matsushima;Y. Kinosada;H. Miyamura;T. Kubota;H. Osaki;M. Nakayama;M. Yoshimoto;T. Kodaira.
• 通讯作者: T. Kodaira.

Comparative intermolecular cross-relaxation studies of human hemoglobin in red blood cells and bovine serum albumin in solution.

红细胞中人血红蛋白和溶液中牛血清白蛋白的分子间交叉弛豫比较研究。

• 发表时间: 2011
• 期刊: NMR Biomed.
• 作者: S. Era;M. Sogami;N. Uyesaka;M. Murakami;S. Matsushima and Y. Kinosada.
• 通讯作者: S. Matsushima and Y. Kinosada.

Comparative 1H NMR studied of saturation transfer in copolymer gels and mouse lenses

共聚物凝胶和小鼠晶状体中饱和转移的比较 1H NMR 研究

• 发表时间: 2010
• 作者: S.Era;M. Sogami;K. Nakamura;S. Matsushima;Y. Kinosada
• 通讯作者: Y. Kinosada

Preoperative evaluation of future remnant liver function by the contrast enhance ratio in hepatocellular image

术前通过肝细胞图像对比增强率评估未来的残余肝功能

• 发表时间: 2011
• 作者: S. Matsushima;Y. Sato;H. Yamaura;M. Kato;T. Kanamoto;Y. Kinosada;S. Era;H. Koyanagi;Y. Inaba
• 通讯作者: Y. Inaba